Primary Site >> Colorectal Cancer
Gene >> RB1
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Ref: [Combined radiotherapy and local external hyperthermia in advanced cancer--animal experiment and clinical study]. PMID: 3616262 |
Ref: Multistage carcinogenesis in paediatric and adult cancers. PMID: 1314630 Ref: No alterations in exon 21 of the RB1 gene in sarcomas and carcinomas of the breast, colon, and lung. PMID: 1381957 Ref: [Complex characteristics of the alterations of oncogenes HER-2/ERBB-2, HER-1/ERBB-1, HRAS-1, C-MYC and antioncogenes p53, RB1, as well as deletions of loci of chromosome 17 in colon carcinoma]. PMID: 1470178 Ref: Transforming growth factor beta 1 (TGF-beta 1) inhibits retinoblastoma gene expression but not pRB phosphorylation in TGF-beta 1-growth stimulated colon carcinoma cells. PMID: 1565477 Ref: Abundance and state of phosphorylation of the retinoblastoma susceptibility gene product in human colon cancer. PMID: 1584201 Ref: Molecular genetic studies of tumor suppressor gene regions on chromosomes 13 and 17 in colorectal tumors. PMID: 1619684 |
Ref: Effect of sodium butyrate on the expression of retinoblastoma (RB1) and P53 gene and phosphorylation of retinoblastoma protein in human colon tumor cell line HT29. PMID: 8220069 Ref: Retinoblastoma gene product-associated proteins in human colon cancer cell lines. PMID: 8343169 Ref: RB1 protein in normal and malignant human colorectal tissue and colon cancer cell lines. PMID: 8344490 |
Ref: Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. PMID: 7947085 Ref: The PRAD-1/cyclin D1 oncogene product accumulates aberrantly in a subset of colorectal carcinomas. PMID: 8056453 Ref: Immunohistochemical study of retinoblastoma gene-expression in colorectal carcinomas. PMID: 21566899 |
Ref: Cell cycle dependent effects of u.v.-radiation on p53 expression and retinoblastoma protein phosphorylation. PMID: 7624123 Ref: Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer. PMID: 7779716 |
Ref: The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins. PMID: 8632912 Ref: Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4. PMID: 8634094 Ref: Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease. PMID: 8674385 Ref: [RB gene expression in gastrointestinal tract]. PMID: 8920658 Ref: [Cyclin D, CDK4 and p16 expression in colorectal cancer]. PMID: 8920673 |
Ref: p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? PMID: 9000603 Ref: The p53-regulated cyclin G gene promotes cell growth: p53 downstream effectors cyclin G and Gadd45 exert different effects on cisplatin chemosensitivity. PMID: 9013707 Ref: Enterocyte differentiation is compatible with SV40 large T expression and loss of p53 function in human colonic Caco-2 cells. Status of the pRb1 and pRb2 tumor suppressor gene products. PMID: 9136893 Ref: Colonic retinoblastoma protein and proliferation in cancer and non-cancer patients. PMID: 9142634 Ref: Retinoblastoma (pRb) protein immunoexpression in colorectal cancer. PMID: 9252686 Ref: Expressions of cell cycle regulators in human colorectal cancer cell lines. PMID: 9369933 |
Ref: A comparison of the genetic pathways involved in the pathogenesis of three types of colorectal cancer. PMID: 9602705 Ref: Retinoblastoma and p53 protein expression in sporadic colorectal cancers. PMID: 9800976 Ref: Sodium butyrate induces retinoblastoma protein dephosphorylation, p16 expression and growth arrest of colon cancer cells. PMID: 9823007 Ref: Expression of cyclin D1 and retinoblastoma protein in colorectal cancer. PMID: 9893631 |
Ref: Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a). PMID: 10207115 Ref: An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. PMID: 10359525 Ref: Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization. PMID: 10398135 Ref: Paradoxical increase in retinoblastoma protein in colorectal carcinomas may protect cells from apoptosis. PMID: 10430085 Ref: Immunohistochemical evaluation of cathepsin D expression in colorectal tumours: a correlation with extracellular matrix components, p53, pRb, bcl-2, c-erbB-2, EGFR and proliferation indices. PMID: 10470163 Ref: Inactivation of p53 and of pRb protects human colorectal carcinoma cells against hyperthermia-induced cytotoxicity and apoptosis. PMID: 10473867 Ref: G1-checkpoint function including a cyclin-dependent kinase 2 regulatory pathway as potential determinant of 7-hydroxystaurosporine (UCN-01)-induced apoptosis and G1-phase accumulation. PMID: 10665655 |
