Primary Site >> Colorectal Cancer
Gene >> PTGS2
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Ref: Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. PMID: 7926468 |
Ref: Expression of cyclooxygenase-1 and -2 in human colorectal cancer. PMID: 7641194 Ref: Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. PMID: 7780968 |
Ref: Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. PMID: 8613017 Ref: G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. PMID: 8631005 Ref: Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. PMID: 8643486 Ref: Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis. PMID: 8653697 Ref: Elevated cyclooxygenase-2 levels in Min mouse adenomas. PMID: 8831610 Ref: Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. PMID: 8840961 Ref: The role of cyclic AMP and oxygen intermediates in the inhibition of cellular immunity in cancer. PMID: 8917629 |
Ref: Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. PMID: 9012840 Ref: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. PMID: 9096394 Ref: Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells. PMID: 9099957 Ref: Expression of cyclooxygenase-2 in human gastric carcinoma. PMID: 9102213 Ref: Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. PMID: 9151799 Ref: Colorectal cancer and nonsteroidal anti-inflammatory drugs. PMID: 9160111 Ref: Cyclo-oxygenase and colon cancer: clues to the aspirin effect? PMID: 9240630 Ref: [Molecular etiology of colorectal carcinogenesis, clinical manifestations and therapy]. PMID: 9244653 Ref: [Multiple roles of inducible cyclooxygenase-2 and its selective inhibitors]. PMID: 9253772 Ref: Dietary fat and colon cancer: modulation of cyclooxygenase-2 by types and amount of dietary fat during the postinitiation stage of colon carcinogenesis. PMID: 9270014 Ref: Experimental models of gene-environment interaction for cancer chemoprevention studies. PMID: 9327228 Ref: A selective cyclooxygenase 2 inhibitor suppresses the growth of H-ras-transformed rat intestinal epithelial cells. PMID: 9394727 Ref: Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor, in Min mice. PMID: 9473726 Ref: Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression. PMID: 9815550 |
Ref: Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis. PMID: 9458081 Ref: Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. PMID: 9458096 Ref: Cyclooxygenase-2-selective antagonists do not inhibit growth of colorectal carcinoma cell lines. PMID: 9464487 Ref: The nuclear eicosanoid receptor, PPARgamma, is aberrantly expressed in colonic cancers. PMID: 9472692 Ref: Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. PMID: 9521170 Ref: Chemopreventive effects of NSAIDs against colorectal cancer: regulation of apoptosis and mitosis by COX-1 and COX-2. PMID: 9589912 Ref: Aspirin-like molecules that covalently inactivate cyclooxygenase-2. PMID: 9596581 Ref: Cyclooxygenases 1 and 2. PMID: 9597150 Ref: Antioxidants reduce cyclooxygenase-2 expression, prostaglandin production, and proliferation in colorectal cancer cells. PMID: 9622066 Ref: Use and safety of aspirin in the chemoprevention of colorectal cancer. PMID: 9648425 Ref: Barrett's oesophagus, oesophageal cancer and colon cancer: an explanation of the association and cancer chemopreventive potential of non-steroidal anti-inflammatory drugs. PMID: 9696927 Ref: Cyclooxygenase-2 expression in human adenocarcinoma cell line HT29 cl.19A. PMID: 9703885 Ref: Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. PMID: 9734399 Ref: Increased expression of cyclooxygenase-2 to -1 in human colorectal cancers and adenomas, but not in hyperplastic polyps. PMID: 9739782 Ref: Size- and invasion-dependent increase in cyclooxygenase 2 levels in human colorectal carcinomas. PMID: 9809985 Ref: The inducible prostaglandin biosynthetic enzyme, cyclooxygenase 2, is not mutated in patients with attenuated adenomatous polyposis coli. PMID: 9809998 Ref: Rectal cancer after sulindac therapy for a sporadic adenomatous colonic polyp. PMID: 9820411 Ref: Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators. PMID: 9822550 Ref: COX-2 and colon cancer. PMID: 9831333 Ref: Expression of cyclooxygenase-2 protein in gastric adenocarcinoma. PMID: 9846504 Ref: Reduced COX-2 protein in colorectal cancer with defective mismatch repair. PMID: 9850081 Ref: Induction of apoptotic DNA fragmentation by nonsteroidal anti-inflammatory drugs in cultured rat gastric mucosal cells. PMID: 9851595 Ref: Gene expression of cyclooxygenase-2, group II and cytosolic phospholipase A2 in human colorectal cancer. PMID: 9858896 Ref: Meloxicam inhibits the growth of colorectal cancer cells. PMID: 9886578 |
Ref: Regulation of cyclooxygenase-2 pathway by HER2 receptor. PMID: 9927187 Ref: Coordinate regulation of cyclooxygenase-2 and TGF-beta1 in replication error-positive colon cancer and azoxymethane-induced rat colonic tumors. PMID: 10069452 Ref: Nonsteroidal anti-inflammatory drugs may prevent colon cancer through suppression of hepatocyte growth factor expression. PMID: 10082276 Ref: Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice. PMID: 10188882 Ref: Role of cyclooxygenase-1 and -2 in health and disease. PMID: 10193997 Ref: Differential expression of matrilysin and cyclooxygenase-2 in intestinal and colorectal neoplasms. PMID: 10204802 Ref: Growth stimulation and induction of epidermal growth factor receptor by overexpression of cyclooxygenases 1 and 2 in human colon carcinoma cells. PMID: 10216286 Ref: Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. PMID: 10223193 Ref: Cyclooxygenase-2 expression in hepatocellular carcinoma. PMID: 10228831 Ref: Metabolic targets of cancer chemoprevention: interruption of tumor development by inhibitors of arachidonic acid metabolism. PMID: 10337718 Ref: [Non-steroidal anti-inflammatory drugs and cyclooxygenase-2 selectivity in gastroenterology]. PMID: 10348929 