Primary Site >> Colorectal Cancer
Gene >> SMURF1
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Ref: Hypoxia induces p53-dependent transactivation and Fas/CD95-dependent apoptosis. PMID: 16917513 |
Ref: CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation. PMID: 23995790 Ref: The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis. PMID: 24821572 Ref: TRIB2 inhibits Wnt/beta-Catenin/TCF4 signaling through its associated ubiquitin E3 ligases, beta-TrCP, COP1 and Smurf1, in liver cancer cells. PMID: 25311538 |
Ref: miRNA-497 Enhances the Sensitivity of Colorectal Cancer Cells to Neoadjuvant Chemotherapeutic Drug. PMID: 25929865 Ref: IKKbeta acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. PMID: 26621452 |
Ref: Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation. PMID: 28408404 |
Ref: IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress. PMID: 29753111 |