Primary Site >> Colorectal Cancer
Gene >> SMAD7
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Ref: Combined copy status of 18q21 genes in colorectal cancer shows frequent retention of SMAD7. PMID: 11391794 Ref: Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors. PMID: 11536370 |
Ref: Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene. PMID: 12557227 Ref: Exclusion of Madh2, Madh4, and Madh7 as candidates for the modifier of Min 2 (Mom2) locus. PMID: 12584607 Ref: SMAD7 is a prognostic marker in patients with colorectal cancer. PMID: 12584741 Ref: Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. PMID: 12866583 |
Ref: Epstein-barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with epstein-barr virus-negative carcinoma. PMID: 15014022 |
Ref: Smad7 induces tumorigenicity by blocking TGF-beta-induced growth inhibition and apoptosis. PMID: 15922743 Ref: Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-beta1/Smad pathway. PMID: 15963949 |
Ref: Role of Smad proteins in the regulation of NF-kappaB by TGF-beta in colon cancer cells. PMID: 16288847 |
Ref: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. PMID: 17934461 |
Ref: Lack of a relationship between the common 18q24 variant rs12953717 and risk of chronic lymphocytic leukemia. PMID: 18231913 Ref: Smad7 induces hepatic metastasis in colorectal cancer. PMID: 18781153 |
Ref: Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. PMID: 19155440 Ref: Association of common genetic variants in SMAD7 and risk of colon cancer. PMID: 19357349 Ref: The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression. PMID: 19395656 Ref: No breast cancer association for transforming growth factor-beta pathway colorectal cancer single nucleotide polymorphisms. PMID: 19505925 |
Ref: Increased risk of colon cancer associated with a genetic polymorphism of SMAD7. PMID: 20124488 Ref: Role of TGF-beta1, its receptor TGFbetaRII, and Smad proteins in the progression of colorectal cancer. PMID: 20165854 Ref: Tgf-beta signaling alterations and colon cancer. PMID: 20517689 |
Ref: SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study. PMID: 21075068 Ref: A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population. PMID: 21221812 Ref: Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population. PMID: 21242260 Ref: Genetic variation in the transforming growth factor-beta signaling pathway and survival after diagnosis with colon and rectal cancer. PMID: 21365634 Ref: Common colorectal cancer risk variants in SMAD7 are associated with survival among prediagnostic nonsteroidal anti-inflammatory drug users: a population-based study of postmenopausal women. PMID: 21910156 Ref: Smad7 expression in T cells prevents colitis-associated cancer. PMID: 22028324 |
Ref: Characterization of gene-environment interactions for colorectal cancer susceptibility loci. PMID: 22367214 Ref: A common SMAD7 variant is associated with risk of colorectal cancer: evidence from a case-control study and a meta-analysis. PMID: 22457752 Ref: Association between colorectal cancer susceptibility loci and survival time after diagnosis with colorectal cancer. PMID: 22580541 Ref: Cancer in inflammatory bowel disease: lessons from animal models. PMID: 22614440 Ref: Reprogramming the immune system in IBD. PMID: 22796803 Ref: Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. PMID: 23019048 |
Ref: Phenotypic and tumor molecular characterization of colorectal cancer in relation to a susceptibility SMAD7 variant associated with survival. PMID: 23104301 Ref: Genetic variations in the TGFbeta signaling pathway, smoking and risk of colorectal cancer in a Chinese population. PMID: 23275154 Ref: MicroRNA-25 functions as a potential tumor suppressor in colon cancer by targeting Smad7. PMID: 23435373 Ref: Association of SMAD7 rs12953717 polymorphism with cancer: a meta-analysis. PMID: 23472153 Ref: Genetic variations in SMAD7 are associated with colorectal cancer risk in the colon cancer family registry. PMID: 23560096 Ref: Relationship of TGF-beta1 and Smad7 expression with decreased dendritic cell infiltration in liver gastrointestinal cancer metastasis. PMID: 23998914 Ref: SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PMID: 24066093 Ref: Genes and SNPs associated with non-hereditary and hereditary colorectal cancer. PMID: 24289550 |