Ref: The clinical potential of cyclooxygenase-2-specific inhibitors. PMID: 10390128 Ref: Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers. PMID: 10419916 Ref: Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. PMID: 10433483 Ref: Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. PMID: 10449029 Ref: Induction of prostaglandin G/H synthase-2 in a canine model of spontaneous prostatic adenocarcinoma. PMID: 10451445 Ref: Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. PMID: 10471521 Ref: The prevention of colorectal cancer by aspirin use. PMID: 10472428 Ref: High expression of cyclooxygenase-2 in macrophages of human colonic adenoma. PMID: 10508481 Ref: Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer. PMID: 10515422 Ref: The relationship between cyclooxygenase-2 expression and colorectal cancer. PMID: 10517428 Ref: Differential expression of cyclooxygenase 2 in human colorectal cancer. PMID: 10517910 Ref: Chemoprevention of colorectal cancer through inhibition of cyclooxygenase-2. PMID: 10528897 Ref: Introduction of full-length APC modulates cyclooxygenase-2 expression in HT-29 human colorectal carcinoma cells at the translational level. PMID: 10545404 Ref: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex. PMID: 10557090 Ref: Overexpression of cyclooxygenase-2 induces cell cycle arrest. Evidence for a prostaglandin-independent mechanism. PMID: 10567385 Ref: Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma. PMID: 10612291 Ref: The role of cyclooxygenases in inflammation, cancer, and development. PMID: 10630643 Ref: The molecular biology of colorectal cancer development and the associated genetic events. PMID: 10645173 Ref: Cellular localization of cyclo-oxygenase isozymes in Crohn's disease and colorectal cancer. PMID: 10647629 Ref: [Selective cyclooxygenase-2 (COX-2) inhibitors: importance and limitations]. PMID: 10667110 Ref: Cyclooxygenase-2 as a target for prevention of colorectal cancer. PMID: 11122816 Ref: COX-2 inhibitors--IBC conference. 12-13 April 1999, Coronado, CA, USA. PMID: 16127636 |
Ref: A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate. PMID: 10607736 Ref: Cyclooxygenase 2 expression is increased in the stroma of colon carcinomas from IL-10(-/-) mice. PMID: 10648462 Ref: Localization of cyclooxygenase-2 in human sporadic colorectal adenomas. PMID: 10666384 Ref: Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis. PMID: 10667579 Ref: Molecular pathology of cyclooxygenase-2 in neoplasia. PMID: 10678579 Ref: Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. PMID: 10690533 Ref: Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs. PMID: 10706128 Ref: Cyclooxygenase-2 and carcinogenesis. PMID: 10722929 Ref: Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. PMID: 10728691 Ref: The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells: evidence of different mechanisms of action. PMID: 10738133 Ref: Cyclooxygenase-2, a colorectal cancer nonsteroidal anti-inflammatory drug target, is regulated by c-MYB. PMID: 10766162 Ref: Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. PMID: 10766173 Ref: Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3'-untranslated region. PMID: 10766797 Ref: Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. PMID: 10772828 Ref: Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. PMID: 10783317 Ref: Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure. PMID: 10783318 Ref: Review article: cyclooxygenase--a target for colon cancer prevention. PMID: 10807405 Ref: Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells. PMID: 10834941 Ref: Host cyclooxygenase-2 modulates carcinoma growth. PMID: 10841517 Ref: Cyclooxygenase-2 expression is up-regulated in transitional cell carcinoma and its preneoplastic lesions in the human urinary bladder. PMID: 10873095 Ref: Enhancement of intrinsic tumor cell radiosensitivity induced by a selective cyclooxygenase-2 inhibitor. PMID: 10873107 Ref: Cyclooxygenase-2 expression is abundant in alveolar type II cells in lung cancer-sensitive mouse strains and in premalignant lesions. PMID: 10874016 Ref: The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. PMID: 10874062 Ref: Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats. PMID: 10893436 Ref: Colon cancer: a role for cyclo-oxygenase-2-specific nonsteroidal anti-inflammatory drugs. PMID: 10917070 Ref: Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer. PMID: 10917546 Ref: Differential expression of cyclooxygenase 2 in human colorectal cancer. PMID: 10917748 Ref: Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor. PMID: 10919635 Ref: Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. PMID: 10919656 Ref: Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. PMID: 10920275 Ref: Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. PMID: 10930401 Ref: Expression of cyclooxygenase-2 in prostate carcinoma. PMID: 10931458 Ref: Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors. PMID: 10945606 Ref: Effect of prostaglandin E1 on vascular endothelial growth factor production by human macrophages and colon cancer cells. PMID: 10965822 Ref: Cyclooxygenases: structural, cellular, and molecular biology. PMID: 10966456 Ref: Intracellular unesterified arachidonic acid signals apoptosis. PMID: 11005842 Ref: The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis. PMID: 11016626 Ref: Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. PMID: 11023534 Ref: Cyclooxygenase-2: its rich diversity of roles and possible application of its selective inhibitors. PMID: 11028754 Ref: Cyclooxygenase-2 expression correlates with tumor neovascularization and prognosis in human colorectal carcinoma patients. PMID: 11051257 Ref: Induction of prostaglandin endoperoxide synthase 2 by mitogen-activated protein kinase cascades. PMID: 11085935 Ref: Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer. PMID: 11087869 