Primary Site >> Colorectal Cancer
Gene >> RAD51
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. PMID: 10362364 |
Ref: Identification of Rad51 alteration in patients with bilateral breast cancer. PMID: 10807537 |
Ref: Hypersensitivity to camptothecin in MSH2 deficient cells is correlated with a role for MSH2 protein in recombinational repair. PMID: 11698339 |
Ref: The mammalian mismatch repair protein MSH2 is required for correct MRE11 and RAD51 relocalization and for efficient cell cycle arrest induced by ionizing radiation in G2 phase. PMID: 12687013 |
Ref: Immunoprofiles of 11 biomarkers using tissue microarrays identify prognostic subgroups in colorectal cancer. PMID: 16207476 |
Ref: p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line. PMID: 16516153 Ref: Haploinsufficiency of RAD51B causes centrosome fragmentation and aneuploidy in human cells. PMID: 16778173 Ref: Gene expression in tumor-adjacent normal tissue is associated with recurrence in patients with rectal cancer treated with adjuvant chemoradiation. PMID: 16847424 Ref: Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. PMID: 17241515 |
Ref: The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner. PMID: 18381438 Ref: Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins. PMID: 18566216 |
Ref: The level of oxidative stress and the expression of genes involved in DNA-damage signaling pathways in depressive patients with colorectal carcinoma. PMID: 19232240 Ref: Functional evidence for Eme1 as a marker of cisplatin resistance. PMID: 19267403 Ref: [The role of RAD 51 gene polymorphism in patients with colorectal cancer in the Polish subpopulation]. PMID: 19606696 Ref: Differential cellular responses to prolonged LDR-IR in MLH1-proficient and MLH1-deficient colorectal cancer HCT116 cells. PMID: 19861440 |
Ref: Cellular responses to etoposide: cell death despite cell cycle arrest and repair of DNA damage. PMID: 20041303 |
Ref: Polymorphisms in RAD51, XRCC2 and XRCC3 genes of the homologous recombination repair in colorectal cancer--a case control study. PMID: 21104022 Ref: Common fragile sites in colon cancer cell lines: role of mismatch repair, RAD51 and poly(ADP-ribose) polymerase-1. PMID: 21570414 Ref: Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. PMID: 21875941 Ref: GAIP-interacting protein, C-terminus is involved in the induction of zinc-finger protein 143 in response to insulin-like growth factor-1 in colon cancer cells. PMID: 21909943 |
Ref: Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells. PMID: 21221710 Ref: The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. PMID: 21559836 Ref: Platelet-derived endothelial cell growth factor/thymidine phosphorylase inhibitor augments radiotherapeutic efficacy in experimental colorectal cancer. PMID: 22178656 Ref: (212)Pb-radioimmunotherapy induces G(2) cell-cycle arrest and delays DNA damage repair in tumor xenografts in a model for disseminated intraperitoneal disease. PMID: 22238365 Ref: Evaluation of relation of RAD51 and the effect of chemo-radiation therapy for advanced rectal cancer. PMID: 22580645 Ref: Lack of association between the 135G/C RAD51 gene polymorphism and the risk of colorectal cancer among Polish population. PMID: 22935458 Ref: RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland. PMID: 23161237 |
Ref: RAD51 overexpression is a negative prognostic marker for colorectal adenocarcinoma. PMID: 23065657 Ref: Sensitization of tumor to (2)(1)(2)Pb radioimmunotherapy by gemcitabine involves initial abrogation of G2 arrest and blocked DNA damage repair by interference with Rad51. PMID: 23200172 Ref: PES1 regulates sensitivity of colorectal cancer cells to anticancer drugs. PMID: 23333390 Ref: MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells. PMID: 23724141 Ref: Keratin23 (KRT23) knockdown decreases proliferation and affects the DNA damage response of colon cancer cells. PMID: 24039993 |
