Primary Site >> Colorectal Cancer
Gene >> SOX2
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Ref: Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression. PMID: 17136346 Ref: Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. PMID: 17611704 Ref: Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. PMID: 17671748 |
Ref: Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions. PMID: 18027866 |
Ref: Comprehensive analysis of the clinical significance of inducing pluripotent stemness-related gene expression in colorectal cancer cells. PMID: 19554373 Ref: Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. PMID: 19657699 Ref: The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. PMID: 19935649 |
Ref: CD133 expression predicts for non-response to chemotherapy in colorectal cancer. PMID: 20081809 Ref: New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells. PMID: 20630067 Ref: ChIP-seq and Functional Analysis of the SOX2 Gene in Colorectal Cancers. PMID: 20726776 Ref: ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers. PMID: 20726797 |
Ref: Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells. PMID: 21435460 Ref: LIN28B promotes colon cancer progression and metastasis. PMID: 21512136 Ref: SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer. PMID: 22168803 |
Ref: OCT4 spliced variant OCT4B1 is expressed in human colorectal cancer. PMID: 21480394 Ref: Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells. PMID: 22205615 Ref: Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer. PMID: 22293932 Ref: Ascl2 knockdown results in tumor growth arrest by miRNA-302b-related inhibition of colon cancer progenitor cells. PMID: 22384170 Ref: Dicer 1, ribonuclease type III modulates a reprogramming effect in colorectal cancer cells. PMID: 22446887 Ref: MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. PMID: 22641368 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells. PMID: 22902753 Ref: Silencing SOX2 induced mesenchymal-epithelial transition and its expression predicts liver and lymph node metastasis of CRC patients. PMID: 22912670 Ref: Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer. PMID: 22989882 |
Ref: N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. PMID: 22854319 Ref: Colorectal micropapillary carcinomas are associated with poor prognosis and enriched in markers of stem cells. PMID: 23060121 Ref: NANOG modulates stemness in human colorectal cancer. PMID: 23085761 Ref: MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2. PMID: 23111103 Ref: Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFbeta1-targeting peptides P17 and P144. PMID: 23153552 Ref: SSEA-3 as a novel amplifying cancer cell surface marker in colorectal cancers. PMID: 23175153 Ref: A signature for induced pluripotent stem cell-associated genes in colorectal cancer. PMID: 23307247 Ref: Autophagy and cellular senescence mediated by Sox2 suppress malignancy of cancer cells. PMID: 23451179 Ref: Excellence in cell signaling research recognized with major new award. PMID: 23497077 Ref: Prognostic value of changes in the expression of stem cell markers in the peripheral blood of patients with colon cancer. PMID: 23545848 Ref: Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugs. PMID: 23736004 Ref: Salinomycin induces apoptosis in cisplatin-resistant colorectal cancer cells by accumulation of reactive oxygen species. PMID: 23916687 Ref: Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines. PMID: 24023739 Ref: In vitro characterization of stem cell-like properties of drug-resistant colon cancer subline. PMID: 24330852 Ref: AP-1 Gene Expression Levels May Be Correlated with Changes in Gene Expression of Some Stemness Factors in Colon Carcinomas. PMID: 24396595 |
Ref: Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism. PMID: 24658157 Ref: IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. PMID: 24816405 Ref: ZNF281/ZBP-99: a new player in epithelial-mesenchymal transition, stemness, and cancer. PMID: 24838609 Ref: Loss of miR-638 in vitro promotes cell invasion and a mesenchymal-like transition by influencing SOX2 expression in colorectal carcinoma cells. PMID: 24885288 Ref: Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells. PMID: 24921652 Ref: Characterization of side population cells isolated from the colon cancer cell line SW480. PMID: 24926880 Ref: HER2-signaling pathway, JNK and ERKs kinases, and cancer stem-like cells are targets of Bozepinib small compound. PMID: 24946763 Ref: Induction of cancer stem cell properties in colon cancer cells by defined factors. PMID: 25006808 Ref: SOX2 expression is regulated by BRAF and contributes to poor patient prognosis in colorectal cancer. PMID: 25010701 Ref: Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression. PMID: 25108707 Ref: Stress response protein cirp links inflammation and tumorigenesis in colitis-associated cancer. PMID: 25187386 Ref: Potential role for the Metnase transposase fusion gene in colon cancer through the regulation of key genes. PMID: 25333365 Ref: Preoperative low dose NSAID treatment influences the genes for stemness, growth, invasion and metastasis in colorectal cancer. PMID: 25340937 |
