Primary Site >> Biliary tract Cancer

Gene >> SPP1

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Ref: Decreased expression of osteopontin is related to tumor aggressiveness and clinical outcome of intrahepatic cholangiocarcinoma.
PMID: 15101999
Ref: Gene expression profiling identifies markers of ampullary adenocarcinoma.
PMID: 15136764
 Ref: Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: detection by oligonucleotide microarray and real-time PCR analysis.
PMID: 18442196
 Ref: A comprehensive analysis of immunohistochemical studies in intrahepatic cholangiocarcinoma using the survival tree model.
PMID: 19262069
 Ref: Osteopontin-positive infiltrating tumor-associated macrophages in bulky ampullary cancer predict survival.
PMID: 20495367
 Ref: Genome-wide expression patterns associated with oncogenesis and sarcomatous transdifferentation of cholangiocarcinoma.
PMID: 21333016
Ref: Prognosis of ampullary cancer based on immunohistochemical type and expression of osteopontin.
PMID: 21992455
 Ref: Molecular profiling of stroma identifies osteopontin as an independent predictor of poor prognosis in intrahepatic cholangiocarcinoma.
PMID: 23775819
 Ref: Osteopontin promoter polymorphisms at locus -443 are associated with metastasis and poor prognosis of human intrahepatic cholangiocarcinoma in Chinese population.
PMID: 25400775
 Ref: miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells.
PMID: 25769721
Ref: Osteopontin Promotes Hepatic Progenitor Cell Expansion and Tumorigenicity via Activation of beta-Catenin in Mice.
PMID: 26033745
 Ref: Clinicopathological Significance of Osteopontin in Cholangiocarcinoma Cases.
PMID: 26838210
Ref: Expression of Molecular Differentiation Markers Does Not Correlate with Histological Differentiation Grade in Intrahepatic Cholangiocarcinoma.
PMID: 27280413
 Ref: Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of beta-Catenin.
PMID: 29415992