Ref: Excision Repair Cross-Complementation group 1 (ERCC1) C118T SNP does not affect cellular response to oxaliplatin. PMID: 24220697 Ref: RAD51 Gene 135G/C polymorphism and the risk of four types of common cancers: a meta-analysis. PMID: 24457040 Ref: The use of Olaparib (AZD2281) potentiates SN-38 cytotoxicity in colon cancer cells by indirect inhibition of Rad51-mediated repair of DNA double-strand breaks. PMID: 24577941 Ref: Genetic 135G/C polymorphism of RAD51 gene and risk of cancer: a meta-analysis of 28,956 cases and 28,372 controls. PMID: 24859942 Ref: RAD51 G135C gene polymorphism and risk of colorectal cancer in Kashmir. PMID: 24871558 Ref: Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells. PMID: 24956373 Ref: Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. PMID: 25043256 Ref: Mitotic crossover--an evolutionary rudiment which promotes carcinogenesis of colorectal carcinoma. PMID: 25253953 Ref: Phase 1/2 study of valproic acid and short-course radiotherapy plus capecitabine as preoperative treatment in low-moderate risk rectal cancer-V-shoRT-R3 (Valproic acid--short Radiotherapy--rectum 3rd trial). PMID: 25421252 |
Ref: The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage. PMID: 24912782 Ref: Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition. PMID: 25388513 Ref: Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation. PMID: 25589620 Ref: 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair. PMID: 25909291 Ref: Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population. PMID: 26617897 |
Ref: mTORC1 and DNA-PKcs as novel molecular determinants of sensitivity to Chk1 inhibition. PMID: 26471831 Ref: Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy. PMID: 26676960 Ref: KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis. PMID: 26839262 Ref: Expression of an Oncogenic BARD1 Splice Variant Impairs Homologous Recombination and Predicts Response to PARP-1 Inhibitor Therapy in Colon Cancer. PMID: 27197561 Ref: Fibroblast growth factor receptor 4 induced resistance to radiation therapy in colorectal cancer. PMID: 27650548 |
Ref: Potential Role of Single Nucleotide Polymorphisms of XRCC1, XRCC3, and RAD51 in Predicting Acute Toxicity in Rectal Cancer Patients Treated With Preoperative Radiochemotherapy. PMID: 25811296 Ref: Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. PMID: 28099437 Ref: Enhanced dependency of KRAS-mutant colorectal cancer cells on RAD51-dependent homologous recombination repair identified from genetic interactions in Saccharomyces cerevisiae. PMID: 28173629 Ref: YPC-21661 and YPC-22026, novel small molecules, inhibit ZNF143 activity in vitro and in vivo. PMID: 28192620 Ref: Schizosaccharomyces pombe MutSalpha and MutLalpha Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats. PMID: 28341698 Ref: A novel function of hepatocyte growth factor in the activation of checkpoint kinase 1 phosphorylation in colon cancer cells. PMID: 28573382 Ref: BRCA2, EGFR, and NTRK mutations in mismatch repair-deficient colorectal cancers with MSH2 or MLH1 mutations. PMID: 28591715 Ref: XPG Asp1104His, XRCC2 Rs3218536 A/G and RAD51 135G/C Gene Polymorphisms and Colorectal Cancer Risk: A Meta-Analysis PMID: 28749109 Ref: Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. PMID: 28936799 Ref: Improved chemoradiation treatment using trifluridine in human colorectal cancer cells in vitro. PMID: 29024630 Ref: Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability. PMID: 29156796 |
Ref: Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein. PMID: 29061656 Ref: Interaction between RAD51 and MCM Complex Is Essential for RAD51 Foci Forming in Colon Cancer HCT116 Cells. PMID: 29534671 Ref: RAD51 135G>C polymorphism and risk of sporadic colorectal cancer in Iranian population. PMID: 29893328 Ref: Repurposing of mTOR Complex inhibitors Attenuates MCL-1 and sensitizes to PARP inhibition. PMID: 30201826 Ref: Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy. PMID: 30289394 Ref: Polymorphism RAD51 172G > T in Serbian patients with colorectal cancer. PMID: 30358196 Ref: Retraction: Overexpression of Rad51 Predicts Poor Prognosis in Colorectal Cancer: Our Experience with 54 Patients. PMID: 30383790 |