Primary Site >> Colorectal Cancer
Gene >> SFRP1
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Ref: A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. PMID: 11992124 |
Ref: [Molecular changes in development and progression of urothelial carcinoma]. PMID: 16888910 |
Ref: The Wnt antagonist sFRP1 in colorectal tumorigenesis. PMID: 14871816 Ref: Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors. PMID: 15289865 Ref: Methylation-associated silencing of the Wnt antagonist SFRP1 gene in human ovarian cancers. PMID: 15471560 Ref: Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. PMID: 15526363 Ref: An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. PMID: 15542433 |
Ref: Comparative genomics on SFRP1 orthologs. PMID: 16077939 Ref: Comparative genomics on SFRP2 orthologs. PMID: 16077992 Ref: Mutant KRAS in aberrant crypt foci (ACF): initiation of colorectal cancer? PMID: 16219426 |
Ref: WNT antagonist, SFRP1, is Hedgehog signaling target. PMID: 16328026 Ref: Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. PMID: 16491118 Ref: The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas. PMID: 16523202 Ref: Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). PMID: 17089004 Ref: Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor. PMID: 17131472 |
Ref: Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. PMID: 17297461 Ref: Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. PMID: 17408633 Ref: Turning the tables: Myc activates Wnt in breast cancer. PMID: 17726380 Ref: DNA stool test for colorectal cancer: hypermethylation of the secreted frizzled-related protein-1 gene. PMID: 17762966 Ref: [The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor]. PMID: 17923031 Ref: [Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor]. PMID: 18396643 |
Ref: Distinct expression pattern of the full set of secreted phospholipases A2 in human colorectal adenocarcinomas: sPLA2-III as a biomarker candidate. PMID: 18212756 Ref: Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa. PMID: 18542073 Ref: Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. PMID: 18716850 Ref: Silencing of secreted frizzled-related protein genes in MSI colorectal carcinogenesis. PMID: 18795670 |
Ref: Gene-specific methylation: potential markers for colorectal cancer. PMID: 19404924 Ref: Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling. PMID: 19454286 |
Ref: SFRP4 was overexpressed in colorectal carcinoma. PMID: 19730886 Ref: Aberrant gene promoter methylation associated with sporadic multiple colorectal cancer. PMID: 20098741 Ref: Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers. PMID: 20131317 Ref: PTCH1, a receptor of Hedgehog signaling pathway, is correlated with metastatic potential of colorectal cancer. PMID: 20230186 Ref: Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. PMID: 20395289 |
Ref: Blocking Wnt signaling by SFRP-like molecules inhibits in vivo cell proliferation and tumor growth in cells carrying active beta-catenin. PMID: 20856206 Ref: Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. PMID: 21304055 Ref: DNA methylation predicts recurrence from resected stage III proximal colon cancer. PMID: 21509761 |
Ref: Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis. PMID: 22703586 Ref: [Multi-gene methylation detection increases positive methylation rate in colorectal cancer]. PMID: 22736139 Ref: Methylation of the polycomb group target genes is a possible biomarker for favorable prognosis in colorectal cancer. PMID: 23010642 Ref: Methylation pattern of SFRP1 promoter in stool sample is a potential marker for early detection of colorectal cancer. PMID: 23946935 |
Ref: Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/beta-catenin signalling and reduces colon pre-neoplasia in rats. PMID: 22716201 Ref: Promoter hypermethylation of the tumor-suppressor genes ITIH5, DKK3, and RASSF1A as novel biomarkers for blood-based breast cancer screening. PMID: 23320751 Ref: Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling. PMID: 23376422 Ref: DNA hypermethylation of a selective gene panel as a risk marker for colon cancer in patients with ulcerative colitis. PMID: 23546389 Ref: Toward a comprehensive and systematic methylome signature in colorectal cancers. PMID: 23975090 Ref: The prognostic significance of WNT pathway in surgically-treated colorectal cancer: beta-catenin expression predicts for disease-free survival. PMID: 24123033 Ref: Black raspberries protectively regulate methylation of Wnt pathway genes in precancerous colon tissue. PMID: 24129635 |
