Primary Site >> Biliary tract Cancer

Gene >> RUNX3

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  • 2016
Ref: Aberrant promoter hypermethylation of multiple genes in gallbladder carcinoma and chronic cholecystitis.
PMID: 15447999
Ref: Promoter hypermethylation of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.
PMID: 15471559
 Ref: Restoration of RUNX3 enhances transforming growth factor-beta-dependent p21 expression in a biliary tract cancer cell line.
PMID: 17470130
 Ref: CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma.
PMID: 19763613
Ref: DNA copy-number loss on 1p36.1 harboring RUNX3 with promoter hypermethylation and associated loss of RUNX3 expression in liver fluke-associated intrahepatic cholangiocarcinoma.
PMID: 19827872
 Ref: Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis.
PMID: 21205092
 Ref: Bile-based detection of extrahepatic cholangiocarcinoma with quantitative DNA methylation markers and its high sensitivity.
PMID: 22446083
 Ref: Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.
PMID: 23555160
 Ref: EZH2 elevates the proliferation of human cholangiocarcinoma cells through the downregulation of RUNX3.
PMID: 25280519
 Ref: Two classes of intrahepatic cholangiocarcinoma defined by relative abundance of mutations and copy number alterations.
PMID: 27009864