Primary Site >> Liver Cancer

Gene >> PTTG1

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Ref: Overexpression of pituitary tumor-transforming gene-1 in hepatocellular carcinoma.
PMID: 16608036
Ref: Overexpression of pituitary tumor transforming gene 1 in HCC is associated with angiogenesis and poor prognosis.
PMID: 16628605
Ref: Adenovirus-mediated transfer of siRNA against PTTG1 inhibits liver cancer cell growth in vitro and in vivo.
PMID: 16628636
 Ref: Thyroid hormone receptors suppress pituitary tumor transforming gene 1 activity in hepatoma.
PMID: 18339849
 Ref: The basal body gene, RPGRIP1L, is a candidate tumour suppressor gene in human hepatocellular carcinoma.
PMID: 19410446
 Ref: Tumor suppressor activity of KLF6 mediated by downregulation of the PTTG1 oncogene.
PMID: 20116377
Ref: Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and degradation.
PMID: 20198633
 Ref: Role of the pituitary tumor transforming gene 1 in the progression of hepatocellular carcinoma.
PMID: 21099350
 Ref: Hepatitis B virus mRNA-mediated miR-122 inhibition upregulates PTTG1-binding protein, which promotes hepatocellular carcinoma tumor growth and cell invasion.
PMID: 23221562
 Ref: A Aconitum coreanum polysaccharide fraction induces apoptosis of hepatocellular carcinoma (HCC) cells via pituitary tumor transforming gene 1 (PTTG1)-mediated suppression of the P13K/Akt and activation of p38 MAPK signaling pathway and displays antitumor
PMID: 25874498
 Ref: Berberine regulates the protein expression of multiple tumorigenesis-related genes in hepatocellular carcinoma cell lines.
PMID: 28572744
Ref: Targeting TPX2 Suppresses the Tumorigenesis of Hepatocellular Carcinoma Cells Resulting in Arrested Mitotic Phase Progression and Increased Genomic Instability.
PMID: 28638452
 Ref: Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells.
PMID: 29606879
Ref: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma.
PMID: 29803224