Primary Site >> Colorectal Cancer
Gene >> SERPINE1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Plasminogen activators and plasminogen activator inhibitor in malignant and non-malignant ascitic fluid. PMID: 2852112 |
Ref: Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells. PMID: 2169614 Ref: Insensitivity of laminin degradation directed by receptor bound urokinase to PAI-1 in cultured colon cancer. PMID: 2390419 |
Ref: Correlation between urokinase-type plasminogen activator production and the metastatic ability of human rectal cancer cells. PMID: 1765431 Ref: Plasminogen activator inhibitor in stomach and colorectal carcinomas. PMID: 1796298 Ref: The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma. PMID: 1855221 Ref: Plasminogen activator inhibitor 1 in human carcinoma tissues. PMID: 1904404 |
Ref: Antitumor effects of B3-PE and B3-LysPE40 in a nude mouse model of human breast cancer and the evaluation of B3-PE toxicity in monkeys. PMID: 1591729 |
Ref: Sodium butyrate differentially modulates plasminogen activator inhibitor type-1, urokinase plasminogen activator, and its receptor in a human colon carcinoma cell. PMID: 8102211 Ref: Evaluation of the coagulation/fibrinolysis balance in patients with colorectal cancer. PMID: 8276320 Ref: The role of the urokinase receptor in extracellular matrix degradation by HT29 human colon carcinoma cells. PMID: 8381394 Ref: Plasminogen activators and plasminogen activator inhibitors in human colorectal carcinoma tissues are not expressed by the tumour cells. PMID: 8518031 |
Ref: Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro. PMID: 7518782 Ref: Expression and release of plasminogen activators, their inhibitors and receptor by human tumor cell lines. PMID: 7872665 Ref: Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator. PMID: 7962113 Ref: Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer. PMID: 8033138 Ref: Expression of plasminogen activator inhibitor type 1 (PAI-1) by HT-29di human large bowel carcinoma cells is modulated as a function of epithelial differentiation. PMID: 8149346 |
Ref: The urokinase/urokinase-receptor system and cancer invasion. PMID: 7549068 Ref: Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness. PMID: 7557947 Ref: Butyrate regulates gene expression of the plasminogen activating system in colon cancer cells. PMID: 7665235 Ref: Localization of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, 2 and plasminogen in colon cancer. PMID: 7737909 Ref: Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. PMID: 8587011 Ref: Blood and tissue fibrinolytic profiles in patients with colorectal carcinoma. PMID: 8788547 |
Ref: Fibrinolysis components as prognostic markers in breast cancer and colorectal carcinoma. PMID: 8694536 Ref: Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. PMID: 8826848 Ref: Expression of tissue-type plasminogen activator, plasminogen activator inhibitor and von Willebrand factor in the supernatant of endothelial cell cultures in response to the seeding of adenocarcinoma cell line HRT-18. PMID: 8952858 Ref: Cytokines may influence tumor growth and spread. An in vitro study in two human cancer cell lines. PMID: 9007614 |
Ref: High level of urokinase-type plasminogen activator is a new prognostic marker in patients with gastric carcinoma. PMID: 9041148 Ref: Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer. PMID: 9192984 |
Ref: Association between plasma concentrations of plasminogen activator inhibitor-1 and survival in patients with colorectal cancer. PMID: 9549453 Ref: [Percutaneous ethanol and acetic acid injection for liver metastasis from colon cancer--two case reports]. PMID: 9571976 Ref: Involvement of vascular endothelial growth factor and urokinase-type plasminogen activator receptor in microvessel invasion in human colorectal cancers. PMID: 9583734 Ref: Association between plasma plasminogen activator inhibitor-1 and survival in colorectal cancer. Measuring C reactive protein concentrations may be more useful. PMID: 9732351 |
Ref: DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. PMID: 10340387 Ref: [Assay and detection methods for urokinase-type plasminogen activator and its related-factors]. PMID: 10396332 Ref: [The role of cathepsins and the plasminogen activator/inhibitor system in colorectal cancer]. PMID: 10489782 Ref: The role of cysteine and serine proteases in colorectal carcinoma. PMID: 10506696 Ref: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 as a prognostic factor in human colorectal carcinomas. PMID: 10521987 Ref: Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlates well with tumor size. PMID: 10594855 |
Ref: Mechanical deformation induces proliferation of human colorectal carcinoma cells. PMID: 10675497 Ref: Angiostatin generation by human tumor cell lines: involvement of plasminogen activators. PMID: 10842188 Ref: Preoperative plasma plasminogen activator inhibitor type-1 and serum C-reactive protein levels in patients with colorectal cancer. The RANX05 Colorectal Cancer Study Group. PMID: 11005561 Ref: Urokinase-type plasminogen activator and its receptor in colorectal cancer: independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. PMID: 11008205 Ref: Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression. PMID: 11193049 |
