Primary Site >> Liver Cancer

Gene >> SPTBN1

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Ref: Loss of cooperative function of transforming growth factor-beta signaling proteins, smad3 with embryonic liver fodrin, a beta-spectrin, in primary biliary cirrhosis.
PMID: 15566516
 Ref: Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests.
PMID: 17399697
Ref: Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation.
PMID: 17546056
Ref: Targeting ELF in therapy of liver cancer.
PMID: 19358343
 Ref: Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling.
PMID: 18263735
Ref: Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis.
PMID: 18704924
 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways.
PMID: 20549546
 Ref: Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
PMID: 22623320
 Ref: Transcriptional regulation of STAT3 by SPTBN1 and SMAD3 in HCC through cAMP-response element-binding proteins ATF3 and CREB2.
PMID: 25096061
 Ref: betaII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin.
PMID: 25307947
Ref: Bicluster and pathway enrichment analysis related to tumor progression of hepatocellular carcinoma.
PMID: 25912578
Ref: Analysis of DNA methylation in plasma for monitoring hepatocarcinogenesis.
PMID: 25923138
 Ref: Current complications and challenges in nonalcoholic steatohepatitis screening and diagnosis.
PMID: 26469309
Ref: Caspase-3/7-mediated Cleavage of beta2-spectrin is Required for Acetaminophen-induced Liver Damage.
PMID: 26884715
Ref: beta2-spectrin depletion impairs DNA damage repair.
PMID: 27248179
 Ref: IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition(+) metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient beta2-spectrin(+/-) mice.
PMID: 27863449
 Ref: Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-beta Pathway.
PMID: 28918914
Ref: Application of multiplex methylated-specific PCR with capillary electrophoresis to explore prognostic value of TSGs hypermethylation for hepatocellular carcinoma.
PMID: 29516551
Ref: Deep sequencing of human papillomavirus positive loco-regionally advanced oropharyngeal squamous cell carcinomas reveals novel mutational signature.
PMID: 29879932