Primary Site >> Colorectal Cancer
Gene >> SPP1
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Ref: Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells. PMID: 11149422 |
Ref: Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. PMID: 11929952 Ref: [Expression of osteopontin mRNA and its protein in colorectal cancer and liver metastatic tissues]. PMID: 12181091 Ref: [Expression and clinical significance of osteopontin in colorectal cancer and liver metastatic tissues]. PMID: 12487883 |
Ref: Osteopontin and colon cancer progression. PMID: 12650611 Ref: Distinct gene expression of osteopontin in patients with ulcerative colitis. PMID: 12842452 Ref: Osteopontin identified as colon cancer tumor progression marker. PMID: 14744111 |
Ref: Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. PMID: 14734468 Ref: Small integrin binding ligand N-linked glycoprotein gene family expression in different cancers. PMID: 15623631 Ref: Osteopontin regulates multiple functions contributing to human colon cancer development and progression. PMID: 15679049 |
Ref: Osteopontin silencing by small interfering RNA suppresses in vitro and in vivo CT26 murine colon adenocarcinoma metastasis. PMID: 15661802 Ref: Molecular staging for survival prediction of colorectal cancer patients. PMID: 15908663 Ref: Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells. PMID: 16024111 |
Ref: Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. PMID: 16670084 Ref: Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis. PMID: 16733264 Ref: Osteopontin inhibits macrophage nitric oxide synthesis to enhance tumor proliferation. PMID: 16904962 Ref: Molecular responses of rectal cancer to preoperative chemoradiation. PMID: 16905208 |
Ref: The role of osteopontin in tumor progression and metastasis in breast cancer. PMID: 17548669 Ref: Expression of osteopontin, a target gene of de-regulated Wnt signaling, predicts survival in colon cancer. PMID: 17565744 Ref: Sp1 regulates osteopontin expression in SW480 human colon adenocarcinoma cells. PMID: 17689681 Ref: Heterozygous disruption of the PTEN promotes intestinal neoplasia in APCmin/+ mouse: roles of osteopontin. PMID: 17693663 |
Ref: Expression profiling of angiogenic genes for the characterisation of colorectal carcinoma. PMID: 18656346 Ref: The database dbEST correctly predicts gene expression in colon cancer patients. PMID: 19075689 |
Ref: Potential biomarkers of colorectal adenoma-dysplasia-carcinoma progression: mRNA expression profiling and in situ protein detection on TMAs reveal 15 sequentially upregulated and 2 downregulated genes. PMID: 19096147 Ref: Expression of chemokines and chemokine receptors in human colon cancer. PMID: 19446722 Ref: Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers. PMID: 19549529 |
Ref: Clinical significance of the upregulated osteopontin mRNA expression in human colorectal cancer. PMID: 19763701 Ref: Osteopontin provides early proliferative drive and may be dependent upon aberrant c-myc signalling in murine intestinal tumours. PMID: 20053348 Ref: The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the "Fountain of Youth" to mediate healthful aging. PMID: 20227497 Ref: Elevated osteopontin expression and proliferative/apoptotic ratio in the colorectal adenoma-dysplasia-carcinoma sequence. PMID: 20349162 Ref: Increased osteopontin-positive macrophage expression in colorectal cancer stroma with synchronous liver metastasis. PMID: 20414778 Ref: Apc(MIN) modulation of vitamin D secosteroid growth control. PMID: 20488884 Ref: Regulation of osteopontin and related proteins in rat CC531 colorectal cancer cells. PMID: 20596651 Ref: A combination of serum markers for the early detection of colorectal cancer. PMID: 20798228 |
Ref: Up-regulation of the novel proinflammatory adipokines lipocalin-2, chitinase-3 like-1 and osteopontin as well as angiogenic-related factors in visceral adipose tissue of patients with colon cancer. PMID: 20961744 Ref: The potential of osteopontin as a therapeutic target for human colorectal cancer. PMID: 21318445 Ref: Expression of osteopontin coregulators in primary colorectal cancer and associated liver metastases. PMID: 21343932 Ref: Comparative profiling of primary colorectal carcinomas and liver metastases identifies LEF1 as a prognostic biomarker. PMID: 21383983 Ref: Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. PMID: 21459756 Ref: Butyrate suppresses mRNA increase of osteopontin and cyclooxygenase-2 in human colon tumor tissue. PMID: 21460853 Ref: Prognostic and predictive potential molecular biomarkers in colon cancer. PMID: 21696062 Ref: Influence of osteopontin expression on the metastatic growth of CC531 rat colorectal carcinoma cells in rat liver. PMID: 21852811 Ref: Osteopontin induced by macrophages contribute to metachronous liver metastases in colorectal cancer. PMID: 22196667 Ref: [Effects of osteopontin on gap junctional intercellular communication in colon cancer cell lines]. PMID: 22321891 |
Ref: Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. PMID: 22219064 Ref: Simultaneous multianalyte immunoassay measurement of five serum tumor markers in the detection of colorectal cancer. PMID: 22399621 Ref: Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer. PMID: 22444159 Ref: Prognostic value of tumor progression-related gene expression in colorectal cancer patients. PMID: 22614156 Ref: High levels of serum VEGF and TIMP-1 are correlated with colon cancer liver metastasis and intrahepatic recurrence after liver resection. PMID: 22807974 Ref: Osteopontin is overexpressed in colorectal carcinoma and is correlated with P53 by immunohistochemistry. PMID: 22969940 Ref: Microdensitometry of osteopontin as an immunohistochemical prognostic biomarker in colorectal carcinoma tissue microarrays: potential and limitations of the method in 'biomarker pathology'. PMID: 23072618 Ref: Osteopontin-enhanced hepatic metastasis of colorectal cancer cells. PMID: 23112867 Ref: Role of nuclear receptor NR4A2 in gastrointestinal inflammation and cancers. PMID: 23322982 |
