Primary Site >> Colorectal Cancer

Gene >> SLC9A3R1

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Ref: EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.
PMID: 12830000
 Ref: NHERF1/EBP50 is a new marker in colorectal cancer.
PMID: 21170265
 Ref: Expression of NHERF1 in colonic tumors induced by 1,2-dimethylhydrazine in rats is independent of plasma ovarian steroids.
PMID: 21761111
 Ref: Overexpression of nuclear NHERF1 in advanced colorectal cancer: association with hypoxic microenvironment and tumor invasive phenotype.
PMID: 22440733
Ref: Aberrant nuclear localization of EBP50 promotes colorectal carcinogenesis in xenotransplanted mice by modulating TCF-1 and beta-catenin interactions.
PMID: 22466651
Ref: Involvement of nuclear NHERF1 in colorectal cancer progression.
PMID: 22766563
 Ref: High density of tryptase-positive mast cells in human colorectal cancer: a poor prognostic factor related to protease-activated receptor 2 expression.
PMID: 23991686
Ref: PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system.
PMID: 24348097
 Ref: NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
PMID: 24862762
Ref: The prognostic value of the Na(+)/ H(+) exchanger regulatory factor 1 (NHERF1) protein in cancer.
PMID: 24878819
 Ref: Deletion of Na+/H+ exchanger regulatory factor 2 represses colon cancer progress by suppression of Stat3 and CD24.
PMID: 26867566
Ref: NHERF1/EBP50 Suppresses Wnt-beta-Catenin Pathway-Driven Intestinal Neoplasia.
PMID: 27566107
Ref: beta-catenin interaction with NHERF1 and RASSF1A methylation in metastatic colorectal cancer patients.
PMID: 27765918
 Ref: NHERF1 regulates the progression of colorectal cancer through the interplay with VEGFR2 pathway.
PMID: 27999191
 Ref: Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.
PMID: 29520890
Ref: beta-catenin knockdown promotes NHERF1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy.
PMID: 29551770
Ref: Multilayered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/betacatenin signaling activation (Review).
PMID: 29786110
Ref: Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
PMID: 29901158