Ref: [Detection of RASSF2 and sFRP1 promoter region methylation in sporadic colorectal cancer patients]. PMID: 24519048 Ref: A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene. PMID: 24876104 Ref: Aberrant promoter methylation of the SFRP1 gene may contribute to colorectal carcinogenesis: a meta-analysis. PMID: 24929326 Ref: Coexpression of SFRP1 and WIF1 as a prognostic predictor of favorable outcomes in patients with colorectal carcinoma. PMID: 24949429 Ref: Distinct molecular features of different macroscopic subtypes of colorectal neoplasms. PMID: 25093594 Ref: Analysis of DNA methylation in bowel lavage fluid for detection of colorectal cancer. PMID: 25139296 Ref: [Expression of secreted frizzled related protein 1, beta-catenin and E-cadherin in colorectal carcinoma and its clinicopathological significances]. PMID: 25187453 Ref: Myofibroblast-derived SFRP1 as potential inhibitor of colorectal carcinoma field effect. PMID: 25405986 Ref: Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists. PMID: 25432628 Ref: In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers. PMID: 25705155 |
Ref: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. PMID: 24948044 Ref: Comparison of Automated and Manual DNA Isolation Methods for DNA Methylation Analysis of Biopsy, Fresh Frozen, and Formalin-Fixed, Paraffin-Embedded Colorectal Cancer Samples. PMID: 25576093 Ref: DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas. PMID: 26203307 Ref: Patterns of somatic uniparental disomy identify novel tumor suppressor genes in colorectal cancer. PMID: 26243311 Ref: Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas. PMID: 26291085 Ref: Phytochemical Indicaxanthin Inhibits Colon Cancer Cell Growth and Affects the DNA Methylation Status by Influencing Epigenetically Modifying Enzyme Expression and Activity. PMID: 26439130 Ref: Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by activating Wnt/beta-catenin signalling. PMID: 26468775 Ref: DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer. PMID: 26482433 Ref: Acquired resistance to decitabine and cross-resistance to gemcitabine during the long-term treatment of human HCT116 colorectal cancer cells with decitabine. PMID: 26622566 Ref: [T Cell Factor 4, beta-catenin and SFRP1 Expression of Wnt Signaling Pathway in Colorectal Carcinoma and the Prognosis]. PMID: 26710459 |
Ref: Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma. PMID: 26756304 Ref: Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer. PMID: 27245242 Ref: Methylation of SFRP2 gene as a promising noninvasive biomarker using feces in colorectal cancer diagnosis: a systematic meta-analysis. PMID: 27659069 Ref: MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition. PMID: 27668319 Ref: Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma. PMID: 28058013 |
Ref: Diagnostic and prognostic role of cell-free DNA testing for colorectal cancer patients. PMID: 27943272 Ref: Effects of supplementation with nondigestible carbohydrates on fecal calprotectin and on epigenetic regulation of SFRP1 expression in the large-bowel mucosa of healthy individuals. PMID: 28077379 Ref: DNA methylation assay for colorectal carcinoma. PMID: 28443202 Ref: Analysis of the DNA methylation level of cancer-related genes in colorectal cancer and the surrounding normal mucosa. PMID: 28533824 Ref: Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer. PMID: 28540987 Ref: Extracellular inhibitors can attenuate tumorigenic Wnt pathway activity in adenomatous polyposis coli mutants: Predictions of a validated mathematical model. PMID: 28708837 Ref: Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples. PMID: 28753106 Ref: MicroRNA-27a Promotes the Proliferation and Invasiveness of Colon Cancer Cells by Targeting SFRP1 through the Wnt/beta-Catenin Signaling Pathway. PMID: 28772260 Ref: A transcriptome-based protein network that identifies new therapeutic targets in colorectal cancer. PMID: 28962550 |
Ref: Blood Collection and Cell-Free DNA Isolation Methods Influence the Sensitivity of Liquid Biopsy Analysis for Colorectal Cancer Detection. PMID: 29374860 Ref: Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors. PMID: 29524208 Ref: Inhibition of DNMT suppresses the stemness of colorectal cancer cells through down-regulating Wnt signaling pathway. PMID: 29601907 Ref: Effects of secreted frizzled-related protein 1 on proliferation, migration, invasion, and apoptosis of colorectal cancer cells. PMID: 29610564 Ref: The importance of stool DNA methylation in colorectal cancer diagnosis: A meta-analysis. PMID: 30024936 Ref: Hypermethylated Promoters of Secreted Frizzled-Related Protein Genes are Associated with Colorectal Cancer. PMID: 30368728 |