Ref: [Non-steroidal anti-inflammatory agents with selective inhibitory activity on cyclooxygenase-2. Interest and future prospects]. PMID: 11109595 Ref: Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells. PMID: 11118042 Ref: 15-Lipoxygenase-1 mediates nonsteroidal anti-inflammatory drug-induced apoptosis independently of cyclooxygenase-2 in colon cancer cells. PMID: 11156377 Ref: Non-steroidal anti-inflammatory drugs with different cyclooxygenase inhibitory profiles that prevent aberrant crypt foci formation but vary in acute gastrotoxicity in a rat model. PMID: 11197048 Ref: Induction of apoptosis by JTE-522, a specific cyclooxygenase-2 inhibitor, in human gastric cancer cell lines. PMID: 11205258 Ref: Cyclooxygenase-2 expression in colorectal cancer liver metastases. PMID: 11206834 Ref: Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. PMID: 11228540 Ref: Colorectal cancer and non-steroidal anti-inflammatory drugs. PMID: 11324434 |
Ref: Specific inhibition of cyclooxygenase-2 results in inhibition of proliferation of oral cancer cell lines via suppression of prostaglandin E2 production. PMID: 11140899 Ref: Colonic luminal contents induce cyclooxygenase 2 transcription in human colon carcinoma cells. PMID: 11159881 Ref: Nonsteroidal anti-inflammatory drugs and the gastrointestinal tract. Extent, mode, and dose dependence of anticancer effects. PMID: 11166002 Ref: The retinoid fenretinide inhibits proliferation and downregulates cyclooxygenase-2 gene expression in human colon adenocarcinoma cell lines. PMID: 11166911 Ref: Clinicopathologic association of cyclooxygenase 1 and cyclooxygenase 2 expression in gastric adenocarcinoma. PMID: 11176123 Ref: Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. PMID: 11221833 Ref: Expression of cyclooxygenase-2 in human gastric adenomas and adenocarcinomas. PMID: 11223821 Ref: Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. PMID: 11245490 Ref: PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. PMID: 11274170 Ref: Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. PMID: 11275997 Ref: Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 11292836 Ref: Non-steroidal anti-inflammatory drugs with activity against either cyclooxygenase 1 or cyclooxygenase 2 inhibit colorectal cancer in a DMH rodent model by inducing apoptosis and inhibiting cell proliferation. PMID: 11302965 Ref: Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS398 through a cytochrome c-dependent pathway. PMID: 11309352 Ref: Testing for colon neoplasia susceptibility variants at the human COX2 locus. PMID: 11309440 Ref: Epithelial cyclooxygenase-2 expression: a model for pathogenesis of colon cancer. PMID: 11319881 Ref: Cyclooxygenase-2 expression in Barrett's esophagus. PMID: 11330414 Ref: Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis. PMID: 11336575 Ref: Expression of cyclooxygenase-2 in patients with bladder carcinoma. PMID: 11342898 Ref: Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: relationship with drug levels. PMID: 11350917 Ref: Rat colorectal tumours treated with a range of non-steroidal anti-inflammatory drugs show altered cyclooxygenase-2 and cyclooxygenase-1 splice variant mRNA expression levels. PMID: 11375891 Ref: Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal carcinoma growth. PMID: 11375952 Ref: Enhanced expression of cyclooxygenase-2 and nuclear beta-catenin are related to mutations in the APC gene in human colorectal cancer. PMID: 11396184 Ref: Cyclooxygenase-2: a target for the prevention and treatment of breast cancer. PMID: 11397667 Ref: Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas. PMID: 11407522 Ref: Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. PMID: 11412039 Ref: Cyclooxygenase-2: a novel target for cancer chemotherapy? PMID: 11469677 Ref: Familiar drugs may prevent cancer. PMID: 11470927 Ref: Detection of differentially expressed genes in human colon carcinoma cells treated with a selective COX-2 inhibitor. PMID: 11494140 Ref: [Clinical application of cyclooxygenase-2 inhibitors]. PMID: 11503270 Ref: Suppression of intestinal polyps in Msh2-deficient and non-Msh2-deficient multiple intestinal neoplasia mice by a specific cyclooxygenase-2 inhibitor and by a dual cyclooxygenase-1/2 inhibitor. PMID: 11507063 Ref: Lipoxygenase modulation to reverse carcinogenesis. PMID: 11522616 Ref: Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. PMID: 11532858 Ref: Cyclooxygenase-2, malondialdehyde and pyrimidopurinone adducts of deoxyguanosine in human colon cells. PMID: 11532880 Ref: Expression of prostaglandin H synthase-2 in human brain tumors. PMID: 11563634 Ref: Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. PMID: 11566484 Ref: A selective cyclooxygenase-2 inhibitor, NS-398, enhances the effect of radiation in vitro and in vivo preferentially on the cells that express cyclooxygenase-2. PMID: 11595687 Ref: Functional characterization of cyclooxygenase-2 polymorphisms. PMID: 11602656 Ref: COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib. PMID: 11606477 Ref: Molecular basis of colorectal cancer - role of gastrin and cyclooxygenase-2. PMID: 11687726 Ref: Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. PMID: 11688844 Ref: Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer. PMID: 11705852 Ref: Up-regulation of cyclooxygenase 2 gene expression correlates with tumor angiogenesis in human colorectal cancer. PMID: 11729113 Ref: [COX-2 inhibitor and colon cancer]. PMID: 11729471 Ref: Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. PMID: 11731423 Ref: Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. PMID: 11733561 Ref: Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. PMID: 11751448 Ref: Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis. PMID: 11751493 Ref: An introduction to aspirin, NSAids, and COX-2 inhibitors for the primary prevention of cardiovascular events and cancer and their potential preventive role in bladder carcinogenesis: part II. PMID: 11769882 Ref: [Specific inhibitors of cyclooxygenase-2 (COX-2): current knowledge and perspectives]. PMID: 11889908 Ref: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. PMID: 11900248 Ref: Cancer chemoprevention by dietary constituents: a tale of failure and promise. PMID: 11905754 Ref: Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives. PMID: 11991685 Ref: The molecular basis for prevention of colorectal cancer. PMID: 12445379 Ref: Genotype Frequencies of Cyclooxygenease 2 (COX2) Rare Polymorphisms for Japanese with and without Colorectal Cancer. PMID: 12718655 Ref: Cyclooxygenase-2 and antagonists in pain management. PMID: 17019141 Ref: Nonsteroidal antiinflammatory drugs, cyclooxygenase-2, and colorectal cancer prevention. PMID: 17031153 |
