Primary Site >> Esophagus Cancer
Gene >> PTGS2
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Ref: Cyclooxygenase-2 expression in human esophageal carcinoma. PMID: 9892207 Ref: Expression of cyclooxygenase-2 in human squamous cell carcinoma of the esophagus; an immunohistochemical survey. PMID: 10226539 |
Ref: Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by JTE-522, a selective COX-2 inhibitor. PMID: 11285187 Ref: Unusual profile and high prevalence of p53 mutations in esophageal squamous cell carcinomas from northern Iran. PMID: 11306496 Ref: Cyclooxygenase-2 expression in Barrett's esophagus. PMID: 11330414 Ref: Induction of apoptosis by cyclo-oxygenase-2 inhibitor NS398 through a cytochrome C-dependent pathway in esophageal cancer cells. PMID: 11410869 Ref: [A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions]. PMID: 11783060 |
Ref: Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. PMID: 11821953 Ref: Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. PMID: 11989839 Ref: Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus. PMID: 12055587 Ref: Does chemoprevention of Barrett's esophagus using acid suppression and/or COX-2 inhibition prevent neoplastic progression? PMID: 12478242 |
Ref: 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis in gastric cancer. PMID: 12584173 Ref: Expression of cyclo-oxygenase-2 is correlated with high intratumoral microvessel density and low apoptotic index in human esophageal squamous cell carcinomas. PMID: 12596063 Ref: Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells. PMID: 12822514 Ref: The deregulation of arachidonic acid metabolism-related genes in human esophageal squamous cell carcinoma. PMID: 12845669 Ref: Immunohistochemical analysis of cyclooxygenase-2 expression in premalignant and malignant esophageal glandular and squamous lesions in Cixian, China. PMID: 12893070 Ref: Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer. PMID: 12902863 Ref: COX-2 inhibitors as radiation sensitizers for upper GI tract cancers: esophagus, stomach, and pancreas. PMID: 12902867 Ref: Clinicopathologic significance of cyclooxygenase-2 overexpression in esophageal squamous cell carcinoma. PMID: 12963227 Ref: COX-2 inhibition in esophagitis, Barrett's esophagus and esophageal cancer. PMID: 14552327 Ref: [Cyclooxygenase-2 expression in esophageal cancer cells and induction by mitomycin C]. PMID: 14633464 |
Ref: Phenotypic differences between esophageal and gastric intestinal metaplasia. PMID: 14631367 Ref: Over-expression of gastrin-releasing peptide in human esophageal squamous cell carcinomas. PMID: 14764456 Ref: Recent results in understanding molecular pathways in the medical treatment of esophageal and gastric cancer. PMID: 15007244 Ref: Production of prostaglandinE2 via bile acid is enhanced by trypsin and acid in normal human esophageal epithelial cells. PMID: 15102519 Ref: Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. PMID: 15151617 Ref: Prognostic significance of vascular endothelial growth factor and cyclooxygenase 2 expression in patients receiving preoperative chemoradiation for esophageal cancer. PMID: 15173710 Ref: Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas. PMID: 15259059 Ref: The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation. PMID: 15375172 Ref: Cisplatin, fluorouracil, celecoxib, and RT in resectable esophageal cancer: preliminary results. PMID: 15685829 |
Ref: Prognostic role of cyclooxygenase-2 in neoadjuvant-treated patients with squamous cell carcinoma of the esophagus. PMID: 15856454 Ref: Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma. PMID: 15978332 Ref: Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer. PMID: 16083713 Ref: Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2. PMID: 16299228 Ref: High cyclooxygenase-2 expression following neoadjuvant radiochemotherapy is associated with minor histopathologic response and poor prognosis in esophageal cancer. PMID: 16322294 Ref: Neoadjuvant selective COX-2 inhibition down-regulates important oncogenic pathways in patients with esophageal adenocarcinoma. PMID: 16327494 |
