Primary Site >> Stomach Cancer
Gene >> SP1
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Ref: Ectopic synthesis of pregnancy specific beta 1-glycoprotein (SP1) and placental specific tissue proteins (PP5, PP10, PP11, PP12) in nontrophoblastic malignant tumours. Possible markers in oncology. PMID: 6160287 |
Ref: [Immunohistochemical study of the expression of trophoblastic beta-1-globulin in the gastric epithelium of man in stomach cancer]. PMID: 1720986 |
Ref: The level of a transcription factor Sp1 is correlated with the expression of EGF receptor in human gastric carcinomas. PMID: 1282800 |
Ref: Overexpression of ZBP-89, a zinc finger DNA binding protein, in gastric cancer. PMID: 9144414 |
Ref: Sp1 and CREB mediate gastrin-dependent regulation of chromogranin A promoter activity in gastric carcinoma cells. PMID: 9852054 |
Ref: Genomic analysis of a murine cell-surface sialomucin, MGC-24/CD164. PMID: 10491205 |
Ref: Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoter. PMID: 11278696 |
Ref: Characterization of the human ABO gene promoter in erythroid cell lineage. PMID: 11856466 |
Ref: Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. PMID: 12509426 Ref: Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers. PMID: 12796395 Ref: Transcription factor Sp1 expression is a significant predictor of survival in human gastric cancer. PMID: 14695137 |
Ref: Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. PMID: 15109306 Ref: Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer. PMID: 15217947 Ref: A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. PMID: 16035620 |
Ref: Expression of endothelial nitric oxide synthase correlates with the angiogenic phenotype of and predicts poor prognosis in human gastric cancer. PMID: 15747170 Ref: Transcription factor Sp1 expression in gastric cancer and its relationship to long-term prognosis. PMID: 15818728 Ref: Altered expression of transcription factor Sp1 critically impacts the angiogenic phenotype of human gastric cancer. PMID: 16158248 Ref: [Transcription factor Sp1 expression in gastric cancer and its prognostic value]. PMID: 16438849 |
Ref: Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1. PMID: 16707418 Ref: Loss of Kruppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. PMID: 17085651 Ref: Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. PMID: 17187227 |
Ref: Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. PMID: 17273778 Ref: Comparative integromics on FZD7 orthologs: conserved binding sites for PU.1, SP1, CCAAT-box and TCF/LEF/SOX transcription factors within 5'-promoter region of mammalian FZD7 orthologs. PMID: 17273804 Ref: Clinical significance of CD99 down-regulation in gastric adenocarcinoma. PMID: 17473187 Ref: [Expression of transcription factor Sp1 in human gastric cancer tissue and its correlation with prognosis]. PMID: 17645844 |
Ref: Metastasis-associated protein S100A4 and p53 predict relapse in curatively resected stage III and IV (M0) gastric cancer. PMID: 18259945 Ref: Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. PMID: 18575762 Ref: Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. PMID: 19116449 |
Ref: Signaling components involved in Bcl-w-induced migration of gastric cancer cells. PMID: 19097687 Ref: [Expression of transcription factor SP1, vascular endothelial growth factor and CD34 in serosa-infiltrating gastric cancer and their relationship with biological behavior and prognosis]. PMID: 19296249 Ref: [EGFR-blockade by antibody Cetuximab inhibits the growth of human gastric cancer xenograft in nude mice and its possible mechanism]. PMID: 19538880 Ref: [Expression of hepatocyte growth factor, transcription factor SP1, vascular endothelial growth factor and CD34 in serosa-infiltrative gastric cancer and their relations with defluxion of gastric cancer cell and prognosis]. PMID: 19563076 Ref: Molecular characterization and significance for prognosis of free gastric cancer cells in the peritoneal cavity. PMID: 19621724 Ref: Interaction of Helicobacter pylori with genetic variants in the MDM2 promoter, is associated with gastric cancer susceptibility in Chinese patients. PMID: 19751436 |
Ref: Activation of RASSF2A by p300 induces late apoptosis through histone hyperacetylation. PMID: 20716062 |
Ref: Apoptosis induction by glycoprotein isolated from Laminaria japonica is associated with down-regulation of telomerase activity and prostaglandin E2 synthesis in AGS human gastric cancer cells. PMID: 21132266 Ref: Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer. PMID: 21170990 |
Ref: MicroRNA-335 acts as a metastasis suppressor in gastric cancer by targeting Bcl-w and specificity protein 1. PMID: 21822301 Ref: Small RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cells. PMID: 22363633 Ref: [Impacts of Bevacizumab on vascular endothelial growth factor and Sp1 expression in gastric cancer xenografts]. PMID: 22368029 Ref: Cloning and characterization of the porcine IL-10 promoter. PMID: 22469463 Ref: Induction of gastrin expression in gastrointestinal cells by hypoxia or cobalt is independent of hypoxia-inducible factor (HIF). PMID: 22593272 Ref: [Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1]. PMID: 23158992 |