Ref: Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. PMID: 11782353 Ref: Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. PMID: 11782374 Ref: Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer. PMID: 11786771 Ref: Chemoprevention of colorectal cancer. PMID: 11808936 Ref: Suppression of promoter-dependent transcriptional activity of inducible nitric oxide synthase by sodium butyrate in colon cancer cells. PMID: 11825662 Ref: Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. PMID: 11857443 Ref: Cyclooxygenase-2 activity altered the cell-surface carbohydrate antigens on colon cancer cells and enhanced liver metastasis. PMID: 11888937 Ref: Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens. PMID: 11894121 Ref: Expression profile analysis of colon cancer cells in response to sulindac or aspirin. PMID: 11906190 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 Ref: Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs. PMID: 11920463 Ref: New strategies for colorectal cancer prevention and treatment. PMID: 11948369 Ref: Review article: COX-2, prostanoids and colon cancer. PMID: 11966530 Ref: The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. PMID: 11992399 Ref: Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer. PMID: 12003384 Ref: Celecoxib with chemotherapy in colorectal cancer. PMID: 12014863 Ref: Rationale and feasibility of chemoprovention of hepatocellular carcinoma by cyclooxygenase-2 inhibitors. PMID: 12024111 Ref: Group IID heparin-binding secretory phospholipase A(2) is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues. PMID: 12047378 Ref: Comparison of cyclo-oxygenase 2 expression in colorectal serrated adenomas to expression in tubular adenomas and hyperplastic polyps. PMID: 12049307 Ref: [Colorectal cancer and inhibition of cyclooxygenase-2]. PMID: 12053285 Ref: Purification and characterization of a cyclooxygenase-2 and angiogenesis suppressing factor produced by human fibroblasts. PMID: 12060668 Ref: Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report. PMID: 12074318 Ref: Studies on the development of colon-targeted delivery systems for celecoxib in the prevention of colorectal cancer. PMID: 12075826 Ref: Potential role of selective COX-2 inhibitors in cancer management. PMID: 12102578 Ref: Preoperative chemoradiation for locally advanced rectal cancer: emerging treatment strategies. PMID: 12109806 Ref: Cyclooxygenase-2 overexpression in colorectal cancer is associated with non-polypoid growth. PMID: 12110643 Ref: Inhibitory effect of a selective cyclooxygenase-2 inhibitor on liver metastasis of colon cancer. PMID: 12124799 Ref: Reduction of intestinal neoplasia with adenomatous polyposis coli gene replacement and COX-2 inhibition is additive. PMID: 12127122 Ref: A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. PMID: 12138405 Ref: Chemoprevention in colorectal neoplasias: what is practical and feasible? PMID: 12145422 Ref: [Recent notions on intestinal cancerogenesis, their implications in genetic risk screening and preventive action of non-steroid anti-inflammatory agents]. PMID: 12145848 Ref: Expression of COX-2 and Wnt pathway genes in adenomas of familial adenomatous polyposis patients treated with meloxicam. PMID: 12174906 Ref: COX-2 selective inhibition reverses the trophic properties of gastrin in colorectal cancer. PMID: 12189559 Ref: Cyclooxygenase-2 inhibition augments the hepatic antitumor effect of oral Salmonella typhimurium in a model of mouse metastatic colon cancer. PMID: 12195185 Ref: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. PMID: 12208739 Ref: Gastrin stimulates cyclooxygenase-2 expression in intestinal epithelial cells through multiple signaling pathways. Evidence for involvement of ERK5 kinase and transactivation of the epidermal growth factor receptor. PMID: 12239223 Ref: Progastrin and cyclooxygenase-2 in colorectal cancer. PMID: 12353842 Ref: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways. PMID: 12360401 Ref: Calcium-independent phospholipase A2 through arachidonic acid mobilization is involved in Caco-2 cell growth. PMID: 12384982 Ref: Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. PMID: 12405290 Ref: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. PMID: 12414664 Ref: The effects of acetylsalicylic acid on proliferation, apoptosis, and invasion of cyclooxygenase-2 negative colon cancer cells. PMID: 12423325 Ref: Selenomethionine inhibits growth and suppresses cyclooxygenase-2 (COX-2) protein expression in human colon cancer cell lines. PMID: 12432249 Ref: Cyclooxygenases and colon cancer. PMID: 12432918 Ref: Prostaglandin H synthase 2 variant (Val511Ala) in African Americans may reduce the risk for colorectal neoplasia. PMID: 12433707 Ref: Human colorectal adenomas demonstrate a size-dependent increase in epithelial cyclooxygenase-2 expression. PMID: 12434411 Ref: Anticancer activity of Scutellaria baicalensis and its potential mechanism. PMID: 12470437 Ref: Role of cyclooxygenase-2 in breast cancer. PMID: 12472107 Ref: New avenues for the prevention of colorectal cancer: targeting cyclo-oxygenase-2 activity. PMID: 12473300 Ref: COX-2, NSAIDs and human neoplasia. Part I: Colorectal neoplasms. PMID: 12494894 Ref: Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. PMID: 12496057 Ref: Effect of celecoxib on capecitabine-induced hand-foot syndrome and antitumor activity. PMID: 12520638 Ref: Expression of cyclooxygenase-2 protein in colorectal carcinomas. PMID: 12622426 Ref: Inhibition of ultraviolet light B-induced cutaneous inflammation by a specific cyclooxygenase-2 inhibitor. PMID: 12664569 Ref: Modulation of cyclooxygenase-2 expression by APC in HT-29 human colorectal carcinoma cells. PMID: 12664576 Ref: The role of cyclooxygenase-2 in the pathogenesis of skin cancer. PMID: 12847753 |
