Primary Site >> Colorectal Cancer

Gene >> RRM2B

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Ref: Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.
PMID: 15096505
Ref: Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls.
PMID: 16127747
Ref: Ribonucleotide reductase subunits M2 and p53R2 are potential biomarkers for metastasis of colon cancer.
PMID: 17311703
Ref: Reprimo 824 G>C and p53R2 4696 C>G single nucleotide polymorphisms and colorectal cancer: a case-control disease association study.
PMID: 18197409
Ref: E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
PMID: 19585502
Ref: Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 protein.
PMID: 19929413
Ref: Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer.
PMID: 21415168
Ref: The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status.
PMID: 26980146
Ref: Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3.
PMID: 28580901
Ref: miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
PMID: 29731918