Ref: A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer: Research for Reprogramming of Cancer Cells by MicroRNAs. PMID: 25384704 Ref: Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells. PMID: 25404486 Ref: Involvement of heat shock protein a4/apg-2 in refractory inflammatory bowel disease. PMID: 25437815 Ref: Cell-surface Vimentin: A mislocalized protein for isolating csVimentin(+) CD133(-) novel stem-like hepatocellular carcinoma cells expressing EMT markers. PMID: 25487874 Ref: Lithium chloride induces mesenchymaltoepithelial reverting transition in primary colon cancer cell cultures. PMID: 25738332 Ref: Pluripotency transcription factors in the pathogenesis of colorectal cancer and implications for prognosis. PMID: 25808439 Ref: The SOX17/miR-371-5p/SOX2 axis inhibits EMT, stem cell properties and metastasis in colorectal cancer. PMID: 25868860 Ref: The prognostic value of the stem-like group in colorectal cancer using a panel of immunohistochemistry markers. PMID: 25906747 Ref: miR-21 and miR-145 cooperation in regulation of colon cancer stem cells. PMID: 25928322 Ref: Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo. PMID: 25941936 Ref: Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells. PMID: 25964982 Ref: MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells. PMID: 25970424 Ref: Identification of a distinct population of CD133(+)CXCR4(+) cancer stem cells in ovarian cancer. PMID: 26020117 Ref: Correlation of HIWI and HILI Expression with Cancer Stem Cell Markers in Colorectal Cancer. PMID: 26026091 Ref: Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer. PMID: 26106421 Ref: Simultaneous inhibition of EGFR/VEGFR and cyclooxygenase-2 targets stemness-related pathways in colorectal cancer cells. PMID: 26107817 Ref: Different Effects of BORIS/CTCFL on Stemness Gene Expression, Sphere Formation and Cell Survival in Epithelial Cancer Stem Cells. PMID: 26185996 Ref: MiR-106b induces cell radioresistance via the PTEN/PI3K/AKT pathways and p21 in colorectal cancer. PMID: 26238857 Ref: Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice. PMID: 26261008 Ref: B7H1 Expression and Epithelial-To-Mesenchymal Transition Phenotypes on Colorectal Cancer Stem-Like Cells. PMID: 26284927 Ref: Verification of ALDH Activity as a Biomarker in Colon Cancer Stem Cells-Derived HT-29 Cell Line. PMID: 26634106 Ref: Comparison of gene expression of SOX2 and OCT4 in normal tissue, polyps, and colon adenocarcinoma using immunohistochemical staining. PMID: 26645019 |
Ref: Isolation of colorectal cancer stem-like cells. PMID: 25535115 Ref: In vivo epigenetic reprogramming of primary human colon cancer cells enhances metastases. PMID: 26031752 Ref: Physcion inhibits the metastatic potential of human colorectal cancer SW620 cells in vitro by suppressing the transcription factor SOX2. PMID: 26707141 Ref: What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. PMID: 26745821 Ref: miR-450b-5p Suppresses Stemness and the Development of Chemoresistance by Targeting SOX2 in Colorectal Cancer. PMID: 26845645 Ref: Target beta-catenin/CD44/Nanog axis in colon cancer cells by certain N'-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides. PMID: 26944615 Ref: Yin Yang 1 is associated with cancer stem cell transcription factors (SOX2, OCT4, BMI1) and clinical implication. PMID: 27225481 Ref: The Effect of Analogues of 1alpha,25-Dihydroxyvitamin D(2) on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil. PMID: 27314328 Ref: Prognostic value of Sox2 expression in digestive tract cancers: A meta-analysis. PMID: 27376796 Ref: SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. PMID: 27411517 |
