Primary Site >> Colorectal Cancer
Gene >> SLC2A1
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Ref: Expression and localization of GLUT-5 in Caco-2 cells, human small intestine, and colon. PMID: 1384349 |
Ref: Overexpression of the human erythrocyte glucose transporter occurs as a late event in human colorectal carcinogenesis and is associated with an increased incidence of lymph node metastases. PMID: 9816281 |
Ref: GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. PMID: 9655290 |
Ref: Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice. PMID: 10025844 |
Ref: Expression of facilitative glucose transporter 1 mRNA in colon cancer was not regulated by k-ras. PMID: 10806301 |
Ref: Glut1 expression in T1 and T2 stage colorectal carcinomas: its relationship to clinicopathological features. PMID: 11166147 Ref: Clinical significance of human erythrocyte glucose transporter 1 expression at the deepest invasive site of advanced colorectal carcinoma. PMID: 11244332 Ref: Using positron emission tomography with [(18)F]FDG to predict tumor behavior in experimental colorectal cancer. PMID: 11494112 |
Ref: Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells. PMID: 12381735 Ref: Glucose transporter-1 (GLUT-1): a potential marker of prognosis in rectal carcinoma? PMID: 12942120 |
Ref: Early colon cancers detected by FDG-pet: a report of two cases with immunohistochemical investigation. PMID: 15362743 |
Ref: Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase. PMID: 15656581 Ref: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. PMID: 15896711 |
Ref: Hypoxia in relation to vasculature and proliferation in liver metastases in patients with colorectal cancer. PMID: 16242253 Ref: Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. PMID: 16423989 Ref: Hypoxia-induced up-regulation of angiopoietin-2 in colorectal cancer. PMID: 16525658 Ref: Endogenous markers of hypoxia/anaerobic metabolism and anemia in primary colorectal cancer. PMID: 16827797 Ref: The impact of surgically induced ischaemia on protein levels in patients undergoing rectal cancer surgery. PMID: 17016487 Ref: Correlation of GLUT-1 overexpression, tumor size, and depth of invasion with 18F-2-fluoro-2-deoxy-D-glucose uptake by positron emission tomography in colorectal cancer. PMID: 17080242 |
Ref: Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. PMID: 16797120 Ref: 18F-FDG PET and PET/CT in fever of unknown origin. PMID: 17204697 Ref: Clinicopathological significance and linkage of the distribution of HIF-1alpha and GLUT-1 in human primary colorectal cancer. PMID: 17387384 Ref: Significant coexpression of GLUT-1, Bcl-xL, and Bax in colorectal cancer. PMID: 17404017 Ref: 1alpha,25-dihydroxyvitamin D3 (Calcitriol) inhibits hypoxia-inducible factor-1/vascular endothelial growth factor pathway in human cancer cells. PMID: 17431122 Ref: Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. PMID: 17452775 Ref: 18F-FDG PET scanning correlates with tissue markers of poor prognosis and predicts mortality for patients after liver resection for colorectal metastases. PMID: 17475966 Ref: Possible mechanism for the regulation of glucose on proliferation, inhibition and apoptosis of colon cancer cells induced by sodium butyrate. PMID: 17663521 Ref: Serum lactate dehydrogenase levels and glycolysis significantly correlate with tumor VEGFA and VEGFR expression in metastatic CRC patients. PMID: 18086000 |
Ref: Extracellular matrix and HIF-1 signaling: the role of prolidase. PMID: 17999410 Ref: Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers. PMID: 18097579 Ref: Presence of HIF-1 and related genes in normal mucosa, adenomas and carcinomas of the colorectum. PMID: 18351386 Ref: The role of hypoxia in recurrence following resection of Dukes' B colorectal cancer. PMID: 18594846 Ref: Colorectal tumor vascularity: quantitative assessment with multidetector CT--do tumor perfusion measurements reflect angiogenesis? PMID: 18812560 |
