Primary Site >> Liver Cancer
Gene >> PTPN11
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Ref: Isolation of a distinct class of gain-of-function SHP-2 mutants with oncogenic RAS-like transforming activity from solid tumors. PMID: 18223690 |
Ref: Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. PMID: 21575863 |
Ref: The tumor suppressor role of Src homology phosphotyrosine phosphatase 2 in hepatocellular carcinoma. PMID: 22228034 |
Ref: Functional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populations. PMID: 25198338 |
Ref: Shp2 SUMOylation promotes ERK activation and hepatocellular carcinoma development. PMID: 25823821 Ref: PTPN11/Shp2 overexpression enhances liver cancer progression and predicts poor prognosis of patients. PMID: 25865556 Ref: Functions of Shp2 in cancer. PMID: 26088100 |
Ref: Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells. PMID: 27974211 |
Ref: Tanshinone IIA induced cell death via miR30b-p53-PTPN11/SHP2 signaling pathway in human hepatocellular carcinoma cells. PMID: 27894814 Ref: SHP2 is induced by the HBx-NF-kappaB pathway and contributes to fibrosis during human early hepatocellular carcinoma development. PMID: 28460481 Ref: miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma. PMID: 28750679 Ref: Dietary quercetin potentiates the antiproliferative effect of interferon-alpha in hepatocellular carcinoma cells through activation of JAK/STAT pathway signaling by inhibition of SHP2 phosphatase. PMID: 29371942 |
Ref: Maintenance of stemness by miR-589-5p in hepatocellular carcinoma cells promotes chemoresistance via STAT3 signaling. PMID: 29196128 Ref: Shp2 deletion in hepatocytes suppresses hepatocarcinogenesis driven by oncogenic beta-Catenin, PIK3CA and MET. PMID: 29505847 |