Ref: Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. PMID: 12480928 Ref: Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study. PMID: 12519636 Ref: Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. PMID: 12523457 Ref: Cyclooxygenase-2 expression and prostanoid biogenesis reflect clinical phenotype in human colorectal fibroblast strains. PMID: 12543811 Ref: Increased cyclooxygenase-2 expression in large flat colorectal tumors (laterally spreading tumors). PMID: 12560924 Ref: Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice. PMID: 12566300 Ref: Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. PMID: 12566320 Ref: The structure of mammalian cyclooxygenases. PMID: 12574066 Ref: Inverse association between phospholipase A2 and COX-2 expression during mouse colon tumorigenesis. PMID: 12584182 Ref: Induction of cyclooxygenase-2 in monocyte/macrophage by mucins secreted from colon cancer cells. PMID: 12598658 Ref: [Relationship between carcinoembryonic antigen and cyclooxygenase 2 expression and colorectal cancer]. PMID: 12600292 Ref: Regulation of leukotriene-dependent induction of cyclooxygenase-2 and Bcl-2. PMID: 12604350 Ref: Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. PMID: 12615711 Ref: Cyclooxygenase-2: from arthritis treatment to new indications for the prevention and treatment of cancer. PMID: 12629931 Ref: Inhibited proliferation of cyclooxygenase-2 expressing human hepatoma cells by NS-398, a selective COX-2 inhibitor. PMID: 12632065 Ref: The potential for a selective cyclooxygenase-2 inhibitor in the prevention of liver metastasis in human colorectal cancer. PMID: 12680220 Ref: Combination of a selective cyclooxygenase-2 inhibitor with epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 and protein kinase A antisense causes cooperative antitumor and antiangiogenic effect. PMID: 12684433 Ref: Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. PMID: 12702555 Ref: [Epidemiological studies for evaluating the role of cyclooxygenase in chemoprevention of malignant tumors]. PMID: 12705063 Ref: Nitric oxide induces cyclooxygenase expression and inhibits cell growth in colon cancer cell lines. PMID: 12727790 Ref: Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. PMID: 12727794 Ref: Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis. 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PMID: 15789623 Ref: E1A-F is overexpressed early in human colorectal neoplasia and associated with cyclooxygenase-2 and matrix metalloproteinase-7. PMID: 15800927 Ref: Cytoplasmic phospholipase A2 deletion enhances colon tumorigenesis. PMID: 15805260 Ref: A molecular/epidemiologic analysis of expression of cyclooxygenases 1 and 2, use of nonsteroidal antiinflammatory drugs, and risk of colorectal adenoma. PMID: 15807932 Ref: Selenium supplementation may increase the efficacy of cetuximab in metastatic colorectal cancer patients. PMID: 15823708 Ref: Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells. PMID: 15841493 Ref: Rofecoxib does not inhibit aberrant crypt foci formation but inhibits later steps in the development of experimental colorectal cancer: rofecoxib in experimental colon cancer. PMID: 15841716 Ref: [Study on inhibitory effect of matrine on cyclooxygenase-2 expression in colon cancer HT-29 cell line]. PMID: 15842147 Ref: Intratumoral COX-2 gene expression is a predictive factor for colorectal cancer response to fluoropyrimidine-based chemotherapy. PMID: 15867236 Ref: Supra-additive growth inhibition by a celecoxib analogue and carboxyamido-triazole is primarily mediated through apoptosis. PMID: 15867384 Ref: Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance. PMID: 15878334 Ref: Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins. PMID: 15883203 Ref: Gene-specific methylation and subsequent risk of colorectal adenomas among participants of the polyp prevention trial. PMID: 15894675 Ref: Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. 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PMID: 15993407 Ref: Cyclooxygenase-2 expression in human colorectal cancer is unrelated to overall patient survival. PMID: 16000571 Ref: Combination of cyclooxygenase-2 inhibitors and oxaliplatin increases the growth inhibition and death in human colon cancer cells. PMID: 16004971 Ref: Autocrine vascular endothelial growth factor/vascular endothelial growth factor receptor-2 growth pathway represents a cyclooxygenase-2-independent target for the cyclooxygenase-2 inhibitor NS-398 in colon cancer cells. PMID: 16015035 Ref: Prostaglandin E2 activates mitogen-activated protein kinase/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. PMID: 16024629 Ref: Inhibition of azoxymethane-induced aberrant crypt foci in rat by diphenylmethyl selenocyanate through downregulation of COX-2 and modulation of glutathione-S-transferase and lipid peroxidation. PMID: 16034162 Ref: Prospects in NSAID-derived chemoprevention of colorectal cancer. PMID: 16042570 Ref: Expression of apoptosis related proteins during malignant progression in chronic ulcerative colitis. PMID: 16049281 Ref: COX-2 expression during early