Ref: Relations of TGF-beta1 with HIF-1 alpha, GLUT-1 and longer survival of colorectal cancer patients. PMID: 19142800 Ref: Expression patterns of hypoxic markers at the invasive margin of colorectal cancers and liver metastases. PMID: 19540709 Ref: GLUT-1 expression and response to chemoradiotherapy in rectal cancer. PMID: 19569052 Ref: GLUT1 gene is a potential hypoxic marker in colorectal cancer patients. PMID: 19619276 Ref: Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. PMID: 19661383 Ref: Up-regulation of Kruppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha. PMID: 19671674 Ref: The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts. PMID: 19843666 |
Ref: High 18F-FDG uptake in microscopic peritoneal tumors requires physiologic hypoxia. PMID: 20351353 Ref: GLUT1 and Bcl-xL in relation to erythropoietin in human colorectal adenocarcinomas. PMID: 21033220 |
Ref: Smad4 inactivation promotes malignancy and drug resistance of colon cancer. PMID: 21245094 Ref: Cellular prion protein promotes glucose uptake through the Fyn-HIF-2alpha-Glut1 pathway to support colorectal cancer cell survival. PMID: 21265952 Ref: Pronounced tumour regression after radiotherapy is associated with negative/weak glucose transporter-1 expression in rectal cancer. PMID: 21273616 Ref: Pretreatment HIF-1alpha and GLUT-1 expressions do not correlate with outcome after preoperative chemoradiotherapy in rectal cancer. PMID: 21617210 Ref: Overexpression of GLUT1 in colorectal cancer is independently associated with poor prognosis. PMID: 21786248 Ref: Evidence for cardiac atrophic remodeling in cancer-induced cachexia in mice. PMID: 21822537 Ref: Hypoxia signature of splice forms of tryptophanyl-tRNA synthetase marks pancreatic cancer cells with distinct metastatic abilities. PMID: 21926542 Ref: Carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 as predictors of disease outcome in rectal cancer: multivariate Cox survival models following data reduction by principal component analysis of the clinicopathological PMID: 22199327 |
Ref: Potential role of combined FDG PET/CT & contrast enhancement MRI in a rectal carcinoma model with nodal metastases characterized by a poor FDG-avidity. PMID: 21300505 Ref: Cell surface proteomics identifies glucose transporter type 1 and prion protein as candidate biomarkers for colorectal adenoma-to-carcinoma progression. PMID: 21890811 Ref: MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer. PMID: 21964914 Ref: Molecular mechanism underlying the detection of colorectal cancer by 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography. PMID: 22065316 Ref: Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. PMID: 22072148 Ref: Relationship between 18F-fluorodeoxyglucose accumulation and KRAS/BRAF mutations in colorectal cancer. PMID: 22282467 Ref: Correlations between SUVmax and expression of GLUT1 and growth factors inducing lymphangiogenesis. PMID: 22444673 Ref: The flow-metabolic phenotype of primary colorectal cancer: assessment by integrated 18F-FDG PET/perfusion CT with histopathologic correlation. PMID: 22454485 Ref: hERG1 Channels and Glut-1 as Independent Prognostic Indicators of Worse Outcome in Stage I and II Colorectal Cancer: A Pilot Study. PMID: 22496927 Ref: Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy. PMID: 22711167 Ref: Main effects and interactions of carbonic anhydrase IX, hypoxia-inducible factor-1alpha, ezrin and glucose transporter-1 in multivariate analysis for disease outcome in rectal cancer. PMID: 22843905 Ref: Hypoxia-related proteins in patients with rectal cancer undergoing neoadjuvant combined modality therapy. PMID: 22874607 Ref: Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. PMID: 22943412 Ref: Clinical procedure for colon carcinoma tissue sampling directly affects the cancer marker-capacity of VEGF family members. PMID: 23148666 Ref: Selective growth inhibition by glycogen synthase kinase-3 inhibitors in tumorigenic HeLa hybrid cells is mediated through NF-kappaB-dependent GLUT3 expression. PMID: 23552737 Ref: Relationship Between Dual-Time Point FDG PET and Immunohistochemical Parameters in Preoperative Colorectal Cancer: Preliminary Study. PMID: 24900032 |
