Primary Site >> Stomach Cancer
Gene >> SHH
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Ref: Transcription of sonic hedgehog, a potential factor for gastric morphogenesis and gastric mucosa maintenance, is up-regulated in acidic conditions. PMID: 14691301 |
Ref: KIF27 is one of orthologs for Drosophila Costal-2. PMID: 15547729 Ref: Characterization of KIF7 gene in silico. PMID: 15547730 |
Ref: Identification and characterization of rat Desert hedgehog and Indian hedgehog genes in silico. PMID: 15645142 Ref: Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. PMID: 15743355 Ref: Hedgehog signaling pathway and gastric cancer. PMID: 16258256 Ref: p53-Independent negative regulation of p21/cyclin-dependent kinase-interacting protein 1 by the sonic hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma cells. PMID: 16322228 |
Ref: Increased expression of sonic hedgehog and altered methylation of its promoter region in gastric cancer and its related lesions. PMID: 16528374 Ref: Study of Sonic hedgehog signaling pathway related molecules in gastric carcinoma. PMID: 16810741 Ref: Hedgehog signal activation in gastric pit cell and in diffuse-type gastric cancer. PMID: 16831586 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 |
Ref: Sonic hedgehog expression in gastric cancer and gastric adenoma. PMID: 17390043 Ref: De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis. PMID: 17505514 Ref: Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia. PMID: 17520681 Ref: Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancer. PMID: 17568183 Ref: Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer. PMID: 17724792 |
Ref: Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. PMID: 18174246 Ref: Sonic hedgehog is associated with H+-K+-ATPase-containing membranes in gastric parietal cells and secreted with histamine stimulation. PMID: 18483183 Ref: Sonic hedgehog and CDX2 expression in the stomach. PMID: 19120891 |
Ref: Sonic hedgehog in gastric physiology and neoplastic transformation: friend or foe? PMID: 19104239 Ref: Regulation of the hedgehog signaling by the mitogen-activated protein kinase cascade in gastric cancer. PMID: 19142899 Ref: Genome-wide analysis of histone H3 lysine 27 trimethylation by ChIP-chip in gastric cancer patients. PMID: 19267258 Ref: Transcriptional regulation of WNT2B based on the balance of Hedgehog, Notch, BMP and WNT signals. PMID: 19360354 Ref: Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. PMID: 19860666 Ref: [Hedgehog signaling pathway activates in gastric carcinoma and promotes the proliferation through GLI1 in MKN28 cell]. PMID: 19921574 |
Ref: Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis. PMID: 19540662 Ref: Contrasting activity of Hedgehog and Wnt pathways according to gastric cancer cell differentiation: relevance of crosstalk mechanisms. PMID: 19930158 Ref: Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. PMID: 20087349 Ref: Direct repression of Sonic Hedgehog expression in the stomach by Cdx2 leads to intestinal transformation. PMID: 20199401 Ref: Effect of Helicobacter pylori infection on the sonic hedgehog signaling pathway in gastric cancer cells. PMID: 20428805 Ref: The role of sonic hedgehog reemergence during gastric cancer. PMID: 20437100 |
Ref: Cross-signaling among phosphinositide-3 kinase, mitogen-activated protein kinase and sonic hedgehog pathways exists in esophageal cancer. PMID: 20839260 Ref: Sonic hedgehog pathway is essential for maintenance of cancer stem-like cells in human gastric cancer. PMID: 21394208 Ref: Identification of CD44+CD24+ gastric cancer stem cells. PMID: 21882047 Ref: Sonic hedgehog pathway promotes metastasis and lymphangiogenesis via activation of Akt, EMT, and MMP-9 pathway in gastric cancer. PMID: 21975935 Ref: Role of Sonic Hedgehog signaling during progression from inflammation to cancer in the stomach. PMID: 22180844 Ref: The Hedgehog signalling pathway and its prognostic impact in human gliomas. PMID: 22295347 |