lung squamous cell carcinoma oncogenesis. PMID: 16055866 Ref: Oncogenic potential of MEK1 in rat intestinal epithelial cells is mediated via cyclooxygenase-2. PMID: 16083714 Ref: A phase II trial of irinotecan, 5-fluorouracil and leucovorin combined with celecoxib and glutamine as first-line therapy for advanced colorectal cancer. PMID: 16088234 Ref: In vitro effects on polydextrose by colonic bacteria and caco-2 cell cyclooxygenase gene expression. PMID: 16091009 Ref: Nuclear factor kappaB (NFkappaB) and cyclooxygenase-2 (Cox-2) expression in the irradiated colorectum is associated with subsequent histopathological changes. PMID: 16099597 Ref: The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2. PMID: 16099783 Ref: Potential use of COX-2-aromatase inhibitor combinations in breast cancer. PMID: 16100520 Ref: Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. PMID: 16119982 Ref: Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells. PMID: 16127422 Ref: Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. PMID: 16140976 Ref: Prognostic importance of COX-2 expression in patients with colorectal cancer. PMID: 16164044 Ref: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells. PMID: 16166323 Ref: Celecoxib and curcumin synergistically inhibit the growth of colorectal cancer cells. PMID: 16166455 Ref: Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors. PMID: 16174078 Ref: Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds. PMID: 16177193 Ref: Significance of Cox-2 expression in rectal cancers with or without preoperative radiotherapy. PMID: 16199309 Ref: The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. PMID: 16203768 Ref: Cyclooxygenase-2 inhibition prevents colorectal cancer: from the bench to the bed side. PMID: 16210875 Ref: Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. PMID: 16213893 Ref: Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells. PMID: 16237757 Ref: Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2. PMID: 16251413 Ref: Cyclooxygenase-2 inhibition in colon experimental carcinogenesis. PMID: 16266236 Ref: Tissue-specific modulation of cyclooxygenase-2 (Cox-2) expression in the uterus and the v. cava by estrogens and phytoestrogens. PMID: 16274925 Ref: Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. PMID: 16293724 Ref: Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer. PMID: 16317264 Ref: [Molecular mechanism of cyclooxygenase-2 inhibitor in inhibition of proliferation of colon cancer cells by modulating Stat5 signal transduction pathway]. PMID: 16321305 Ref: [Correlation between Stat3 signal transduction pathway and expression of cyclooxygenase-2 in colorectal cancer cells]. PMID: 16324362 Ref: Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae. PMID: 16357153 Ref: [Characteristics of colon cancer diagnosed in patients taking aspirin or warfarin]. PMID: 16371720 Ref: [Therapeutic strategies using VEGF inhibitors in colorectal cancer]. PMID: 16387667 Ref: Commentary: targeting colorectal cancer through molecular biology. PMID: 16399429 Ref: EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells. PMID: 16416603 Ref: [Cyclooxygenase-2 expression as a prognostic factor in sporadic colorectal cancer]. PMID: 16420789 Ref: [Molecular epidemiologic analysis of the levels of metalloproteases and cyclooxygenase-2 in colorectal cancer]. 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PMID: 16818642 Ref: Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer. PMID: 16820091 Ref: Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. PMID: 16821623 Ref: Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. PMID: 16835502 Ref: The involvement of nuclear factor-kappa B in cyclooxygenase-2 overexpression in murine colon cancer cells transduced with herpes simplex virus thymidine kinase gene. PMID: 16841079 Ref: 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. PMID: 16880406 Ref: [Effects of selective and non-selective cyclooxygenase-2 inhibitor on the growth of colon cancer cells]. PMID: 16909598 Ref: Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 16972245 Ref: Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. PMID: 16996805 Ref: Effects of quercetin and beta-carotene supplementation on azoxymethane-induced colon carcinogenesis and inflammatory responses in rats fed with high-fat diet rich in omega-6 fatty acids. PMID: 17012770 Ref: Host and direct antitumor effects and profound reduction in tumor metastasis with selective EP4 receptor antagonism. PMID: 17018624 Ref: Aldose reductase regulates growth factor-induced cyclooxygenase-2 expression and prostaglandin E2 production in human colon cancer cells. PMID: 17018629 Ref: Beta-Catenin stabilizes cyclooxygenase-2 mRNA by interacting with AU-rich elements of 3'-UTR. PMID: 17040897 Ref: Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells. PMID: 17047069 Ref: Effect of indomethacin on Bfl-1, WISP-1 and proliferating cell nuclear antigen in colon cancer cell line HCT116 cells. PMID: 17054584 Ref: [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis]. PMID: 17062337 Ref: Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. PMID: 17075120 Ref: Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection. PMID: 17145847 Ref: Cellular FLICE-inhibitory protein down-regulation contributes to celecoxib-induced apoptosis in human lung cancer cells. PMID: 17145853 Ref: Chemoprevention of colorectal cancer: two steps forward, one step back? PMID: 17155896 Ref: RhoA mediates cyclooxygenase-2 signaling to disrupt the formation of adherens junctions and increase cell motility. PMID: 17178865 Ref: Cyclo-oxygenase-2 over-expression is associated with human esophageal squamous cell carcinoma. PMID: 17220580 Ref: Gene expression levels of epidermal growth factor receptor, survivin, and vascular endothelial growth factor as molecular markers of lymph node involvement in patients with locally advanced rectal cancer. PMID: 17241515 Ref: Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cells. PMID: 17341607 Ref: Tissue microarray-determined expression profiles of cyclooxygenase-2 in colorectal adenocarcinoma: association with clinicopathological parameters. PMID: 17357536 Ref: Prognostic significance of vascular endothelial growth factor and cyclooxygenase-2 in patients with rectal cancer treated with preoperative radiotherapy. 