Ref: Effect of acid suppression on molecular predictors for esophageal cancer. PMID: 16492917 Ref: Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice. PMID: 16543248 Ref: Transcriptional activation of cyclooxygenase-2 by tumor suppressor p53 requires nuclear factor-kappaB. PMID: 16682957 Ref: Black raspberries inhibit N-nitrosomethylbenzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. PMID: 16777990 Ref: Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. PMID: 16800771 Ref: A multiplex tissue immunoblotting assay for proteomic profiling: a pilot study of the normal to tumor transition of esophageal squamous cell carcinoma. PMID: 16835344 Ref: RRIG1 mediates effects of retinoic acid receptor beta2 on tumor cell growth and gene expression through binding to and inhibition of RhoA. PMID: 16849557 Ref: The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach. PMID: 16938519 |
Ref: COX-2, CDX2, and CDC2 immunohistochemical assessment for dysplasia-carcinoma progression in Barrett's esophagus. PMID: 17307036 Ref: Tumor-suppressive effect of retinoid receptor-induced gene-1 (RRIG1) in esophageal cancer. PMID: 17308098 Ref: Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. PMID: 17405999 Ref: Chemoprevention of esophageal squamous cell carcinoma. PMID: 17475300 Ref: Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. PMID: 17511025 Ref: Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture. PMID: 17615180 Ref: Expression of p53, p16 and cyclooxygenase-2 in esophageal cancer with tissue microarray. PMID: 17650224 Ref: [Expression and clinical significance of COX-2, p-Stat3, and p-Stat5 in esophageal carcinoma]. PMID: 17672932 |
Ref: Cyclooxygenase-2 expression is related to prognosis in patients with esophageal squamous cell carcinoma. PMID: 17553653 Ref: The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo. PMID: 18058818 Ref: Interplay between oncoproteins and antioxidant enzymes in esophageal carcinoma treated without and with chemoradiotherapy: a prospective study. PMID: 18207033 Ref: Mechanism of growth inhibitory effects of cyclooxygenase-2 inhibitor-NS398 on cancer cells. PMID: 18443952 Ref: Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway. PMID: 18452159 Ref: COX-2 (PTGS2) gene methylation in epithelial, subepithelial lymphocyte and stromal tissue compartments in a spectrum of esophageal squamous neoplasia. PMID: 18632220 |
Ref: Isolation and identification of cancer stem-like cells in esophageal carcinoma cell lines. PMID: 18680391 Ref: Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. PMID: 19111725 Ref: NS-398 induces apoptosis in human esophageal cancer cells through inhibition of NF-kappaB downstream regulation of cyclooxygenase-2. PMID: 19160097 Ref: Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. PMID: 19258542 Ref: Identification of a new broad-spectrum CD8+ T cell epitope from over-expressed antigen COX-2 in esophageal carcinoma. PMID: 19423214 Ref: Functional polymorphisms of cyclooxygenase-2 (COX-2) gene and risk for esophageal squmaous cell carcinoma. PMID: 19428370 Ref: Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma. PMID: 19630103 Ref: Immunohistochemical analysis of selected molecular markers in esophagus precancerous, adenocarcinoma and squamous cell carcinoma in Iranian subjects. PMID: 19679052 Ref: The relationship between cyclooxygenase-2, CD44v6, and nm23H1 in esophageal squamous cell carcinoma. PMID: 19816074 |
Ref: Effects of the inhibition of cyclooxygenase-2 on human esophageal cancer cells: inhibition of cell proliferation and induction of apoptosis. PMID: 19633925 Ref: -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies. PMID: 19669667 Ref: [Correlation of cyclooxygenase 2 expression with microlymphatic density and its clinical significance]. PMID: 20878581 Ref: Expression characteristics of heparanase in colon carcinoma and its close relationship with cyclooxygenase-2 and angiogenesis. PMID: 21443112 |
Ref: Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. PMID: 20857495 Ref: Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation. PMID: 21177414 Ref: Zinc supplementation suppresses 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis. PMID: 21245412 Ref: Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. PMID: 21304218 |