Ref: Intratumoral expression profiling of genes involved in angiogenesis in colorectal cancer patients treated with chemotherapy plus the VEGFR inhibitor PTK787/ZK 222584 (vatalanib). PMID: 22664478 Ref: Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. PMID: 22847606 Ref: Investigation of possible endogenous hypoxia markers in colorectal cancer. PMID: 22852555 Ref: Immunohistological expression of HIF-1alpha, GLUT-1, Bcl-2 and Ki-67 in consecutive biopsies during chemoradiotherapy in patients with rectal cancer. PMID: 23030583 Ref: The influence of tissue ischemia on biomarker expression in colorectal cancer. PMID: 23060299 Ref: Monitoring the effects of bevacizumab beyond progression in a murine colorectal cancer model: a functional imaging approach. PMID: 23325291 Ref: Pharmacologic activation of tumor hypoxia: a means to increase tumor 2-deoxy-2-[18F]fluoro-D-glucose uptake? PMID: 23348791 Ref: A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-alpha. PMID: 23381944 Ref: Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells. PMID: 23640464 Ref: TNFalpha and IL-17 cooperatively stimulate glucose metabolism and growth factor production in human colorectal cancer cells. PMID: 23866118 Ref: Dynamic PET with (18)F-Deoxyglucose (FDG) and quantitative assessment with a two-tissue compartment model reflect the activity of glucose transporters and hexokinases in patients with colorectal tumors. PMID: 24116350 |
Ref: Molecular mechanisms of [18F]fluorodeoxyglucose accumulation in liver cancer. PMID: 24297035 Ref: (18)F-fluorodeoxyglucose uptake and tumor hypoxia: revisit (18)f-fluorodeoxyglucose in oncology application. PMID: 24699008 Ref: Monitoring hypoxia and vasculature during bevacizumab treatment in a murine colorectal cancer model. PMID: 24700751 Ref: Gender-related differences in pathological and clinical tumor response based on immunohistochemical proteins expression in rectal cancer patients treated with short course of preoperative radiotherapy. PMID: 24756926 Ref: Lack of association between KRAS mutations and 18F-FDG PET/CT in Caucasian metastatic colorectal cancer patients. PMID: 24778079 Ref: Overcoming 5-Fu resistance of colon cells through inhibition of Glut1 by the specific inhibitor WZB117. PMID: 25227787 Ref: Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells. PMID: 25320508 Ref: Regulation of 18F-FDG accumulation in colorectal cancer cells with mutated KRAS. PMID: 25453050 |
Ref: Factor inhibiting HIF1alpha (FIH-1) functions as a tumor suppressor in human colorectal cancer by repressing HIF1alpha pathway. PMID: 25602156 Ref: Warburg effect regulated by amphiregulin in the development of colorectal cancer. PMID: 25644309 Ref: An "imaging-biopsy" strategy for colorectal tumor reconfirmation by multipurpose paramagnetic quantum dots. PMID: 25701028 Ref: Inter- and intra-tumoral relationships between vasculature characteristics, GLUT1 and budding in colorectal carcinoma. PMID: 25811313 Ref: Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. PMID: 26160839 Ref: The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types. PMID: 26169282 Ref: Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. PMID: 26317652 Ref: Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. PMID: 26541605 |
