Primary Site >> Colorectal Cancer
Gene >> RET
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Ref: [Genetic predisposition to cancer: familial forms of medullary thyroid cancer and breast cancer]. PMID: 8038990 |
Ref: Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF-receptor ligand and adhesion molecule expression. PMID: 7601566 |
Ref: [Familial cancer and oncogenic factors]. PMID: 8678487 |
Ref: Advances in molecular genetics. PMID: 9046882 Ref: Cancer genetics in the new era of molecular biology. PMID: 9616736 |
Ref: [Dependence receptors: links between apoptosis, nervous system development and control of tumorigenesis]. PMID: 10969210 |
Ref: Microsatellite instability in thyroid cancer: hot spots, clinicopathological implications, and prognostic significance. PMID: 11705861 |
Ref: High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. PMID: 12670889 |
Ref: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. PMID: 14963042 Ref: [Familial tumor syndrome and ectopic hormone-producing tumors]. PMID: 15148809 |
Ref: Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases. PMID: 16688779 Ref: Sequence-dependent inhibition of human colon cancer cell growth and of prosurvival pathways by oxaliplatin in combination with ZD6474 (Zactima), an inhibitor of VEGFR and EGFR tyrosine kinases. PMID: 16891475 Ref: BRAF mutations in papillary thyroid carcinoma. PMID: 17201587 |
Ref: Sunitinib: from rational design to clinical efficacy. PMID: 17327610 Ref: The relationship between GDNF and integrins in human colorectal cancer cell activity. PMID: 17708263 |
Ref: Sixty years of follow-up of Hiroshima and Nagasaki survivors: current progress in molecular epidemiology studies. PMID: 18406659 Ref: Inherited cancer predisposition syndromes in Greece. PMID: 18505076 |
Ref: Open-label phase I trial of vandetanib in combination with mFOLFOX6 in patients with advanced colorectal cancer. PMID: 19002384 Ref: F-18 FDG PET detection of a medullary thyroid carcinoma in a patient with metastatic colonic cancer; literature review. PMID: 19744643 Ref: Distinct high-profile methylated genes in colorectal cancer. PMID: 19750230 Ref: DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study. PMID: 19946413 |
Ref: Sulindac reverses aberrant expression and localization of beta-catenin in papillary thyroid cancer cells with the BRAFV600E mutation. PMID: 20470206 |
Ref: Development of RET kinase inhibitors for targeted cancer therapy. PMID: 21110809 Ref: Novel classification and pathogenetic analysis of hypoganglionosis and adult-onset Hirschsprung's disease. PMID: 21222160 Ref: Enteric neurons synthesize netrins and are essential for the development of the vagal sensory innervation of the fetal gut. PMID: 21485011 Ref: Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell type. PMID: 21812966 Ref: Drug therapy for hereditary cancers. PMID: 21819606 Ref: Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors. PMID: 22174910 |
Ref: Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. PMID: 22327622 Ref: Silencing of CCDC6 reduces the expression of 14-3-3sigma in colorectal carcinoma cells. PMID: 22399611 Ref: A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. PMID: 22421192 Ref: Increased cellular distribution of vimentin and Ret in the cingulum induced by developmental hypothyroidism in rat offspring maternally exposed to anti-thyroid agents. PMID: 22504374 Ref: Regorafenib for cancer. PMID: 22577890 Ref: KIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung. PMID: 22797671 |
Ref: RET is a potential tumor suppressor gene in colorectal cancer. PMID: 22751117 Ref: Regorafenib for gastrointestinal malignancies : from preclinical data to clinical results of a novel multi-target inhibitor. PMID: 23435872 Ref: Critical appraisal of the use of regorafenib in the management of colorectal cancer. PMID: 23610528 Ref: Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase. PMID: 23811235 Ref: Site-specific gene expression and localization of growth factor ligand receptors RET, GFRalpha1 and GFRalpha2 in human adult colon. PMID: 23881409 |
Ref: An integrative CGH, MSI and candidate genes methylation analysis of colorectal tumors. PMID: 24475022 Ref: Promoter CpG island methylation of RET predicts poor prognosis in stage II colorectal cancer patients. PMID: 24560444 Ref: Vascular effects, efficacy and safety of nintedanib in patients with advanced, refractory colorectal cancer: a prospective phase I subanalysis. PMID: 25012508 Ref: Dependence receptors and colorectal cancer. PMID: 25163468 |
Ref: The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets. PMID: 25926053 Ref: Identification and characterization of RET fusions in advanced colorectal cancer. PMID: 26078337 Ref: Activation of 5-HT4 receptors facilitates neurogenesis of injured enteric neurons at an anastomosis in the lower gut. PMID: 26658112 |
Ref: Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells. PMID: 26419617 Ref: Identification of Targetable Kinase Alterations in Patients with Colorectal Carcinoma That are Preferentially Associated with Wild-Type RAS/RAF. PMID: 26660078 Ref: EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile. PMID: 26810733 Ref: Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma. PMID: 26865419 Ref: Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment. PMID: 26909603 Ref: Determination of somatic oncogenic mutations linked to target-based therapies using MassARRAY technology. PMID: 26968814 Ref: Analysis of RET promoter CpG island methylation using methylation-specific PCR (MSP), pyrosequencing, and methylation-sensitive high-resolution melting (MS-HRM): impact on stage II colon cancer patient outcome. PMID: 27118999 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. PMID: 27458094 Ref: Cytotoxic and targeted therapy for hereditary cancers. PMID: 27555886 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study. PMID: 28050146 |
Ref: Whole-exome sequencing identified mutational profiles of high-grade colon adenomas. PMID: 28179590 Ref: Hyper-Methylated Loci Persisting from Sessile Serrated Polyps to Serrated Cancers. PMID: 28257124 Ref: A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer. PMID: 28512242 Ref: Morphology with immunohistochemical and genetic profiling of high-grade neuroendocrine carcinoma of colon - a case report with review of literature. PMID: 28730258 |
Ref: [A Case of Rectal Cancer with Multiple Endocrine Neoplasia Type 2]. PMID: 29362346 Ref: RET fusions in a small subset of advanced colorectal cancers at risk of being neglected. PMID: 29538669 Ref: Evolution of regorafenib from bench to bedside in colorectal cancer: Is it an attractive option or merely a "me too" drug? PMID: 29563833 Ref: RET-fusions: a novel paradigm in colorectal cancer. PMID: 29648570 Ref: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene. PMID: 29665843 Ref: Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene. PMID: 29859122 Ref: Genomic Profiling Reveals Medullary Thyroid Cancer Misdiagnosed as Lung Cancer. PMID: 30022943 Ref: Lenvatinib: A Promising Molecular Targeted Agent for Multiple Cancers. PMID: 30032643 Ref: NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines. PMID: 30210625 |