Primary Site >> Stomach Cancer
Gene >> SRC
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Ref: [Clinical trials of the subrenal capsule assay]. PMID: 3619457 |
Ref: [Proto-oncogene expression in human carcinomas of the stomach and in the gastric mucosa of rats exposed to N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis]. PMID: 2924705 |
Ref: pp60c-src protein kinase activity in human gastric carcinomas. PMID: 2110550 |
Ref: Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. PMID: 1655790 Ref: [Biochemical and molecular biological aspects of stomach cancer development in human and animal]. PMID: 1812623 Ref: [Synthesis and distribution of oncoproteins in tumor tissue]. PMID: 1839874 Ref: Effects of tyrosine kinase inhibitor, erbstatin, on cell growth and growth-factor/receptor gene expression in human gastric carcinoma cells. PMID: 1849125 |
Ref: Increased expression and phosphorylation of sh-ptp2 (syp) in human gastric carcinomas. PMID: 21597824 |
Ref: [Relationship between the express product of src gene (pp60c-src) and the initiation of gastric carcinoma]. PMID: 9208625 |
Ref: Up-regulated cytoplasmic expression, with reduced membranous distribution, of the src substrate p120(ctn) in gastric carcinoma. PMID: 10547572 |
Ref: pp60c-src activation in gastric carcinoma: a preliminary study. PMID: 10710104 |
Ref: Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell. PMID: 12458339 |
Ref: Src family kinases in tumor progression and metastasis. PMID: 12884910 |
Ref: TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity. PMID: 14720123 Ref: Functional analysis of the cag pathogenicity island in Helicobacter pylori isolates from patients with gastritis, peptic ulcer, and gastric cancer. PMID: 14742552 |
Ref: Crosstalk between Src and major vault protein in epidermal growth factor-dependent cell signalling. PMID: 16441665 Ref: Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation. PMID: 16816379 |
Ref: IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. PMID: 17304514 Ref: Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. PMID: 17363565 Ref: Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene. PMID: 17438024 Ref: The role of epithelial-mesenchymal transition in cancer pathology. PMID: 17558857 Ref: Cysteine-rich 61 (CCN1) enhances chemotactic migration, transendothelial cell migration, and intravasation by concomitantly up-regulating chemokine receptor 1 and 2. PMID: 18025257 Ref: Stimulation of extracellular signal-regulated kinases and proliferation in the human gastric cancer cells KATO-III by obestatin. PMID: 18365868 |
Ref: Secreted LOXL2 is a novel therapeutic target that promotes gastric cancer metastasis via the Src/FAK pathway. PMID: 19625348 |
Ref: Clinicopathologic features of gastric carcinoma with signet ring cell histology. PMID: 20033340 Ref: Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB. PMID: 20228839 Ref: Identification of c-Src as a potential therapeutic target for gastric cancer and of MET activation as a cause of resistance to c-Src inhibition. PMID: 20406949 Ref: Inhibition of Src impairs the growth of met-addicted gastric tumors. PMID: 20628031 |
Ref: ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion. PMID: 21076469 Ref: Overexpression of Cullin1 is associated with poor prognosis of patients with gastric cancer. PMID: 21190721 Ref: Oncogenic CagA promotes gastric cancer risk via activating ERK signaling pathways: a nested case-control study. PMID: 21698158 |
Ref: A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium. PMID: 21400081 Ref: PTP1B expression contributes to gastric cancer progression. PMID: 21442314 Ref: Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein-focal adhesion kinase (FAK) signaling pathways. PMID: 22039045 Ref: LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells. PMID: 22085492 Ref: Resistance to TRAIL is mediated by DARPP-32 in gastric cancer. PMID: 22589394 Ref: The CRKL gene encoding an adaptor protein is amplified, overexpressed, and a possible therapeutic target in gastric cancer. PMID: 22591714 Ref: Detection of kinase amplifications in gastric cancer archives using fluorescence in situ hybridization. PMID: 22691185 |
Ref: Irinotecan resistance is accompanied by upregulation of EGFR and Src signaling in human cancer models. PMID: 22973964 Ref: Antitumor activity of saracatinib (AZD0530), a c-Src/Abl kinase inhibitor, alone or in combination with chemotherapeutic agents in gastric cancer. PMID: 23144237 Ref: Synergistic antitumor effects of dasatinib and oxaliplatin in gastric cancer cells. PMID: 23712327 Ref: Posttranscriptional deregulation of Src due to aberrant miR34a and miR203 contributes to gastric cancer development. PMID: 23790975 Ref: Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells. PMID: 23799130 Ref: COX-2, TFF1, and Src define better prognosis in young patients with gastric cancer. PMID: 24037722 Ref: Epstein-Barr virus latent membrane protein 2 effects on epithelial acinus development reveal distinct requirements for the PY and YEEA motifs. PMID: 24109232 Ref: ER-alpha36-mediated gastric cancer cell proliferation via the c-Src pathway. PMID: 24137325 Ref: Mycophenolic acid inhibits migration and invasion of gastric cancer cells via multiple molecular pathways. PMID: 24260584 |
