Primary Site >> Liver Cancer
Gene >> SOX2
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Ref: Comparative genomics on mammalian Fgf3-Fgf4 locus. PMID: 15942670 |
Ref: Long-term proliferation of human embryonic stem cell-derived neuroepithelial cells using defined adherent culture conditions. PMID: 16100006 |
Ref: The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. PMID: 18847459 |
Ref: The properties of tumor-initiating cells from a hepatocellular carcinoma patient's primary and recurrent tumor. PMID: 19897602 Ref: Expression of Oct4 in HCC and modulation to wnt/beta-catenin and TGF-beta signal pathways. PMID: 20549546 |
Ref: Induced pluripotent stem (iPS) cell research overview. PMID: 20887681 Ref: Role of Sox2 and Oct4 in predicting survival of hepatocellular carcinoma patients after hepatectomy. PMID: 21376027 Ref: Granulin-epithelin precursor is an oncofetal protein defining hepatic cancer stem cells. PMID: 22194816 |
Ref: Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145. PMID: 22378186 Ref: LIN28 expression and prognostic value in hepatocellular carcinoma patients who meet the Milan criteria and undergo hepatectomy. PMID: 22429493 Ref: Exploring stemness gene expression and vasculogenic mimicry capacity in well- and poorly-differentiated hepatocellular carcinoma cell lines. PMID: 22580004 |
Ref: p38alpha inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. PMID: 23271722 Ref: Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug. PMID: 23430442 Ref: The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. PMID: 23599755 Ref: Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. PMID: 23804702 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: Lin28B is an oncofetal circulating cancer stem cell-like marker associated with recurrence of hepatocellular carcinoma. PMID: 24244607 Ref: Cellular reprogramming and hepatocellular carcinoma development. PMID: 24379607 Ref: Tumor-initiating stem-like cells and drug resistance: carcinogenesis through Toll-like receptors, environmental factors, and virus. PMID: 25787983 |
Ref: The effect of hepatic progenitor cells on experimental hepatocellular carcinoma in the regenerating liver. PMID: 24188385 Ref: Twist2 promotes self-renewal of liver cancer stem-like cells by regulating CD24. PMID: 24193512 Ref: Influence of adriamycin on changes in Nanog, Oct-4, Sox2, ARID1 and Wnt5b expression in liver cancer stem cells. PMID: 24944491 Ref: Digital quantitation of HCC-associated stem cell markers and protein quality control factors using tissue arrays of human liver sections. PMID: 25218810 Ref: Prognostic value of SOX2 in digestive tumors: a meta-analysis. PMID: 25436295 |
Ref: Slug promotes hepatocellular cancer cell progression by increasing sox2 and nanog expression. PMID: 25339068 Ref: TAZ regulates cell proliferation and epithelial-mesenchymal transition of human hepatocellular carcinoma. PMID: 25495189 Ref: miR-126 inhibits cell proliferation and induces cell apoptosis of hepatocellular carcinoma cells partially by targeting Sox2. PMID: 25585946 Ref: psi-Bufarenogin, a novel anti-tumor compound, suppresses liver cancer growth by inhibiting receptor tyrosine kinase-mediated signaling. PMID: 25890498 Ref: PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. PMID: 26420065 Ref: Saturated fatty acid induces cancer stem cell-like properties in human hepatoma cells. PMID: 26518899 Ref: Knock out CD44 in reprogrammed liver cancer cell C3A increases CSCs stemness and promotes differentiation. PMID: 26540347 |
Ref: TALEN-induced disruption of Nanog expression results in reduced proliferation, invasiveness and migration, increased chemosensitivity and reversal of EMT in HepG2 cells. PMID: 26676719 Ref: Actin-like 6A predicts poor prognosis of hepatocellular carcinoma and promotes metastasis and epithelial-mesenchymal transition. PMID: 26698646 Ref: Peroxiredoxin II Is Essential for Maintaining Stemness by Redox Regulation in Liver Cancer Cells. PMID: 26866938 Ref: Hepatic cancer stem cell marker granulin-epithelin precursor and beta-catenin expression associate with recurrence in hepatocellular carcinoma. PMID: 26942873 Ref: Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells. PMID: 27050147 Ref: Bile acids promote diethylnitrosamine-induced hepatocellular carcinoma via increased inflammatory signaling. PMID: 27151938 Ref: CUL4B, NEDD4, and UGT1As involve