Ref: Protein expression of p53, p21 (WAF1/CIP1), bcl-2, Bax, cyclin D1 and pRb in human colon carcinomas. PMID: 10782880 Ref: Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. PMID: 10783304 Ref: Downregulation of cyclin D1 alters cdk 4- and cdk 2-specific phosphorylation of retinoblastoma protein. PMID: 11032757 Ref: Cell cycle regulation of the G0/G1 transition in 5-fluorouracil-sensitive and -resistant human colon cancer cell lines. PMID: 11038143 Ref: Expression of pRB, cyclin/cyclin-dependent kinases and E2F1/DP-1 in human tumor lines in cell culture and in xenograft tissues and response to cell cycle agents. PMID: 11052627 Ref: A vitamin D3 analog induces a G1-phase arrest in CaCo-2 cells by inhibiting cdk2 and cdk6: roles of cyclin E, p21Waf1, and p27Kip1. PMID: 11089522 Ref: Human colorectal cancers with an intact p16/cyclin D1/pRb pathway have up-regulated p16 expression and decreased proliferation in small invasive tumor clusters. PMID: 11106567 Ref: Mechanism of cell cycle arrest caused by histone deacetylase inhibitors in human carcinoma cells. PMID: 11132966 |
Ref: Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells. PMID: 11207048 Ref: Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. PMID: 11259469 Ref: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit. PMID: 11489836 Ref: A novel cdk2-selective inhibitor, SU9516, induces apoptosis in colon carcinoma cells. PMID: 11507069 |
Ref: Analysis of key cell-cycle checkpoint proteins in colorectal tumours. PMID: 11920733 Ref: Role of retinoblastoma protein and E2F-1 transcription factor in the acquisition of 5-fluorouracil resistance by colon cancer cells. PMID: 12118326 Ref: Efficient repair of bulky anti-BPDE DNA adducts from non-transcribed DNA strand requires functional p53 but not p21(waf1/cip1) and pRb. PMID: 12175902 Ref: SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells. PMID: 12234612 Ref: Suppression of tumor growth through introduction of an antisense plasmid of macrophage migration inhibitory factor. PMID: 12373295 Ref: Screening for microsatellite instability target genes in colorectal cancers. PMID: 12414815 Ref: Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest. PMID: 12460790 |
Ref: [Soft tissue pathologies of the oral cavity]. PMID: 12686915 Ref: The dominant-negative effect of p53 mutants and p21 induction in tetraploid G1 arrest depends on the type of p53 mutation and the nature of the stimulus. PMID: 12742155 Ref: The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines. PMID: 12845674 Ref: Cdx1 inhibits the proliferation of human colon cancer cells by reducing cyclin D1 gene expression. PMID: 14508520 Ref: Glucocorticoid receptor (GR) immunohistochemical expression is correlated with cell cycle-related molecules in human colon cancer. PMID: 14560994 Ref: Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells. PMID: 14608092 |
Ref: The nucleocytoplasmic shuttling of E2F4 is involved in the regulation of human intestinal epithelial cell proliferation and differentiation. PMID: 15040009 Ref: CD44 negatively regulates apoptosis in murine colonic epithelium via the mitochondrial pathway. PMID: 15126101 Ref: Expression of MCM10 and TopBP1 is regulated by cell proliferation and UV irradiation via the E2F transcription factor. PMID: 15195143 Ref: Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells. PMID: 15202011 Ref: Thermal enhancement of oxaliplatin-induced inhibition of cell proliferation and cell cycle progression in human carcinoma cell lines. PMID: 15204521 Ref: CD44 promotes resistance to apoptosis in human colon cancer cells. PMID: 15215046 Ref: Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. PMID: 15221933 Ref: Unravelling the genetics of prostate cancer. PMID: 15264274 Ref: Autocrine and exogenous transforming growth factor beta control cell cycle inhibition through pathways with different sensitivity. PMID: 15271980 Ref: Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21(Waf1/Cip1). PMID: 15317660 Ref: Detection of allelic imbalance in the gene expression of hMSH2 or RB1 in lymphocytes from pedigrees of hereditary, nonpolyposis, colorectal cancer and retinoblastoma by an RNA difference plot. PMID: 15480874 Ref: Prognostic significance of pRb family and p16(INK4) alterations in colorectal cancer: an interesting point of view in a complex net of molecular signals. PMID: 15492982 Ref: Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma. PMID: 15492985 Ref: Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. PMID: 15542782 |
Ref: Progressive methylation during the serrated neoplasia pathway of the colorectum. PMID: 15389252 Ref: Genotype phenotype correlations in Israeli colorectal cancer patients. PMID: 15523694 Ref: Tumorigenesis in p27/p53- and p18/p53-double null mice: functional collaboration between the pRb and p53 pathways. PMID: 15584024 Ref: Gene-directed enzyme prodrug therapy with carboxylesterase enhances the anticancer efficacy of the conditionally replicating adenovirus AdDelta24. PMID: 15729367 Ref: Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. PMID: 15867357 Ref: A cancer-specific transcriptional signature in human neoplasia. PMID: 16224537 Ref: Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. PMID: 16236452 Ref: [Clinical significance of cyclin Dl expression in non-small cell lung cancer]. PMID: 16989170 |
