Primary Site >> Esophagus Cancer

Gene >> SMAD4

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Ref: Infrequent DPC4 gene mutation in esophageal cancer, gastric cancer and ulcerative colitis-associated neoplasms.
PMID: 8957088
 Ref: Mutation analysis of transforming growth factor beta type II receptor, Smad2, Smad3 and Smad4 in esophageal squamous cell carcinoma.
PMID: 10995883
 Ref: Differences in Smad4 expression in human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck squamous cell carcinoma.
PMID: 15867212
 Ref: Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
PMID: 17591695
 Ref: Genome-wide copy number analysis in esophageal adenocarcinoma using high-density single-nucleotide polymorphism arrays.
PMID: 18519675
 Ref: Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes.
PMID: 21734802
 Ref: Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
PMID: 23525077
 Ref: Aberrant methylation and decreased expression of the TGF-beta/Smad target gene FBXO32 in esophageal squamous cell carcinoma.
PMID: 24798237
 Ref: Esophageal cancer in a family with hamartomatous tumors and germline PTEN frameshift and SMAD7 missense mutations.
PMID: 25554686
Ref: Tumor profiling of gastric and esophageal carcinoma reveal different treatment options.
PMID: 25778705
Ref: Expression of Smad4, TGF-betaRII, and p21waf1 in esophageal squamous cell carcinoma tissue.
PMID: 26137158
Ref: Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences.
PMID: 26336083
 Ref: Distinct esophageal adenocarcinoma molecular subtype has subtype-specific gene expression and mutation patterns.
PMID: 30355311