in the TGF-beta signalling in hepatocellular carcinoma. PMID: 27236156 Ref: EpCAM-regulated intramembrane proteolysis induces a cancer stem cell-like gene signature in hepatitis B virus-infected hepatocytes. PMID: 27238755 Ref: SIRT1-mediated transcriptional regulation of SOX2 is important for self-renewal of liver cancer stem cells. PMID: 27312708 Ref: Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: From patients to patient-derived tumor xenograft models. PMID: 27329727 Ref: Arsenite inhibits the function of CD133(+) CD13(+) liver cancer stem cells by reducing PML and Oct4 protein expression. PMID: 27517564 Ref: Stemness-related transcriptional factors and homing gene expression profiles in hepatic differentiation and cancer. PMID: 27623812 Ref: miR-589-5p inhibits MAP3K8 and suppresses CD90(+) cancer stem cells in hepatocellular carcinoma. PMID: 27835990 Ref: The Emerging Roles of Long Noncoding RNA ROR (lincRNA-ROR) and its Possible Mechanisms in Human Cancers. PMID: 27855392 Ref: LncRNA Sox2ot overexpression serves as a poor prognostic biomarker in gastric cancer. PMID: 27904704 |
Ref: Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique. PMID: 27728962 Ref: Loss of miR-638 promotes invasion and epithelial-mesenchymal transition by targeting SOX2 in hepatocellular carcinoma. PMID: 27878280 Ref: MBD3 inhibits formation of liver cancer stem cells. PMID: 27894081 Ref: HBx drives alpha fetoprotein expression to promote initiation of liver cancer stem cells through activating PI3K/AKT signal pathway. PMID: 27925189 Ref: Integrin beta4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma. PMID: 28084395 Ref: Transcriptional activation of PD-L1 by Sox2 contributes to the proliferation of hepatocellular carcinoma cells. PMID: 28339084 Ref: Hepatitis B virus PreS1 facilitates hepatocellular carcinoma development by promoting appearance and self-renewal of liver cancer stem cells. PMID: 28455240 Ref: Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. PMID: 28581518 Ref: Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis. PMID: 28794048 Ref: LncRNA SOX2-OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2. PMID: 28960757 Ref: Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors. PMID: 28964793 Ref: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma. PMID: 29025375 Ref: Mitophagy Controls the Activities of Tumor Suppressor p53 to Regulate Hepatic Cancer Stem Cells. PMID: 29033320 Ref: High-mobility-group protein 2 regulated by microRNA-127 and small heterodimer partner modulates pluripotency of mouse embryonic stem cells and liver tumor initiating cells. PMID: 29218329 Ref: [Effects of aqueous extracts of gecko on stemness of hepatocellular carcinoma]. PMID: 29243438 Ref: Pluripotency transcription factors and Metabolic reprogramming of mitochondria in tumor-initiating stem-like cells. PMID: 29256636 |
Ref: NF-kappaB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite. PMID: 29240254 Ref: Immunohistochemical and Biochemical Expression Patterns of TTF-1, RAGE, GLUT-1 and SOX2 in HCV-Associated Hepatocellular Carcinomas PMID: 29373917 Ref: Ovatodiolide suppresses yes-associated protein 1-modulated cancer stem cell phenotypes in highly malignant hepatocellular carcinoma and sensitizes cancer cells to chemotherapy in vitro. PMID: 29698666 Ref: Expression of microRNA 638 and sex-determining region Y-box 2 in hepatocellular carcinoma: Association between clinicopathological features and prognosis. PMID: 29731884 Ref: Downregulation of Cancer Stemness by Novel Diterpenoid Ovatodiolide Inhibits Hepatic Cancer Stem Cell-Like Traits by Repressing Wnt/[Formula: see text]-Catenin Signaling. PMID: 29792038 Ref: Effect of Bmi-1-mediated NF-kappaB signaling pathway on the stem-like properties of CD133+ human liver cancer cells. PMID: 29843222 Ref: A novel TGF-beta and H19 signaling axis in tumor-initiating hepatocytes that regulates hepatic carcinogenesis. PMID: 30014520 Ref: Homeobox containing 1 inhibits liver cancer progression by promoting autophagy as well as inhibiting stemness and immune escape. PMID: 30015890 Ref: Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway. PMID: 30018710 Ref: Blocking CDK1/PDK1/beta-Catenin signaling by CDK1 inhibitor RO3306 increased the efficacy of sorafenib treatment by targeting cancer stem cells in a preclinical model of hepatocellular carcinoma. PMID: 30083256 |