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PMID: 17178380 Ref: Anti-EGFR and ErbB-2 antibodies attenuate cyclooxygenase-2 expression and cooperatively inhibit survival of human colon cancer cells. PMID: 17189670 Ref: Vascular endothelial growth factor and cyclooxygenase-2 are overexpressed in ileal pouch-anal anastomosis. PMID: 17195901 Ref: Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. PMID: 17234795 Ref: Cyclooxygenase-2 and tumor biology. PMID: 17249380 Ref: Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene. PMID: 17258704 Ref: Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells. PMID: 17277882 Ref: Celecoxib and mucosal protection: translation from an animal model to a phase I clinical trial of celecoxib, irinotecan, and 5-fluorouracil. PMID: 17289892 Ref: Blood levels of long-chain polyunsaturated fatty acids, aspirin, and the risk of colorectal cancer. PMID: 17301265 Ref: Absence of cyclooxygenase-2 protein expression is a predictor of tumor regression in rectal cancer treated with preoperative short-term chemoradiotherapy. PMID: 17308999 Ref: Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. PMID: 17369603 Ref: Prostaglandin E2 induces the expression of IL-1alpha in colon cancer cells. PMID: 17371964 Ref: Detection of hypermethylated DNA or cyclooxygenase-2 messenger RNA in fecal samples of patients with colorectal cancer or polyps. PMID: 17378912 Ref: [Evaluation of cyclooxygenase-2 in the prediction of liver metastasis of colorectal carcinoma]. PMID: 17403293 Ref: Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells. PMID: 17437271 Ref: Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice. 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PMID: 17612052 Ref: HETEs enhance IL-1-mediated COX-2 expression via augmentation of message stability in human colonic myofibroblasts. PMID: 17640979 Ref: Involvement of cyclooxygenase-2 in the tumor site-dependent production of parathyroid hormone-related protein in colon 26 carcinoma. PMID: 17645771 Ref: Rofecoxib has different effects on chemokine production in colorectal cancer cells and tumor immune splenocytes. PMID: 17667525 Ref: Correlation of beta-catenin localization with cyclooxygenase-2 expression and CpG island methylator phenotype (CIMP) in colorectal cancer. PMID: 17710160 Ref: Reversal of expression of 15-lipoxygenase-1 to cyclooxygenase-2 is associated with development of colonic cancer. PMID: 17711445 Ref: 5-Lipoxygenase is coexpressed with Cox-2 in sporadic colorectal cancer: a correlation with advanced stage. PMID: 17762961 Ref: The effect of body weight on altered expression of nuclear receptors and cyclooxygenase-2 in human colorectal cancers. PMID: 17767717 Ref: Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. PMID: 17846040 Ref: SDX-308 and SDX-101, non-steroidal anti-inflammatory drugs, as therapeutic candidates for treating hematologic malignancies including myeloma. PMID: 17849446 Ref: Inhibitory effect of phytoglycoprotein on tumor necrosis factor-alpha and interleukin-6 at initiation stage of colon cancer in 1,2-dimethylhydrazine-treated ICR mice. PMID: 17868752 Ref: Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice. PMID: 17875695 Ref: Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. PMID: 17877615 Ref: An increased expression of cysteinyl leukotriene 2 receptor in colorectal adenocarcinomas correlates with high differentiation. PMID: 17909024 Ref: beta-catenin regulates multiple steps of RNA metabolism as revealed by the RNA aptamer in colon cancer cells. PMID: 17909039 Ref: Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. PMID: 17909047 Ref: Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. PMID: 17942926 Ref: Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. PMID: 17950073 Ref: Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer. PMID: 18055324 Ref: hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. PMID: 18214062 Ref: Convergence of genetic, nutritional and inflammatory factors in gastrointestinal cancers. PMID: 18240541 |
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PMID: 18097606 Ref: Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression. PMID: 18228100 Ref: Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. PMID: 18230181 Ref: Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer. PMID: 18247029 Ref: Effects of nimesulide, a cyclooxygenase-2 selective inhibitor, on colitis induced tumors. PMID: 18256803 Ref: Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer. PMID: 18281498 Ref: Comparison of protein expression by isotope-coded affinity tag labeling. PMID: 18287774 Ref: Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. 