Ref: Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer. PMID: 11376560 Ref: Plasminogen activator inhibitor 1 (PAI-1) levels and gene promoter polymorphisms in subjects with colorectal cancer. PMID: 11484982 Ref: Hemostatic alterations in patients with benign and malignant colorectal disease during major abdominal surgery. PMID: 11738072 Ref: Coagulative system activation and fibrinolytic system inhibition activities arise from tumoral draining vein in colon carcinoma. PMID: 11755952 |
Ref: High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer. PMID: 11774293 Ref: Prediction of distant metastases after curative surgery for rectal cancer. PMID: 11855920 Ref: Plasmin/plasminogen system in colorectal cancer. PMID: 11965442 Ref: Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas. PMID: 12218297 Ref: Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. PMID: 12405290 Ref: Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA. PMID: 12529016 Ref: [Comparative analysis of metastatic variants from the colorectal tumor cell line HT-29] PMID: 12601885 Ref: Bacterial antigen-induced release of white cell- and platelet-derived bioactive substances in vitro. PMID: 12622428 |
Ref: Prospective randomized trial to determine the influence of laparoscopic and conventional colorectal resection on intravasal fibrinolytic capacity. PMID: 12364991 Ref: Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis. PMID: 12490312 Ref: Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer. PMID: 12619063 Ref: The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. PMID: 12706368 Ref: Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors. PMID: 12720300 Ref: Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer. PMID: 12833173 Ref: Correlation between metastatic potential and variants from colorectal tumor cell line HT-29. PMID: 14606113 |
Ref: Leading-edge myofibroblasts in human colon cancer express plasminogen activator inhibitor-1. PMID: 15323143 Ref: NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. PMID: 15325613 |
Ref: Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer. PMID: 16088182 Ref: Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer. PMID: 16091756 |
Ref: Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. PMID: 16462766 Ref: Dietary fiber enhances a tumor suppressor signaling pathway in the gut. PMID: 16632996 Ref: Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. PMID: 16916471 Ref: PAI-1 expression levels in esophageal and colorectal cancers are closely correlated to those in corresponding normal tissues. PMID: 17201153 |
Ref: Different matrix micro-environments in colon cancer and diverticular disease. PMID: 17021746 Ref: Clinical implications of matrix metalloproteinase-1, -3, -7, -9, -12, and plasminogen activator inhibitor-1 gene polymorphisms in colorectal cancer. PMID: 17608852 Ref: Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer. PMID: 17804466 Ref: High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. PMID: 17997817 |
Ref: The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients. PMID: 18193223 Ref: Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. PMID: 18258607 Ref: Intraperitoneal infusion of recombinant plasminogen activator inhibitor type 2 induced apoptosis in implanted human colon cancer and inhibited its growth and liver metastasis. PMID: 18507009 Ref: Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. PMID: 18616803 Ref: Oncogenic Ras and transforming growth factor-beta synergistically regulate AU-rich element-containing mRNAs during epithelial to mesenchymal transition. PMID: 18644977 Ref: A personalized approach to cancer treatment: how biomarkers can help. PMID: 18801934 |
Ref: uPA and PAI-1 in rectal cancer--relationship to radiotherapy and clinical outcome. PMID: 18533186 Ref: Studies of TGF-beta(1-3) in serosal fluid during abdominal surgery and their effect on in vitro human mesothelial cell proliferation. PMID: 19062040 Ref: Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. PMID: 19123477 Ref: Focused PCR screen reveals p53 dependence of nitric oxide-induced apoptosis and up-regulation of maspin and plasminogen activator inhibitor-1 in tumor cells. PMID: 19147537 Ref: Active TGF-beta1 correlates with myofibroblasts and malignancy in the colorectal adenoma-carcinoma sequence. PMID: 19462508 Ref: Differential prognostic impact of uPA and PAI-1 in colon and rectal cancer. PMID: 19776673 |
Ref: Plasma concentrations of VCAM-1 and PAI-1: a predictive biomarker for post-operative recurrence in colorectal cancer. PMID: 20491774 Ref: Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer. PMID: 20740581 Ref: [Clinical improvement of membranous nephropathy after a resection of rectal cancer]. PMID: 21224656 |
