Primary Site >> Colorectal Cancer
Gene >> SIRT1
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Ref: Male cancer incidence by occupation: New Zealand, 1972-1984. PMID: 8666482 |
Ref: Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PMID: 16596166 Ref: Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism. PMID: 16849586 |
Ref: Function of the SIRT1 protein deacetylase in cancer. PMID: 17806102 |
Ref: HDACs and HDAC inhibitors in colon cancer. PMID: 18326939 Ref: The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PMID: 18414679 Ref: miR-34a repression of SIRT1 regulates apoptosis. PMID: 18755897 |
Ref: Expression and prognostic significance of SIRT1 in ovarian epithelial tumours. PMID: 19404850 Ref: Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate. PMID: 19413317 Ref: SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 19430421 Ref: SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. PMID: 19433578 Ref: Identification of a cell-active non-peptide sirtuin inhibitor containing N-thioacetyl lysine. PMID: 19700324 Ref: Role of prosurvival molecules in the action of lidamycin toward human tumor cells. PMID: 19725468 |
Ref: Epigenetic modifications induced by RGC-32 in colon cancer. PMID: 19883641 Ref: p53 Regulates LIF expression in human medulloblastoma cells. PMID: 19907922 |
Ref: Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells. PMID: 21067862 Ref: Loss of a single Hic1 allele accelerates polyp formation in Apc(Delta716) mice. PMID: 21297660 |
Ref: SIRT1 and the clock gene machinery in colorectal cancer. PMID: 22149272 Ref: The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. PMID: 22190494 Ref: MicroRNA Regulation of SIRT1. PMID: 22479251 Ref: SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of beta-catenin. PMID: 22640743 Ref: Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors. PMID: 22642300 Ref: Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells. PMID: 22931526 Ref: Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. PMID: 23045412 Ref: Expression profiling of archival tumors for long-term health studies. PMID: 23136189 Ref: Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells. PMID: 23189967 |
Ref: Anti-cancer effects of naturally occurring compounds through modulation of signal transduction and miRNA expression in human colon cancer cells. PMID: 23954321 Ref: SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer. PMID: 24009628 Ref: Amurensin G enhances the susceptibility to tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity of cancer stem-like cells of HCT-15 cells. PMID: 24118446 Ref: [c-MYC-mediated regulations in colorectal cancer]. PMID: 24196628 Ref: The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-fluorouracil and oxaliplatin in colon cancer cells. PMID: 24512730 |
Ref: Clinicopathological significance of SIRT1 expression in colorectal adenocarcinoma. PMID: 24816737 Ref: [Effect of hydrogen sulfide on human colon cancer SW480 cell proliferation and migration in vitro]. PMID: 24849440 Ref: Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer. PMID: 24890145 Ref: Ubiquitin-specific peptidase USP22 negatively regulates the STAT signaling pathway by deubiquitinating SIRT1. PMID: 24969755 Ref: Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PMID: 25013930 Ref: Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells. PMID: 25199460 Ref: High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients. PMID: 25500546 Ref: Fentanyl increases colorectal carcinoma cell apoptosis by inhibition of NF-kappaB in a Sirt1-dependent manner. PMID: 25520062 |
Ref: Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer. PMID: 25307864 Ref: A novel pyrido-thieno-pyrimidine derivative activates p53 through induction of phosphorylation and acetylation in colorectal cancer cells. PMID: 25338966 Ref: Immunohistochemical Characterization of Large Intestinal Adenocarcinoma in the Rhesus Macaque (Macaca mulatta). PMID: 25367367 Ref: MiR-34a inhibits migration and invasion by regulating the SIRT1/p53 pathway in human SW480 cells. PMID: 25585539 Ref: UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of beta-lapachone in human colon cancer cells. PMID: 25692465 Ref: The membrane protein melanoma cell adhesion molecule (MCAM) is a novel tumor marker that stimulates tumorigenesis in hepatocellular carcinoma. PMID: 25728681 Ref: SIRT1/PGC1alpha-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer. PMID: 25779952 Ref: The expression and correlation of SIRT1 and Phospho-SIRT1 in colorectal cancer. PMID: 25785061 Ref: Annexin A4 and cancer. PMID: 26048190 Ref: Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells. PMID: 26219912 Ref: Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials. PMID: 26227583 Ref: Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1. PMID: 26363315 Ref: The role of microRNAs in the resistance to colorectal cancer treatments. PMID: 26518892 |
