Primary Site >> Colorectal Cancer
Gene >> SESN2
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Ref: The inhibition of autophagy sensitises colon cancer cells with wild-type p53 but not mutant p53 to topotecan treatment. PMID: 23024792 |
Ref: Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells. PMID: 25337554 |
Ref: Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner. PMID: 24535669 |
Ref: Decreased expression of sestrin 2 predicts unfavorable outcome in colorectal cancer. PMID: 25572852 |
Ref: Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. PMID: 26913956 Ref: Sestrin2 inhibits hypoxia-inducible factor-1alpha accumulation via AMPK-mediated prolyl hydroxylase regulation. PMID: 27840318 |
Ref: 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. PMID: 28028695 |
Ref: Novel evidence for a PIWI-interacting RNA (piRNA) as an oncogenic mediator of disease progression, and a potential prognostic biomarker in colorectal cancer. PMID: 29382334 |