Ref: Canonical Wnt signaling pathway plays an essential role in N-methyl-N-nitrosurea induced gastric tumorigenesis of mice. PMID: 23117827 Ref: Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. PMID: 23128103 Ref: Reciprocal interactions between tumor-associated macrophages and CD44-positive cancer cells via osteopontin/CD44 promote tumorigenicity in colorectal cancer. PMID: 23251004 Ref: Correlation of angiogenic biomarker signatures with clinical outcomes in metastatic colorectal cancer patients receiving capecitabine, oxaliplatin, and bevacizumab. PMID: 23634291 Ref: Control of the human osteopontin promoter by ERRalpha in colorectal cancer. PMID: 23680656 Ref: Development and characterization of a reliable mouse model of colorectal cancer metastasis to the liver. PMID: 23748471 Ref: The polymorphisms of osteopontin gene and plasma osteopontin protein levels with susceptibility to colorectal carcinoma. PMID: 23952692 Ref: Detection of serological biomarkers by proximity extension assay for detection of colorectal neoplasias in symptomatic individuals. PMID: 24107468 |
Ref: CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis. PMID: 24607406 Ref: Laparoscopic surgery for stage IV colorectal cancer. PMID: 24686351 Ref: Blood biomarkers are helpful in the prediction of response to chemoradiation in rectal cancer: a prospective, hypothesis driven study on patients with locally advanced rectal cancer. PMID: 24746569 Ref: Gene expression profiling of colorectal tumors and normal mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees. PMID: 24959000 Ref: Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells. PMID: 25132760 Ref: Circulating biomarkers in advanced colorectal cancer patients randomly assigned to three bevacizumab-based regimens. PMID: 25256831 |
Ref: Osteopontin expression in biopsies of calciphylaxis. PMID: 25847841 Ref: Post-operative plasma osteopontin predicts distant metastasis in human colorectal cancer. PMID: 25961724 Ref: Relationship between osteopontin and beta-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma. PMID: 25973035 Ref: Prognostic implications of adhesion molecule expression in colorectal cancer. PMID: 26097606 Ref: Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer. PMID: 26106421 Ref: The impact of osteopontin on prognosis and clinicopathology of colorectal cancer patients: a systematic meta-analysis. PMID: 26234583 Ref: Effect of antisense microRNA targeting survivin on rectal cancer HRC-9698 cells and its mechanism. PMID: 26261483 Ref: IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity. PMID: 26405589 |
Ref: Evaluation of a 5-Marker Blood Test for Colorectal Cancer Early Detection in a Colorectal Cancer Screening Setting. PMID: 26561557 Ref: A Rare Colon Cancer with Ossification: Pathogenetic Analysis of Bone Formation. PMID: 27466305 Ref: Increased Obesity-Associated Circulating Levels of the Extracellular Matrix Proteins Osteopontin, Chitinase-3 Like-1 and Tenascin C Are Associated with Colon Cancer. PMID: 27612200 Ref: Particularly interesting Cys-His-rich protein is highly expressed in human intracranial aneurysms and resists aneurysmal rupture. PMID: 28101173 |
Ref: Association of Osteopontin Gene Polymorphisms with Colorectal Cancer. PMID: 28095066 Ref: Osteopontin Promotes Cell Migration and Invasion, and Inhibits Apoptosis and Autophagy in Colorectal Cancer by activating the p38 MAPK Signaling Pathway. PMID: 28376477 Ref: Diagnostic Performance of a Novel Multiplex Immunoassay in Colorectal Cancer. PMID: 28476816 Ref: Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice. PMID: 28505114 Ref: SPP1, analyzed by bioinformatics methods, promotes the metastasis in colorectal cancer by activating EMT pathway. PMID: 28531945 Ref: The Allosteric Hemoglobin Effector ITPP Inhibits Metastatic Colon Cancer in Mice. PMID: 28742687 Ref: Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. PMID: 28745433 Ref: IL-32alpha-induced inflammation constitutes a link between obesity and colon cancer. PMID: 28811968 Ref: Osteopontin -- a promising biomarker for cancer therapy. PMID: 28819419 Ref: Colorectal carcinoma with osseous metaplasia. PMID: 29029440 |
Ref: Hypoxia induces differential expression patterns of osteopontin and CD44 in colorectal carcinoma. PMID: 29115557 Ref: Osteopontin-integrin engagement induces HIF-1alpha-TCF12-mediated endothelial-mesenchymal transition to exacerbate colorectal cancer. PMID: 29435158 Ref: HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer. PMID: 29504907 Ref: Upregulation of the adipokine genes ADIPOR1 and SPP1 is related to poor survival outcomes in colorectal cancer. PMID: 29761507 Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review). PMID: 29786110 Ref: In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. PMID: 29851214 Ref: Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. PMID: 29899427 Ref: Chemotherapy-generated cell debris stimulates colon carcinoma tumor growth via osteopontin. PMID: 29957058 Ref: Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma. PMID: 30175151 Ref: Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer. PMID: 30177776 Ref: Genetic and immunological biomarkers predict metastatic disease recurrence in stage III colon cancer. PMID: 30340556 Ref: Clinical Value of Combined Determination of Serum B7-H4 with Carcinoembryonic Antigen, Osteopontin, or Tissue Polypeptide-Specific Antigen for the Diagnosis of Colorectal Cancer. PMID: 30363700 |