Ref: Positive regulation of beta-catenin-PROX1 signaling axis by DBC1 in colon cancer progression. PMID: 26477307 Ref: Clinicopathological significance of SIRT1 expression in colorectal cancer: A systematic review and meta analysis. PMID: 26763348 Ref: Expression and clinical significance of Sirt1 in colorectal cancer. PMID: 26893713 Ref: Sirt1 Is Required for Resveratrol-Mediated Chemopreventive Effects in Colorectal Cancer Cells. PMID: 26959057 Ref: SIRT1 promotes epithelial-mesenchymal transition and metastasis in colorectal cancer by regulating Fra-1 expression. PMID: 26975631 Ref: Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer. PMID: 26986234 Ref: Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4beta-hydroxywithanolide E isolated from Physalis peruviana. PMID: 27006100 Ref: SIRT1 prevents hyperuricemia via the PGC-1alpha/PPARgamma-ABCG2 pathway. PMID: 27022940 Ref: Expression patterns of sirtuin 1-AMPK-autophagy pathway in chronic colitis and inflammation-associated colon neoplasia in IL-10-deficient mice. PMID: 27085036 Ref: Downregulation of miR-199b is associated with distant metastasis in colorectal cancer via activation of SIRT1 and inhibition of CREB/KISS1 signaling. PMID: 27145368 Ref: Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review. PMID: 27470380 Ref: Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures. PMID: 27865348 Ref: Role of diets rich in omega-3 and omega-6 in the development of cancer. PMID: 29421289 |
Ref: Haploinsufficiency of SIRT1 Enhances Glutamine Metabolism and Promotes Cancer Development. PMID: 28162896 Ref: Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway. PMID: 28182012 Ref: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. PMID: 28197625 Ref: Effect of sodium salt of Butrin, a novel compound isolated from Butea monosperma flowers on suppressing the expression of SIRT1 and Aurora B kinase-mediated apoptosis in colorectal cancer cells. PMID: 28390310 Ref: Kallistatin suppresses cancer development by multi-factorial actions. PMID: 28427524 Ref: Energy sensing pathways: Bridging type 2 diabetes and colorectal cancer? PMID: 28465145 Ref: A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. PMID: 28526414 Ref: Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? PMID: 28799785 Ref: Acetylation of hMOF Modulates H4K16ac to Regulate DNA Repair Genes in Response to Oxidative Stress. PMID: 28808424 Ref: Toxicarioside O induces protective autophagy in a sirtuin-1-dependent manner in colorectal cancer cells. PMID: 28881770 Ref: SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. PMID: 28923398 Ref: Long non-coding RNA HNF1A-AS1 mediated repression of miR-34a/SIRT1/p53 feedback loop promotes the metastatic progression of colon cancer by functioning as a competing endogenous RNA. PMID: 28943452 Ref: Resveratrol Regulates Colorectal Cancer Cell Invasion by Modulation of Focal Adhesion Molecules. PMID: 28953264 Ref: Therapeutic strategies against cancer stem cells in human colorectal cancer. PMID: 29250169 Ref: Intratumoral heterogeneity for inactivating frameshift mutation of CUX1 and SIRT1 genes in gastric and colorectal cancers. PMID: 29363918 |
Ref: NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling. PMID: 29203250 Ref: NAMPT Is a Potent Oncogene in Colon Cancer Progression that Modulates Cancer Stem Cell Properties and Resistance to Therapy through Sirt1 and PARP. PMID: 29203587 Ref: Autophagic flux is essential for the downregulation of D-dopachrome tautomerase by atractylenolide I to ameliorate intestinal adenoma formation. PMID: 29368299 Ref: Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis. PMID: 29427626 Ref: Polyphenol extracts from dried sugarcane inhibit inflammatory mediators in an in vitro colon cancer model. PMID: 29432917 Ref: miR-34a increases the sensitivity of colorectal cancer cells to 5-fluorouracil in vitro and in vivo. PMID: 29511598 Ref: MiR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1. PMID: 29552311 Ref: Role of microRNAs in the resistance of colorectal cancer to chemoradiotherapy. PMID: 29556386 Ref: SIRT1 in Colorectal Cancer: A Friend or Foe? PMID: 29584552 Ref: The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. PMID: 29644357 Ref: Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1. PMID: 29807115 Ref: The pluripotency network in colorectal cancer pathogenesis and prognosis: an update. PMID: 29944017 Ref: Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy. PMID: 30016968 Ref: Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells. PMID: 30029680 Ref: The clinicopathological significance of SIRT1 expression in colon cancer: An immunohistochemical study and meta-analysis. PMID: 30082156 Ref: Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. PMID: 30191976 Ref: RARbeta acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells. PMID: 30252536 Ref: miR-128 Targets the SIRT1/ROS/DR5 Pathway to Sensitize Colorectal Cancer to TRAIL-Induced Apoptosis. PMID: 30257253 Ref: Long non-coding RNA NEAT1 promotes colorectal cancer progression by competitively binding miR-34a with SIRT1 and enhancing the Wnt/beta-catenin signaling pathway. PMID: 30312725 Ref: SIRT1 in Secretory Organ Cancer. PMID: 30319549 |