Primary Site >> Colorectal Cancer
Gene >> RSPO3
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Ref: Recurrent R-spondin fusions in colon cancer. PMID: 22895193 |
Ref: RSPO fusion transcripts in colorectal cancer in Japanese population. PMID: 24847761 |
Ref: Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. PMID: 25531322 |
Ref: Wnt addiction of genetically defined cancers reversed by PORCN inhibition. PMID: 26257057 Ref: Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function. PMID: 26700806 |
Ref: RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis. PMID: 27511199 Ref: Loss of AXIN1 drives acquired resistance to WNT pathway blockade in colorectal cancer cells carrying RSPO3 fusions. PMID: 28100566 Ref: Molecular genetics and targeted therapy of WNT-related human diseases (Review). PMID: 28731148 Ref: RSPO3 antagonism inhibits growth and tumorigenicity in colorectal tumors harboring common Wnt pathway mutations. PMID: 29127379 Ref: Investigation of fusion gene expression in HCT116 cells. PMID: 29181107 |