Ref: EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells. PMID: 23121767 Ref: STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells. PMID: 23333463 Ref: Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14. PMID: 23394613 Ref: Low SP1 expression differentially affects intestinal-type compared with diffuse-type gastric adenocarcinoma. PMID: 23437057 Ref: miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. PMID: 23529765 Ref: miR-200b and miR-200c as prognostic factors and mediators of gastric cancer cell progression. PMID: 23995857 Ref: MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1. PMID: 24010737 |
Ref: Specificity protein 1 expression contributes to Bcl-w-induced aggressiveness in glioblastoma multiforme. PMID: 24552705 Ref: MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. PMID: 24613927 Ref: SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells. PMID: 24676680 Ref: Histone demethylase RBP2 induced by Helicobactor Pylori CagA participates in the malignant transformation of gastric epithelial cells. PMID: 25015565 |
Ref: SP1-induced upregulation of the long noncoding RNA TINCR regulates cell proliferation and apoptosis by affecting KLF2 mRNA stability in gastric cancer. PMID: 25728677 Ref: Identification of Critical Elements for Regulation of Inorganic Pyrophosphatase (PPA1) in MCF7 Breast Cancer Cells. PMID: 25923237 Ref: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell apoptosis by epigenetic silencing of KLF2. PMID: 25966845 Ref: Inactivation of BLU is associated with methylation of Sp1-binding site of BLU promoter in gastric cancer. PMID: 26043875 Ref: High co-expression of Sp1 and HER-2 is correlated with poor prognosis of gastric cancer patients. PMID: 26096373 Ref: DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells. PMID: 26695186 Ref: Long non-coding RNA ANRIL is upregulated in hepatocellular carcinoma and regulates cell proliferation by epigenetic silencing of KLF2. PMID: 27391317 |
Ref: SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation. PMID: 26511642 Ref: Epigenetic modification of TLR4 promotes activation of NF-kappaB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer. PMID: 26675260 Ref: Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers. PMID: 26880583 Ref: Overexpression of SULT2B1b Promotes Angiogenesis in Human Gastric Cancer. PMID: 26937945 Ref: miRNA-223 inhibits epithelial-mesenchymal transition in gastric carcinoma cells via Sp1. PMID: 27212195 Ref: hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor. PMID: 27325744 Ref: Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients. PMID: 27384994 Ref: miR-135a promotes gastric cancer progression and resistance to oxaliplatin. PMID: 27683111 Ref: Tumor-suppressing effects of microRNA-429 in human renal cell carcinoma via the downregulation of Sp1. PMID: 27698878 Ref: E2F-1 promotes DAPK2-induced anti-tumor immunity of gastric cancer cells by targeting miR-34a. PMID: 27704360 |
Ref: A polymorphism in the promoter region of PD-L1 serves as a binding-site for SP1 and is associated with PD-L1 overexpression and increased occurrence of gastric cancer. PMID: 27889799 Ref: Decreased Sp1 Expression Mediates Downregulation of SHIP2 in Gastric Cancer Cells. PMID: 28117748 Ref: Downregulation of Sp1 by Minnelide leads to decrease in HSP70 and decrease in tumor burden of gastric cancer. PMID: 28192510 Ref: Long noncoding AGAP2-AS1 is activated by SP1 and promotes cell proliferation and invasion in gastric cancer. PMID: 28209205 Ref: Long Noncoding RNA LINC00673 Is Activated by SP1 and Exerts Oncogenic Properties by Interacting with LSD1 and EZH2 in Gastric Cancer. PMID: 28214253 Ref: Novel Insights into Gastric Cancer: Methylation of R-spondins and Regulation of LGR5 by SP1. PMID: 28219935 Ref: Casticin inhibits the activity of transcription factor Sp1 and the methylation of RECK in MGC803 gastric cancer cells. PMID: 28352361 Ref: Long noncoding RNA UCA1 induced by SP1 promotes cell proliferation via recruiting EZH2 and activating AKT pathway in gastric cancer. PMID: 28569779 Ref: The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells. PMID: 28792527 Ref: CXXC4 activates apoptosis through up-regulating GDF15 in gastric cancer. PMID: 29262584 Ref: Glucose-derived AGEs enhance human gastric cancer metastasis through RAGE/ERK/Sp1/MMP2 cascade. PMID: 29262634 |
Ref: Serum microRNA panel excavated by machine learning as a potential biomarker for the detection of gastric cancer. PMID: 29286167 Ref: SP1 reduces autophagic flux through activating p62 in gastric cancer cells. PMID: 29328444 Ref: Inhibition of TNFalpha-interacting protein alpha (Tipalpha)-associated gastric carcinogenesis by BTG2(/TIS21) via downregulating cytoplasmic nucleolin expression. PMID: 29472702 Ref: Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149. PMID: 29593420 Ref: Histone deacetylase inhibitors induce the expression of tumor suppressor genes Per1 and Per2 in human gastric cancer cells. PMID: 30008892 Ref: miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer. PMID: 30013778 |