Ref: beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells. PMID: 20473943 Ref: The plasminogen activator inhibitor system in colon cancer cell lines is influenced by the CO2 pneumoperitoneum. PMID: 20931209 Ref: Loss of adiponectin promotes intestinal carcinogenesis in Min and wild-type mice. PMID: 21334339 Ref: D-dimer, plasminogen activator inhibitor-1, prothrombin fragments and protein C - role in prothrombotic state of colorectal cancer. PMID: 21391740 Ref: Clotting factor gene polymorphisms and colorectal cancer risk. PMID: 21422408 Ref: Renin-angiotensin system inhibitors suppress azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. PMID: 21640075 Ref: Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. PMID: 21744990 Ref: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. PMID: 21859479 Ref: Malignant tumours of colon and rectum from the blood clotting view. PMID: 22180990 Ref: Clinical relevance of uPA, uPAR, PAI 1 and PAI 2 tissue expression and plasma PAI 1 level in colorectal carcinoma patients. PMID: 22234062 |
Ref: ARNTL2 and SERPINE1: potential biomarkers for tumor aggressiveness in colorectal cancer. PMID: 22198637 Ref: Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling. PMID: 22363817 Ref: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. PMID: 22377968 Ref: mRNA expression of adipocytokines and glucocorticoid-related genes are associated with downregulation of E-cadherin mRNA in colorectal adenocarcinomas. PMID: 22411584 Ref: Adipokines linking obesity with colorectal cancer risk in postmenopausal women. PMID: 22511581 Ref: Role of plasminogen activator inhibitor-1 in urokinase's paradoxical in vivo tumor suppressing or promoting effects. PMID: 22912336 Ref: [Impact of laparoscopic colorectal surgery on the peritoneal microstructural injury and expression of t-PA/PAI-1]. PMID: 22941690 Ref: Perioperative PAI-1 values in surgically treated colorectal carcinoma patients under low molecular weight heparin thromboprophylaxis. PMID: 23022759 Ref: Changed adipocytokine concentrations in colorectal tumor patients and morbidly obese patients compared to healthy controls. PMID: 23173608 |
Ref: Plasminogen activator inhibitor-1 is increased in colonic epithelial cells from patients with colitis-associated cancer. PMID: 22921465 Ref: Clinical impact of PAI 1 4G/5G gene polymorphism in colorectal carcinoma patients. PMID: 23259783 Ref: ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304 Ref: PAI-1 4G/5G polymorphism contributes to cancer susceptibility: evidence from meta-analysis. PMID: 23437240 Ref: Prognostic role of tumor-associated proteases in colorectal cancer. PMID: 23484202 Ref: MTHFR Glu429Ala and ERCC5 His46His polymorphisms are associated with prognosis in colorectal cancer patients: analysis of two independent cohorts from Newfoundland. PMID: 23626689 Ref: Impact of mesenchymal stem cell secreted PAI-1 on colon cancer cell migration and proliferation. PMID: 23685140 Ref: [Clinical prospects of tumor-associated proteases and their tissue inhibitors investigation in oncologic patient]. PMID: 24000664 Ref: Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms. PMID: 24073308 Ref: Type 1 plasminogen activator inhibitor as a common risk factor for cancer and ischaemic vascular disease: the EPICOR study. PMID: 24231461 |
Ref: Interaction with colon cancer cells hyperactivates TGF-beta signaling in cancer-associated fibroblasts. PMID: 23208491 Ref: Secretome profiling reveals the signaling molecules of apoptotic HCT116 cells induced by the dietary polyacetylene gymnasterkoreayne B. PMID: 24571669 Ref: The presence of clustered circulating tumor cells (CTCs) and circulating cytokines define an aggressive phenotype in metastatic colorectal cancer. PMID: 25135616 Ref: Discovery of melanotransferrin as a serological marker of colorectal cancer by secretome analysis and quantitative proteomics. PMID: 25216327 |
Ref: Silencing of plasminogen activator inhibitor-1 suppresses colorectal cancer progression and liver metastasis. PMID: 26275833 Ref: Genetic polymorphisms of PAI-1 and PAR-1 are associated with acute normal tissue toxicity in Chinese rectal cancer patients treated with pelvic radiotherapy. PMID: 26347502 |
Ref: Cholest-4-en-3-one attenuates TGF-beta responsiveness by inducing TGF-beta receptors degradation in Mv1Lu cells and colorectal adenocarcinoma cells. PMID: 27401208 Ref: Oxymatrine inhibits the migration of human colorectal carcinoma RKO cells via inhibition of PAI-1 and the TGF-beta1/Smad signaling pathway. PMID: 27959430 Ref: Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. PMID: 28286517 Ref: ING2, a tumor associated gene, enhances PAI1 and HSPA1A expression with HDAC1 and mSin3A through the PHD domain and Cterminal. PMID: 28944862 Ref: Identification of Key Genes in Colorectal Cancer Regulated by miR-34a. PMID: 29197895 |
Ref: Preliminary Study of the Role F-Box Protein 32 (FBXO32) in Colorectal Neoplasms Through the Transforming Growth Factor beta (TGF-beta)/Smad4 Signalling Pathway. PMID: 29465067 Ref: Overexpression of Rab11-FIP2 in colorectal cancer cells promotes tumor migration and angiogenesis through increasing secretion of PAI-1. PMID: 29540997 Ref: Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice via Increasing Levels of IL6R and PAI1. PMID: 30099074 Ref: Computational analysis of mRNA expression profiles identifies a novel triple-biomarker model as prognostic predictor of stage II and III colorectal adenocarcinoma patients. PMID: 30214289 |