Ref: Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer. PMID: 15885887 Ref: CtIP, a candidate tumor susceptibility gene is a team player with luminaries. PMID: 16249056 Ref: Cyclin D1 and Rb protein expression and their correlation with prognosis in patients with colon cancer. PMID: 16426443 Ref: Profiling markers of prognosis in colorectal cancer. PMID: 16489072 Ref: Methoxyamine potentiates iododeoxyuridine-induced radiosensitization by altering cell cycle kinetics and enhancing senescence. PMID: 16648559 Ref: DEK Expression is controlled by E2F and deregulated in diverse tumor types. PMID: 16721057 Ref: Lap2alpha expression is controlled by E2F and deregulated in various human tumors. PMID: 16760672 Ref: Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). PMID: 16820966 |
Ref: Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells. PMID: 17009031 Ref: Differential apoptosis by gallotannin in human colon cancer cells with distinct p53 status. PMID: 17192871 Ref: Expression of peroxisome proliferator-activated receptor-gamma in colon cancer: correlation with histopathological parameters, cell cycle-related molecules, and patients' survival. PMID: 17393321 Ref: Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation. PMID: 17909036 |
Ref: Microarray analysis reveals that leptin induces autocrine/paracrine cascades to promote survival and proliferation of colon epithelial cells in an Apc genotype-dependent fashion. PMID: 17620308 Ref: Prognostic and predictive value of thymidylate synthase expression in colon cancer. PMID: 17934851 Ref: PEITC induces G1 cell cycle arrest on HT-29 cells through the activation of p38 MAPK signaling pathway. PMID: 18473178 Ref: Familial adenomatous polyposis: analysis of genetic instability of microsatellites Loci and genetic alternations of tumor suppressor genes. PMID: 18498268 Ref: E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. PMID: 18521084 Ref: In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation. PMID: 18524847 Ref: Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. PMID: 18701096 Ref: Lamin A/C is a risk biomarker in colorectal cancer. PMID: 18714339 Ref: Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin. PMID: 18771933 Ref: Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. PMID: 18832169 Ref: Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. PMID: 18948598 Ref: Microsatellite instability and loss of heterozygosity of tumor suppressor genes in Bosnian patients with sporadic colorectal cancer. PMID: 19125701 Ref: [Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]. PMID: 19140325 Ref: Expression patterns of cyclins D1, E and cyclin-dependent kinase inhibitors p21waf1/cip1, p27kip1 in colorectal carcinoma: correlation with other cell cycle regulators (pRb, p53 and Ki-67 and PCNA) and clinicopathological features. PMID: 19143860 Ref: Sex modulates intestinal transformation by the tumor-suppressor GCC. PMID: 20443837 |
Ref: The mitochondrial pathway is involved in American ginseng-induced apoptosis of SW-480 colon cancer cells. PMID: 19212614 Ref: [Involvement of human papillomavirus in upper aero-digestive tracts cancers]. PMID: 19744917 Ref: Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention. PMID: 19787257 Ref: Screening for microsatellite instability identifies frequent 3'-untranslated region mutation of the RB1-inducible coiled-coil 1 gene in colon tumors. PMID: 19888451 |
Ref: PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. PMID: 20372802 Ref: Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. PMID: 20423983 Ref: A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. PMID: 20615460 Ref: Irinotecan overcomes the resistance to 5-fluorouracil in human colon cancer xenografts by down-regulation of intratumoral thymidylate synthase. PMID: 20811661 Ref: Genetic profiles distinguish different types of hereditary ovarian cancer. PMID: 20811668 Ref: Molecular prognostic factors in rectal cancer treated by preoperative chemoradiotherapy. PMID: 22966250 |
Ref: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling. PMID: 21600193 Ref: Molecular basis for the actions of Hsp90 inhibitors and cancer therapy. PMID: 21811259 Ref: NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. PMID: 21952639 |
Ref: DNA methylation patterns in blood of patients with colorectal cancer and adenomatous colorectal polyps. PMID: 22020530 Ref: Role of p21 as a determinant of 1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane response in human HCT-116 colon carcinoma cells. PMID: 22076474 Ref: An integrated genomic approach to identify predictive biomarkers of response to the aurora kinase inhibitor PF-03814735. PMID: 22222631 Ref: Ginsenoside compound K, not Rb1, possesses potential chemopreventive activities in human colorectal cancer. PMID: 22426808 Ref: The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells. PMID: 23059827 |