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PMID: 18648741 Ref: Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer. PMID: 18661347 Ref: Preoperative radiochemotherapy is successful also in patients with locally advanced rectal cancer who have intrinsically high apoptotic tumours. PMID: 18664561 Ref: NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. PMID: 18692059 Ref: Similar reductions in the risk of human colon cancer by selective and nonselective cyclooxygenase-2 (COX-2) inhibitors. PMID: 18702823 Ref: Cyclooxygenase-2 inhibitors in colorectal cancer prevention: point. PMID: 18708371 Ref: Cyclooxygenase-2 inhibitors in colorectal cancer prevention: counterpoint. PMID: 18708372 Ref: Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence. PMID: 18754318 Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers. PMID: 18794809 Ref: Rosmarinic acid antagonizes activator protein-1-dependent activation of cyclooxygenase-2 expression in human cancer and nonmalignant cell lines. PMID: 18936204 Ref: A 116-kDa phytoglycoprotein inhibits aberrant crypt foci formation through modulation of manganese superoxide dismutase, inducible nitric oxide synthase, cyclooxygenase-2, nuclear factor-kappa B, activator protein-1, and proliferating cell nuclear antigen PMID: 18941370 Ref: Altered gene expression profiles define pathways in colorectal cancer cell lines affected by celecoxib. PMID: 18957522 Ref: Cyclooxygenase-2 expression in pretreatment biopsy as a predictor of tumor responses after preoperative chemoradiation in rectal cancer. PMID: 19015468 Ref: Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis. PMID: 19016757 Ref: Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice. PMID: 19030198 Ref: Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells. PMID: 19042113 Ref: Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab. PMID: 19047118 Ref: Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2-Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice. PMID: 19047153 Ref: The database dbEST correctly predicts gene expression in colon cancer patients. PMID: 19075689 Ref: Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. PMID: 19088039 Ref: EGFR, HER-2 and COX-2 levels in colorectal cancer. PMID: 19102009 Ref: (-)-Epigallocatechin gallate suppresses azoxymethane-induced colonic premalignant lesions in male C57BL/KsJ-db/db mice. PMID: 19138973 Ref: Inhibition of azoxymethane-induced colonic aberrant crypt foci formation by silibinin in male Fisher 344 rats. PMID: 19138982 Ref: Heterogeneous gene expression changes in colorectal cancer cells share the WNT pathway in response to growth suppression by APHS-mediated COX-2 inhibition. PMID: 19707365 Ref: Dose-response assessment of the anti-cancer efficacy of soy isoflavones in dimethylhydrazine-treated rats fed 6% fructooligosaccharide. PMID: 20126366 Ref: Prognostic importance of increased cyclooxygenase-2 levels in colorectal carcinomas: a 5-year single-institution study. PMID: 25610014 |
Ref: COX-2 expression is unexpectedly high in viable colorectal mucosal cells: is there life for chemoprophylaxis after VICTOR? PMID: 18691269 Ref: The simultaneous expression of peroxisome proliferator-activated receptor delta and cyclooxygenase-2 may enhance angiogenesis and tumor venous invasion in tissues of colorectal cancers. PMID: 18720000 Ref: Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. PMID: 18790560 Ref: A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. PMID: 18815359 Ref: Polymorphisms in interleukin 1 beta and interleukin 1 receptor antagonist associated with tumor recurrence in stage II colon cancer. PMID: 18987561 Ref: Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice. PMID: 19003968 Ref: Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer. PMID: 19005184 Ref: Cyclooxygenase-2/carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells. PMID: 19017360 Ref: Aldose reductase deficiency in mice prevents azoxymethane-induced colonic preneoplastic aberrant crypt foci formation. PMID: 19028703 Ref: Association between adenomatosis polyposis coli functional status and microsomal prostaglandin E synthase-1 expression in colorectal cancer. PMID: 19035518 Ref: A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways. PMID: 19037088 Ref: Enhancement of 5-fluorouracil efficacy on high COX-2 expressing HCA-7 cells by low dose indomethacin and NS-398 but not on low COX-2 expressing HT-29 cells. PMID: 19048402 Ref: JC virus T-antigen in colorectal cancer is associated with p53 expression and chromosomal instability, independent of CpG island methylator phenotype. PMID: 19107235 Ref: Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome. PMID: 19121846 Ref: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. PMID: 19133256 Ref: The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. PMID: 19136477 Ref: Colorectal cancer expression of peroxisome proliferator-activated receptor gamma (PPARG, PPARgamma) is associated with good prognosis. PMID: 19186181 Ref: The mRNA binding proteins HuR and tristetraprolin regulate cyclooxygenase 2 expression during colon carcinogenesis. PMID: 19208339 Ref: Prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) 8473T>C polymorphism associated with prognosis for patients with colorectal cancer treated with capecitabine and oxaliplatin. PMID: 19219602 Ref: Rheological, sensorial, and chemopreventive properties of milk fermented with exopolysaccharide-producing lactic cultures. PMID: 19233777 Ref: Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression. PMID: 19244345 Ref: Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells. PMID: 19266600 Ref: Cyclooxygenase-2 and Hypoxia-Inducible Factor-1alpha protein expression is related to inflammation, and up-regulated since the early steps of colorectal carcinogenesis. PMID: 19268443 Ref: Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis. PMID: 19277703 Ref: Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. PMID: 19287974 Ref: AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. PMID: 19293639 Ref: The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. PMID: 19328876 Ref: Cyclooxygenase inhibitors induce colon cancer cell apoptosis Via PPARdelta --> 14-3-3epsilon pathway. PMID: 19347284 Ref: A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2. PMID: 19375854 Ref: Expression of NF-kappaB and COX-2 in young versus older patients with sporadic colorectal cancer. PMID: 19390125 Ref: The cyclooxygenase-2 inhibitor etoricoxib is a potent chemopreventive agent of colon carcinogenesis in the rat model. 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