Ref: SMAD7 rs12953717 polymorphism contributes to increased risk of colorectal cancer. PMID: 23949881 Ref: Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. PMID: 24448986 Ref: Smad7 induces plasticity in tumor-infiltrating Th17 cells and enables TNF-alpha-mediated killing of colorectal cancer cells. PMID: 24480808 Ref: A functional role for Smad7 in sustaining colon cancer cell growth and survival. PMID: 24556688 Ref: Shared and independent colorectal cancer risk alleles in TGFbeta-related genes in African and European Americans. PMID: 24753543 Ref: Lack of influence of the SMAD7 gene rs2337107 polymorphism on risk of colorectal cancer in an Iranian population. PMID: 24969865 Ref: S-allylmercaptocysteine promotes MAPK inhibitor-induced apoptosis by activating the TGF-beta signaling pathway in cancer cells. PMID: 24970681 Ref: Polymorphism of SMAD7 gene (rs2337104) and risk of colorectal cancer in an Iranian population: a case-control study. PMID: 25289133 Ref: Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype. PMID: 25375357 |
Ref: Colorectal cancer-susceptibility single-nucleotide polymorphisms in Korean population. PMID: 23875689 Ref: Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population. PMID: 24557062 Ref: MicroRNA-93 suppress colorectal cancer development via Wnt/beta-catenin pathway downregulating. PMID: 25371073 Ref: Intronic polymorphisms of the SMAD7 gene in association with colorectal cancer. PMID: 25640388 Ref: miR-1269 promotes metastasis and forms a positive feedback loop with TGF-beta. PMID: 25872451 Ref: Correlation Between CASC8, SMAD7 Polymorphisms and the Susceptibility to Colorectal Cancer: An Updated Meta-Analysis Based on GWAS Results. PMID: 26579801 Ref: IKKbeta acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis. PMID: 26621452 |
Ref: A subset of genetic susceptibility variants for colorectal cancer also has prognostic value. PMID: 25963333 Ref: Are SMAD7 rs4939827 and CHI3L1 rs4950928 polymorphisms associated with colorectal cancer in Egyptian patients? PMID: 26779637 Ref: Genomic characterization of liver metastases from colorectal cancer patients. PMID: 27662660 Ref: Expression of VEGF-D, SMAD4, and SMAD7 and Their Relationship with Lymphangiogenesis and Prognosis in Colon Cancer. PMID: 27730400 Ref: SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies. PMID: 28070019 |
Ref: Genetic variants in the TGFbeta-signaling pathway influence expression of miRNAs in colon and rectal normal mucosa and tumor tissue. PMID: 28061442 Ref: miR-4775 promotes colorectal cancer invasion and metastasis via the Smad7/TGFbeta-mediated epithelial to mesenchymal transition. PMID: 28095858 Ref: A low-frequency variant in SMAD7 modulates TGF-beta signaling and confers risk for colorectal cancer in Chinese population. PMID: 28218435 Ref: Smad7 knockdown activates protein kinase RNA-associated eIF2alpha pathway leading to colon cancer cell death. PMID: 28300830 Ref: SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population. PMID: 28467803 Ref: Identification of hypoxia-regulated angiogenic genes in colorectal cancer. PMID: 28928094 Ref: MicroRNA-binding site polymorphisms in genes involved in colorectal cancer etiopathogenesis and their impact on disease prognosis. PMID: 29048575 Ref: The RS4939827 polymorphism in the SMAD7 GENE and its association with Mediterranean diet in colorectal carcinogenesis. PMID: 29084532 Ref: JAB1-STAT3 activation loop is associated with recurrence following 5-fluorouracil-based adjuvant chemotherapy in human colorectal cancer. PMID: 29113268 Ref: Bayesian and frequentist analysis of an Austrian genome-wide association study of colorectal cancer and advanced adenomas. PMID: 29228715 Ref: Upregulation of NETO2 gene in colorectal cancer. PMID: 29297384 |
Ref: Impact of microRNA-375 and its target gene SMAD-7 polymorphism on susceptibility of colorectal cancer. PMID: 28374902 Ref: Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery. PMID: 29065840 Ref: Colorectal cancer susceptibility loci as predictive markers of rectal cancer prognosis after surgery. PMID: 29119627 Ref: Transforming Growth Factor-beta1/Smad7 in Intestinal Immunity, Inflammation, and Cancer. PMID: 29973939 Ref: Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort. PMID: 29986644 Ref: MiR-92a promotes tumorigenesis of colorectal cancer, a transcriptomic and functional based study. PMID: 30119209 Ref: EGFR, SMAD7, and TGFBR2 Polymorphisms Are Associated with Colorectal Cancer in Patients with Lynch Syndrome. PMID: 30275229 Ref: TrkC-miR2 regulates TGFbeta signaling pathway through targeting of SMAD3 transcript. PMID: 30304551 |