Ref: miR-106a overexpression and pRB downregulation in sporadic colorectal cancer. PMID: 23178825 Ref: Suppression of Src/ERK and GSK-3/beta-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. PMID: 23333577 Ref: Boletus edulis biologically active biopolymers induce cell cycle arrest in human colon adenocarcinoma cells. PMID: 23370594 Ref: Melanoidins isolated from heated potato fiber (Potex) affect human colon cancer cells growth via modulation of cell cycle and proliferation regulatory proteins. PMID: 23583803 Ref: Epithelial-specific deletion of 11beta-HSD2 hinders Apcmin/+ mouse tumorigenesis. PMID: 23741059 Ref: Expression of cell cycle regulatory factors hus1, gadd45a, rb1, cdkn2a and mre11a correlates with expression of clock gene per2 in human colorectal carcinoma tissue. PMID: 24062075 Ref: BRAF V600E is a determinant of sensitivity to proteasome inhibitors. PMID: 24107445 Ref: Antiproliferative effects of protopanaxadiol ginsenosides on human colorectal cancer cells. PMID: 24648985 |
Ref: Commonality and differences of methylation signatures in the plasma of patients with pancreatic cancer and colorectal cancer. PMID: 24288256 Ref: The fermented non-digestible fraction of common bean (Phaseolus vulgaris L.) triggers cell cycle arrest and apoptosis in human colon adenocarcinoma cells. PMID: 24293398 Ref: microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma. PMID: 24647829 Ref: The mechanisms of 5-FU-PLA-O-CMC-NPS-mediated inhibition of the proliferation of colorectal cancer cell line SW480. PMID: 24740560 Ref: CSNK1E/CTNNB1 are synthetic lethal to TP53 in colorectal cancer and are markers for prognosis. PMID: 24947187 Ref: Immune response to JC virus T antigen in patients with and without colorectal neoplasia. PMID: 25007286 Ref: HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy. PMID: 25296971 |
Ref: HGUE-C-1 is an atypical and novel colon carcinoma cell line. PMID: 25885658 Ref: Radiation-induced microRNA-622 causes radioresistance in colorectal cancer cells by down-regulating Rb. PMID: 25961730 Ref: Anticolorectal cancer effects and pharmacokinetic application of 2, 2-Bis [4-(4-amino-3-hydroxyphenoxy) phenyl] adamantane. PMID: 26628962 |
Ref: Quantitation of eleven active compounds of Aidi injection in rat plasma and its application to comparative pharmacokinetic study. PMID: 26277443 Ref: Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells. PMID: 26514676 Ref: ANRIL regulates the proliferation of human colorectal cancer cells in both two- and three-dimensional culture. PMID: 26708220 Ref: Integrated analysis of DNA methylation and mutations in esophageal squamous cell carcinoma. PMID: 26756304 Ref: The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. PMID: 26861731 Ref: OncoScape: Exploring the cancer aberration landscape by genomic data fusion. PMID: 27321817 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-beta-Catenin Signaling in Colorectal Cancer. PMID: 27789274 Ref: [Inhibitory effect of jianpi-jiedu prescription-contained serum on colorectal cancer SW48 cell proliferation by mTOR-P53-P21 signalling pathway]. PMID: 27932756 |
Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Review on the role of the human Polyomavirus JC in the development of tumors. PMID: 28174598 Ref: Cell-Cycle Regulation Accounts for Variability in Ki-67 Expression Levels. PMID: 28283655 Ref: MiR-26a downregulates retinoblastoma in colorectal cancer. PMID: 28443472 Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 28460341 Ref: Induction of p53-Independent Apoptosis and G1 Cell Cycle Arrest by Fucoidan in HCT116 Human Colorectal Carcinoma Cells. PMID: 28555064 Ref: The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer. PMID: 28675510 Ref: Morphology with immunohistochemical and genetic profiling of high-grade neuroendocrine carcinoma of colon - a case report with review of literature. PMID: 28730258 Ref: Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer. PMID: 28794688 |
Ref: Synthesis, Characterization of 4-Anilino-6,7-Dimethoxy Quinazoline Derivatives as Potential Anti-Angiogenic Agents. PMID: 28403784 Ref: Cdc37 facilitates cell survival of colorectal carcinoma via activating the CDK4 signaling pathway. PMID: 29288563 Ref: Insulin receptor substrate-4 is overexpressed in colorectal cancer and promotes retinoblastoma-cyclin-dependent kinase activation. PMID: 29353348 Ref: Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis. PMID: 29443735 Ref: Nemo-like kinase (NLK) primes colorectal cancer progression by releasing the E2F1 complex from HDAC1. PMID: 29803790 |