Primary Site >> Stomach Cancer
Gene >> SLC7A11
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Ref: CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth. PMID: 21397861 |
Ref: Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia. PMID: 23848514 |
Ref: Analysis of circulating tumor cells derived from advanced gastric cancer. PMID: 25622566 |
Ref: Inhibition of Prostaglandin Reductase 2, a Putative Oncogene Overexpressed in Human Pancreatic Adenocarcinoma, Induces Oxidative Stress-Mediated Cell Death Involving xCT and CTH Gene Expressions through 15-Keto-PGE2. PMID: 26820738 Ref: Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2alpha-ATF4-xCT pathway. PMID: 27708226 |
Ref: Dose-escalation study for the targeting of CD44v(+) cancer stem cells by sulfasalazine in patients with advanced gastric cancer (EPOC1205). PMID: 27055559 Ref: Decreased expression of the long non-coding RNA SLC7A11-AS1 predicts poor prognosis and promotes tumor growth in gastric cancer. PMID: 29348845 |
Ref: Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells. PMID: 30333913 Ref: Activated Integrated Stress Response Induced by Salubrinal Promotes Cisplatin Resistance in Human Gastric Cancer Cells via Enhanced xCT Expression and Glutathione Biosynthesis. PMID: 30380689 |