Primary Site >> Biliary tract Cancer

Overview

Mutation

Expression

Methylation

Prognosis

Literature

Timeline

Gene >> SMAD2

2013	2017	2018
Ref: 15-hydroxyprostaglandin dehydrogenase-derived 15-keto-prostaglandin E2 inhibits cholangiocarcinoma cell growth through interaction with peroxisome proliferator-activated receptor-gamma, SMAD2/3, and TAP63 proteins. PMID: 23687300 Ref: JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. PMID: 24100678	Ref: Altered Expression of Hippo Signaling Pathway Molecules in Intrahepatic Cholangiocarcinoma. PMID: 28448997 Ref: Blocking ERK1/2 signaling impairs TGF-beta1 tumor promoting function but enhances its tumor suppressing role in intrahepatic cholangiocarcinoma cells. PMID: 28959141	Ref: CD133 expression in cancer cells predicts poor prognosis of non-mucin producing intrahepatic cholangiocarcinoma. PMID: 29510695 Ref: S100A11 promotes TGF-beta1-induced epithelial-mesenchymal transition through SMAD2/3 signaling pathway in intrahepatic cholangiocarcinoma. PMID: 29569474 Ref: S100A11 promotes cell proliferation via P38/MAPK signaling pathway in intrahepatic cholangiocarcinoma. PMID: 30182496