Ref: Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and beta-Catenin Signaling. PMID: 27983919 Ref: The Identifications and Clinical Implications of Cancer Stem Cells in Colorectal Cancer. PMID: 28237538 Ref: Targeting colon cancer stem cells with novel blood cholesterol drug pitavastatin. PMID: 28387909 Ref: Phenethyl isothiocyanate suppresses cancer stem cell properties in vitro and in a xenograft model. PMID: 28545668 Ref: Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue. PMID: 28596815 Ref: Cholesterol Enhances Colorectal Cancer Progression via ROS Elevation and MAPK Signaling Pathway Activation. PMID: 28618417 Ref: The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition. PMID: 28710230 Ref: Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers. PMID: 28833104 Ref: SATB2/beta-catenin/TCF-LEF pathway induces cellular transformation by generating cancer stem cells in colorectal cancer. PMID: 28887549 Ref: Clinical significance of Fusobacterium nucleatum, epithelial-mesenchymal transition, and cancer stem cell markers in stage III/IV colorectal cancer patients. PMID: 29081665 Ref: The prognostic value of cancer stem-like cell markers SOX2 and CD133 in stage III colon cancer is modified by expression of the immune-related markers FoxP3, PD-L1 and CD3. PMID: 29102042 Ref: Sox2 modulates motility and enhances progression of colorectal cancer via the Rho-ROCK signaling pathway. PMID: 29228716 Ref: Commensal-infected macrophages induce dedifferentiation and reprogramming of epithelial cells during colorectal carcinogenesis. PMID: 29254234 Ref: Characterization of Cancer Stem Cells in Colon Adenocarcinoma Metastasis to the Liver. PMID: 29404335 |
Ref: Correlation of Cancer Stem-Cell Markers OCT4, SOX2, and NANOG with Clinicopathological Features and Prognosis in Operative Patients with Rectal Cancer. PMID: 29214774 Ref: Transglutaminase 2 Regulates Self-renewal and Stem Cell Marker of Human Colorectal Cancer Stem Cells. PMID: 29374703 Ref: Ectopic expression of miR-147 inhibits stem cell marker and epithelial-mesenchymal transition (EMT)-related protein expression in colon cancer cells. PMID: 29426374 Ref: New histone demethylase LSD1 inhibitor selectively targets teratocarcinoma and embryonic carcinoma cells. PMID: 29439916 Ref: Long noncoding RNA CCAT2 is activated by E2F1 and exerts oncogenic properties by interacting with PTTG1 in pituitary adenomas. PMID: 29511595 Ref: Extracted metabolite from Streptomyces Levis ABRIINW111 altered the gene expression in colon cancer. PMID: 29564063 Ref: Phthalate exposure promotes chemotherapeutic drug resistance in colon cancer cells. PMID: 29568348 Ref: Lgr5+CD44+EpCAM+ Strictly Defines Cancer Stem Cells in Human Colorectal Cancer. PMID: 29627827 Ref: [LincRNA-ROR functions as a ceRNA to regulate Oct4, Sox2, and Nanog expression by sponging miR-145 and its effect on biologic characteristics of colonic cancer stem cells]. PMID: 29690669 Ref: Assessing stemness and proliferation properties of the newly established colon cancer 'stem' cell line, CSC480 and novel approaches to identify dormant cancer cells. PMID: 29693155 Ref: Protein arginine methyltransferase 8 gene enhances the colon cancer stem cell (CSC) function by upregulating the pluripotency transcription factor. PMID: 29721049 Ref: Salvianolic acid B reverses multidrug resistance in nude mice bearing human colon cancer stem cells. PMID: 29845279 Ref: DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. PMID: 29869821 Ref: IL-1beta promotes the nuclear translocaiton of S100A4 protein in gastric cancer cells MGC803 and the cell's stem-like properties through PI3K pathway. PMID: 29932233 Ref: The pluripotency network in colorectal cancer pathogenesis and prognosis: an update. PMID: 29944017 Ref: Tumour suppressor properties of miR-15a and its regulatory effects on BCL2 and SOX2 proteins in colorectal carcinomas. PMID: 29958837 Ref: miR-106a Reduces 5-Fluorouracil (5-FU) Sensitivity of Colorectal Cancer by Targeting Dual-Specificity Phosphatases 2 (DUSP2). PMID: 30011263 Ref: Melatonin and 5-fluorouracil co-suppress colon cancer stem cells by regulating cellular prion protein-Oct4 axis. PMID: 30091203 Ref: PR-LncRNA signature regulates glioma cell activity through expression of SOX factors. PMID: 30143669 Ref: Prognostic value of long noncoding RNAs in gastric cancer: a meta-analysis. PMID: 30147339 Ref: Three-Dimensional Ameliorated Biologics Elicit Thymic Renewal in Tumor-Bearing Hosts. PMID: 30150284 Ref: LGR5, a novel functional glioma stem cell marker, promotes EMT by activating the Wnt/beta-catenin pathway and predicts poor survival of glioma patients. PMID: 30208924 Ref: The anti-metastatic effect of ginsenoside Rb2 in colorectal cancer in an EGFR/SOX2-dependent manner. PMID: 30264477 Ref: Solasodine reverses stemness and epithelial-mesenchymal transition in human colorectal cancer. PMID: 30268504 Ref: Cell biological profiling of reprogrammed cancer stem cell-like colon cancer cells maintained in culture. PMID: 30284085 Ref: MiR-30-5p suppresses cell chemoresistance and stemness in colorectal cancer through USP22/Wnt/beta-catenin signaling axis. PMID: 30338942 |