Ref: Randomized phase II trial of lyophilized strawberries in patients with dysplastic precancerous lesions of the esophagus. PMID: 22135048 Ref: Suppression of esophageal cancer cell growth using curcumin, (-)-epigallocatechin-3-gallate and lovastatin. PMID: 22253518 Ref: Expression of COX2 and p53 in Rat Esophageal Cancer Induced by Reflux of Duodenal Contents. PMID: 22272378 |
Ref: Inhibition of farnesoid X receptor controls esophageal cancer cell growth in vitro and in nude mouse xenografts. PMID: 23280144 Ref: COX-2 overexpression Induced by gene transfer reduces sensitivity of TE13 esophageal carcinoma cells to 5-fluorouracil and cisplatin. PMID: 23393346 Ref: OSU-03012, a non-Cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway. PMID: 23652278 Ref: Comparable molecular alterations in 4-nitroquinoline 1-oxide-induced oral and esophageal cancer in mice and in human esophageal cancer, associated with poor prognosis of patients. PMID: 23812217 |
Ref: Impact of non-steroidal anti-inflammatory drugs on gastrointestinal cancers: current state-of-the science. PMID: 24021750 Ref: Targeted therapies in metastatic esophageal cancer: advances over the past decade. PMID: 24582516 Ref: Role of chemoprophylaxis with either NSAIDs or statins in patients with Barrett's esophagus. PMID: 24605249 Ref: Association of single nucleotide polymorphisms in the prostaglandin-endoperoxide synthase 2 (PTGS2) and phospholipase A(2) group IIA (PLA2G2A) genes with susceptibility to esophageal squamous cell carcinoma. PMID: 24641411 Ref: Functional expression of TLR9 in esophageal cancer. PMID: 24647486 Ref: Effects of bile acids on cyclooxygenase-2 expression in a rat model of duodenoesophageal anastomosis. PMID: 24914375 Ref: Amiloride and guggulsterone suppression of esophageal cancer cell growth in vitro and in nude mouse xenografts. PMID: 24999355 Ref: The -765G>C polymorphism in the cyclooxygenase-2 gene and digestive system cancer: a meta-analysis. PMID: 25339021 Ref: Overexpression of phospholipase A2 Group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression. PMID: 25422234 |
Ref: Coexpression of COX-2 and iNOS in Angiogenesis of Superficial Esophageal Squamous Cell Carcinoma. PMID: 25875558 Ref: Knockdown of zinc transporter ZIP5 (SLC39A5) expression significantly inhibits human esophageal cancer progression. PMID: 26133979 |
Ref: Factors regulating nuclear factor-kappa B activation in esophageal cancer cells: Role of bile acids and acid. PMID: 27072265 Ref: Neoadjuvant irinotecan, cisplatin, and concurrent radiation therapy with celecoxib for patients with locally advanced esophageal cancer. PMID: 27412386 Ref: Knockdown of Zinc Transporter ZIP5 by RNA Interference Inhibits Esophageal Cancer Growth In Vivo. PMID: 27458102 |
Ref: Anti-cancer Effects of a Novel Quinoline Derivative 83b1 on Human Esophageal Squamous Cell Carcinoma through Down-Regulation of COX-2 mRNA and PGE2. PMID: 27456944 Ref: The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis. PMID: 28652771 Ref: Expression of methylation-modulated tumor-related genes in endoscopically resected early esophageal squamous neoplasia. PMID: 28693228 Ref: Cytotoxicity of replication-competent adenoviruses powered by an exogenous regulatory region is not linearly correlated with the viral infectivity/gene expression or with the E1A-activating ability but is associated with the p53 genotypes. PMID: 28874135 Ref: Predictive biomarkers for response of esophageal cancer to chemo(radio)therapy: A systematic review and meta-analysis. PMID: 29113666 |
Ref: Expression profiles of Annexin A1, formylated peptide receptors and cyclooxigenase-2 in gastroesophageal inflammations and neoplasias. PMID: 29254791 Ref: Glucose-regulated protein 94 mediates progression and metastasis of esophageal squamous cell carcinoma via mitochondrial function and the NF-kB/COX-2/VEGF axis. PMID: 29507700 Ref: Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province. PMID: 29893307 Ref: Gproteincoupled receptor 120 regulates the development and progression of human esophageal cancer. PMID: 29901155 |