Ref: TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer. PMID: 24178904 Ref: Stage-stratified prognosis of signet ring cell histology in patients undergoing curative resection for gastric adenocarcinoma. PMID: 24394986 Ref: 17beta-estradiol inhibits mesenchymal stem cells-induced human AGS gastric cancer cell mobility via suppression of CCL5- Src/Cas/Paxillin signaling pathway. PMID: 24396281 Ref: Stromal fibroblasts mediate extracellular matrix remodeling and invasion of scirrhous gastric carcinoma cells. PMID: 24427313 Ref: The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer. PMID: 24492292 Ref: CEACAM6 promotes tumor migration, invasion, and metastasis in gastric cancer. PMID: 24492534 Ref: Saracatinib impairs the peritoneal dissemination of diffuse-type gastric carcinoma cells resistant to Met and fibroblast growth factor receptor inhibitors. PMID: 24612061 Ref: Src/caveolin-1-regulated EGFR activation antagonizes TRAIL-induced apoptosis in gastric cancer cells. PMID: 24840271 Ref: Role of c-Src activity in the regulation of gastric cancer cell migration. PMID: 24841138 Ref: Association of CXCR1 and 2 expressions with gastric cancer metastasis in ex vivo and tumor cell invasion in vitro. PMID: 25022956 Ref: Suberoylanilide hydroxamic acid enhances the antitumor activity of oxaliplatin by reversing the oxaliplatininduced Src activation in gastric cancer cells. PMID: 25199623 Ref: Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression. PMID: 25337202 |
Ref: Lysyl oxidase-like 4 (LOXL4) promotes proliferation and metastasis of gastric cancer via FAK/Src pathway. PMID: 25216702 Ref: The human epididymis protein 4 acts as a prognostic factor and promotes progression of gastric cancer. PMID: 25432133 Ref: Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer. PMID: 25544763 Ref: Frequent amplification of PTP1B is associated with poor survival of gastric cancer patients. PMID: 25590580 Ref: Cetuximab-induced insulin-like growth factor receptor I activation mediates cetuximab resistance in gastric cancer cells. PMID: 25625229 Ref: Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer. PMID: 25697906 Ref: Secreted protein acidic and rich in cysteine antagonizes bufalin-induced apoptosis in gastric cancer cells. PMID: 25936899 Ref: Emerging kinase inhibitors of the treatment of gastric cancer. PMID: 26021342 Ref: Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis. PMID: 26460485 Ref: miR-27b-3p suppresses cell proliferation through targeting receptor tyrosine kinase like orphan receptor 1 in gastric cancer. PMID: 26576539 Ref: Profile of nintedanib in the treatment of solid tumors: the evidence to date. PMID: 26677336 |
Ref: Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer. PMID: 25618371 Ref: Suppression of IL-8-Src signalling axis by 17beta-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion. PMID: 26945908 Ref: GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways. PMID: 27077843 Ref: Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro. PMID: 27122665 Ref: Early signet ring cell carcinoma of the stomach is related to favorable prognosis and low incidence of lymph node metastasis. PMID: 27562147 |
Ref: Prostaglandin E2 stimulates urokinase-type plasminogen activator receptor via EP2 receptor-dependent signaling pathways in human AGS gastric cancer cells. PMID: 27377703 Ref: Amplified 7q21-22 gene MCM7 and its intronic miR-25 suppress COL1A2 associated genes to sustain intestinal gastric cancer features. PMID: 28059478 Ref: RANKL/RANK pathway abrogates cetuximab sensitivity in gastric cancer cells via activation of EGFR and c-Src. PMID: 28123301 Ref: Resistance Mechanism against Trastuzumab in HER2-Positive Cancer Cells and Its Negation by Src Inhibition. PMID: 28223426 Ref: Introducing crucial protein panel of gastric adenocarcinoma disease. PMID: 28331560 Ref: Formation of the IGF1R/CAV1/SRC tri-complex antagonizes TRAIL-induced apoptosis in gastric cancer cells. PMID: 28403518 Ref: Tumor and serum gamma-glutamyl transpeptidase, new prognostic and molecular interpretation of an old biomarker in gastric cancer. PMID: 28404903 Ref: Combining multi-dimensional data to identify key genes and pathways in gastric cancer. PMID: 28603669 Ref: Ganetespib induces G2/M cell cycle arrest and apoptosis in gastric cancer cells through targeting of receptor tyrosine kinase signaling. PMID: 28713919 Ref: CXCL12/SDF-1alpha induces migration via SRC-mediated CXCR4-EGFR cross-talk in gastric cancer cells. PMID: 28781651 Ref: Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines. PMID: 28894280 |
Ref: Src promotes EGF-induced epithelial-to-mesenchymal transition and migration in gastric cancer cells by upregulating ZEB1 and ZEB2 through AKT. PMID: 29052277 Ref: By modulating alpha2beta1 integrin signalling, gastrin increases adhesion oF AGS-GR gastric cancer cells. PMID: 29253536 Ref: Src activation decouples cell division orientation from cell geometry in mammalian cells. PMID: 29653289 Ref: PTBP3 contributes to the metastasis of gastric cancer by mediating CAV1 alternative splicing. PMID: 29752441 Ref: Caveolin-1 contributes to anoikis resistance in human gastric cancer SGC-7901 cells via regulating Src-dependent EGFR-ITGB1 signaling. PMID: 30088837 |