Ref: Glucose Transporter 1 (SLC2A1) and Vascular Endothelial Growth Factor A (VEGFA) Predict Survival After Resection of Colorectal Cancer Liver Metastasis. PMID: 25563886 Ref: A prognostic classifier for patients with colorectal cancer liver metastasis, based on AURKA, PTGS2 and MMP9. PMID: 26497206 Ref: Galactose conjugated platinum(II) complex targeting the Warburg effect for treatment of non-small cell lung cancer and colon cancer. PMID: 26807543 Ref: Cyanine-based 1-amino-1-deoxyglucose as fluorescent probes for glucose transporter mediated bioimaging. PMID: 27033602 Ref: New [(eta(5)-C5H5)Ru(N-N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes. PMID: 27216868 Ref: Dynamic Contrast Enhanced MRI Assessing the Antiangiogenic Effect of Silencing HIF-1alpha with Targeted Multifunctional ECO/siRNA Nanoparticles. PMID: 27264671 Ref: Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. PMID: 27323830 Ref: Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis. PMID: 27460659 Ref: A Novel Malate Dehydrogenase 2 Inhibitor Suppresses Hypoxia-Inducible Factor-1 by Regulating Mitochondrial Respiration. PMID: 27611801 Ref: Fluorescent 6-amino-6-deoxyglycoconjugates for glucose transporter mediated bioimaging. PMID: 27765631 Ref: hERG1 positivity and Glut-1 negativity identifies high-risk TNM stage I and II colorectal cancer patients, regardless of adjuvant chemotherapy. PMID: 27789963 Ref: Hypoxic resistance of KRAS mutant tumor cells to 3-Bromopyruvate is counteracted by Prima-1 and reversed by N-acetylcysteine. PMID: 27863474 |
Ref: Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer. PMID: 26927284 Ref: Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. PMID: 27922662 Ref: Elevated expression of TrpC5 and GLUT1 is associated with chemoresistance in colorectal cancer. PMID: 28000878 Ref: GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer. PMID: 28052033 Ref: Predictive value of glucose transporter-1 and glucose transporter-3 for survival of cancer patients: A meta-analysis. PMID: 28086215 Ref: [Expression of hypoxia-inducible factor 1alpha, glucose transporter 1 and lactate dehydrogenase 5 in colorectal cancer and clinicopathologic significance]. PMID: 28173667 Ref: Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. PMID: 28230866 Ref: Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. PMID: 28423551 Ref: Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors. PMID: 28445144 Ref: PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism. PMID: 28791350 Ref: Gender-related prognostic significance of clinical and biological tumor features in rectal cancer patients receiving short-course preoperative radiotherapy. PMID: 28794690 Ref: Role of glucose metabolism related gene GLUT1 in the occurrence and prognosis of colorectal cancer. PMID: 28915636 Ref: Morin Inhibits Proliferation of SW480 Colorectal Cancer Cells by Inducing Apoptosis Mediated by Reactive Oxygen Species Formation and Uncoupling of Warburg Effect. PMID: 28955240 Ref: SODD promotes glucose uptake of colorectal cancer cells via AKT pathway. PMID: 29087604 Ref: Validity and clinical impact of glucose transporter 1 expression in colorectal cancer. PMID: 29205188 |
Ref: Effects of Glut1 gene silencing on proliferation, differentiation, and apoptosis of colorectal cancer cells by targeting the TGF-beta/PI3K-AKT-mTOR signaling pathway. PMID: 28884839 Ref: Role of JMJD2B in colon cancer cell survival under glucose-deprived conditions and the underlying mechanisms. PMID: 28945223 Ref: Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells. PMID: 29301589 Ref: miR-328 mediates a metabolic shift in colon cancer cells by targeting SLC2A1/GLUT1. PMID: 29374351 Ref: Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer. PMID: 29463225 Ref: Berberine decelerates glucose metabolism via suppression of mTORdependent HIF1alpha protein synthesis in colon cancer cells. PMID: 29565467 Ref: Chemokine (C-X-C motif) ligand 1 is associated with tumor progression and poor prognosis in patients with colorectal cancer. PMID: 29784873 Ref: Yin Yang 1 promotes the Warburg effect and tumorigenesis via glucose transporter GLUT3. PMID: 29869834 Ref: Genome wide DNA differential methylation regions in colorectal cancer patients in relation to blood related family members, obese and non-obese controls - a preliminary report. PMID: 29876008 Ref: Targeting glucose transport and the NAD pathway in tumor cells with STF-31: a re-evaluation. PMID: 29949049 Ref: PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma. PMID: 30172011 |