Primary Site >> Colorectal Cancer
Gene >> RAG2
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Ref: CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice. PMID: 12547727 Ref: CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. PMID: 14522933 |
Ref: Antitumor activity of chimeric immunoreceptor gene-modified Tc1 and Th1 cells against autologous carcinoembryonic antigen-expressing colon cancer cells. PMID: 16856879 Ref: Innate immune inflammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. PMID: 16885333 |
Ref: Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. PMID: 17724375 |
Ref: Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse. PMID: 18411292 Ref: Cytotoxic-T-lymphocyte-associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. PMID: 18824539 |
Ref: Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer. PMID: 19119184 Ref: Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice. PMID: 19164562 Ref: Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. PMID: 19732721 |
Ref: Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. PMID: 21482794 Ref: Runx3 is required for full activation of regulatory T cells to prevent colitis-associated tumor formation. PMID: 21515792 |
Ref: Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer. PMID: 22366582 Ref: Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. PMID: 22689960 |
Ref: Treatment of colorectal cancer using a combination of liposomal irinotecan (Irinophore C) and 5-fluorouracil. PMID: 23626804 Ref: Characterization of dextran sodium sulfate-induced inflammation and colonic tumorigenesis in Smad3(-/-) mice with dysregulated TGFbeta. PMID: 24244446 |
Ref: Perforin-dependent direct cytotoxicity in natural killer cells induces considerable knockdown of spontaneous lung metastases and computer modelling-proven tumor cell dormancy in a HT29 human colon cancer xenograft mouse model. PMID: 25373310 |
Ref: Helicobacter cinaedi induced typhlocolitis in Rag-2-deficient mice. PMID: 25381744 Ref: Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rgammanull Immunodeficient Mice. PMID: 26113085 |
Ref: Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer. PMID: 28198364 Ref: MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. PMID: 28686677 |
Ref: Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15. PMID: 29308327 |