Ref: Eradication of H. pylori did not improve abnormal sonic hedgehog expression in the high risk group for gastric cancer. PMID: 21953141 Ref: The role of Sonic Hedgehog as a regulator of gastric function and differentiation. PMID: 22391317 Ref: Activation of the sonic hedgehog pathway and its prognostic impact in patients with gastric cancer. PMID: 22456124 Ref: ZIC1 modulates cell-cycle distributions and cell migration through regulation of sonic hedgehog, PI(3)K and MAPK signaling pathways in gastric cancer. PMID: 22799764 Ref: Prognostic value of sonic hedgehog protein expression in gastric cancer. PMID: 22941587 Ref: Stem cells, self-renewal and cancer of the gastric epithelium. PMID: 22963573 Ref: Inflammation and Gli2 suppress gastrin gene expression in a murine model of antral hyperplasia. PMID: 23110168 |
Ref: Aldehyde dehydrogenase high gastric cancer stem cells are resistant to chemotherapy. PMID: 23440340 Ref: Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PMID: 23520544 Ref: Suppression of growth and migration by blocking the Hedgehog signaling pathway in gastric cancer cells. PMID: 24027019 Ref: Sonic hedgehog mediates the proliferation and recruitment of transformed mesenchymal stem cells to the stomach. PMID: 24069395 |
Ref: Expression level of sonic hedgehog correlated with the speed of gastric mucosa regeneration in artificial gastric ulcers. PMID: 24224878 Ref: Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1. PMID: 24297371 Ref: Characterization of sonic hedgehog inhibition in gastric carcinoma cells. PMID: 24765141 Ref: Mesenchymal stem cells induce epithelial proliferation within the inflamed stomach. PMID: 24789207 Ref: Sonic hedgehog pathway contributes to gastric cancer cell growth and proliferation. PMID: 24804165 Ref: Clinicopathological correlation and prognostic significance of sonic hedgehog protein overexpression in human gastric cancer. PMID: 25197388 |
Ref: Interaction of sonic hedgehog (SHH) pathway with cancer stem cell genes in gastric cancer. PMID: 25636508 Ref: Hedgehog pathway aberrations and gastric cancer; evaluation of prognostic impact and exploration of therapeutic potentials. PMID: 25680409 Ref: Molecular biomarkers in gastric cancer. PMID: 26052595 Ref: Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44(+)/Musashi-1(+) gastric cancer stem cells. PMID: 26276718 Ref: Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process. PMID: 26819804 |
Ref: Reduced proliferation and increased apoptosis of the SGC7901 gastric cancer cell line on exposure to GDC0449. PMID: 26676867 Ref: CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection. PMID: 26839535 Ref: Autocrine Sonic hedgehog signaling promotes gastric cancer proliferation through induction of phospholipase Cgamma1 and the ERK1/2 pathway. PMID: 27039174 Ref: High extracellular pressure promotes gastric cancer cell adhesion, invasion, migration and suppresses gastric cancer cell differentiation. PMID: 27278077 |
Ref: Metformin suppresses the expression of Sonic hedgehog in gastric cancer cells. PMID: 28260041 Ref: Hedgehog Signaling Links Chronic Inflammation to Gastric Cancer Precursor Lesions. PMID: 28275687 Ref: Distinct Involvement of the Sonic Hedgehog Signaling Pathway in Gastric Adenocarcinoma of Fundic Gland Type and Conventional Gastric Adenocarcinoma. PMID: 28738329 Ref: Exosomes Derived from Human Bone Marrow Mesenchymal Stem Cells Promote Tumor Growth Through Hedgehog Signaling Pathway. PMID: 28817816 |
Ref: Combination of TNM staging and pathway based risk score models in patients with gastric cancer. PMID: 29231991 Ref: Gastric cancer and Hedgehog signaling pathway: emerging new paradigms. PMID: 29725500 |