Primary Site >> Biliary tract Cancer
Gene >> PTGS2
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Ref: Synthetic pathways of gallbladder mucosal prostanoids: the role of cyclooxygenase-1 and 2. PMID: 10328326 |
Ref: Biliary cancer growth factor pathways, cyclo-oxygenase-2 and potential therapeutic strategies. PMID: 11357901 Ref: Significance of contracted cholecystitis lesions as high risk for gallbladder carcinogenesis. PMID: 11410319 Ref: Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. PMID: 11584358 Ref: Constitutive expression of ErbB-2 in gallbladder epithelium results in development of adenocarcinoma. PMID: 11585718 |
Ref: COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. PMID: 11870367 Ref: Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. PMID: 11910351 Ref: Expression of cyclooxygenase-2 in the subserosal layer correlates with postsurgical prognosis of pathological tumor stage 2 carcinoma of the gallbladder. PMID: 11920595 Ref: Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. PMID: 11948128 Ref: Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. PMID: 12143044 Ref: ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. PMID: 12143054 Ref: Cyclooxygenase-2 expression in the adenoma-carcinoma sequence of human gallbladder. PMID: 12190199 |
Ref: Cyclooxygenase-2 expression in the gallbladder of patients with anomalous arrangement of the pancreaticobiliary duct. PMID: 12677571 Ref: Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas. PMID: 12730870 Ref: Celecoxib inhibits proliferation and induces apoptosis via prostaglandin E2 pathway in human cholangiocarcinoma cell lines. PMID: 12800245 Ref: Establishment and characterization of novel xenograft models of human biliary tract carcinomas. PMID: 14532968 Ref: Anatomic and molecular pathology of intrahepatic cholangiocarcinoma. PMID: 14598145 |
Ref: Cyclooxygenase-2 promotes human cholangiocarcinoma growth: evidence for cyclooxygenase-2-independent mechanism in celecoxib-mediated induction of p21waf1/cip1 and p27kip1 and cell cycle arrest. PMID: 14973068 Ref: Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis. PMID: 14999691 Ref: Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. PMID: 15057907 Ref: Expression of cyclooxygenase-2 in cholangiocarcinoma: correlation with clinicopathological features and prognosis. PMID: 15086604 Ref: Different expression of cyclooxygenase-2 in biliary epithelia of bile duct cancer with or without pancreaticobiliary maljunction. PMID: 15161010 Ref: Effects of cyclooxygenase-2 antisense vector on proliferation of human cholangiocarcinoma cells. PMID: 15250241 |
Ref: Cholangiocarcinoma: molecular targeting strategies for chemoprevention and therapy. PMID: 15690474 Ref: Oncolytic adenoviral therapy in gallbladder carcinoma. PMID: 15855925 Ref: Opisthorchis viverrini antigen induces the expression of Toll-like receptor 2 in macrophage RAW cell line. PMID: 15862573 Ref: Cyclooxygenase-2 overexpression is associated with a poor outcome in resected ampullary cancer patients. PMID: 15897577 Ref: Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. PMID: 15921858 Ref: Cyclooxygenase-2 promotes angiogenesis by increasing vascular endothelial growth factor and predicts prognosis in gallbladder carcinoma. PMID: 15968728 Ref: erbB-2/neu transformed rat cholangiocytes recapitulate key cellular and molecular features of human bile duct cancer. PMID: 16344070 Ref: Co-expression of cox-2, C-met and beta-catenin in cells forming invasive front of gallbladder cancer. PMID: 19956499 |
Ref: Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma. PMID: 16168519 Ref: Prostaglandin-endoperoxide synthase 2 (PTGS2) gene polymorphisms and risk of biliary tract cancer and gallstones: a population-based study in Shanghai, China. PMID: 16361272 Ref: COX-2 expression in ampullary carcinoma: correlation with angiogenesis process and clinicopathological variables. PMID: 16489179 Ref: Expression of cyclooxygenase-2 is associated with p53 accumulation in premalignant and malignant gallbladder lesions. PMID: 16733863 Ref: Resampling-based multiple hypothesis testing procedures for genetic case-control association studies. PMID: 16755536 Ref: Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. PMID: 16818635 Ref: Cholangiocarcinoma: modern advances in understanding a deadly old disease. PMID: 17030071 Ref: Cyclooxygenase-2 expression determines neo-angiogenesis in gallbladder carcinomas. PMID: 17177652 |
Ref: Elevated expression of cyclooxygenase-2 is a negative prognostic factor for overall survival in intrahepatic cholangiocarcinoma. PMID: 17165088 Ref: Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice. PMID: 17575102 |
Ref: A novel "patient-like" model of cholangiocarcinoma progression based on bile duct inoculation of tumorigenic rat cholangiocyte cell lines. PMID: 18081149 Ref: Cyclooxygenase-2-derived prostaglandin E2 activates beta-catenin in human cholangiocarcinoma cells: evidence for inhibition of these signaling pathways by omega 3 polyunsaturated fatty acids. PMID: 18199552 Ref: MUC4 interacts with ErbB2 in human gallbladder carcinoma: potential pathobiological implications. PMID: 18397823 Ref: Prognostic value of eicosanoid pathways in extrahepatic cholangiocarcinoma. PMID: 18507031 Ref: Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma. PMID: 19084911 Ref: [Evaluation of immunohistochemical markers for differential diagnosis of hepatocellular carcinoma from intrahepatic cholangiocarcinoma]. PMID: 19173916 |
Ref: Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha. PMID: 19218340 Ref: Functional polymorphisms of the cyclooxygenase (PTGS2) gene and risk for gallbladder cancer in a North Indian population. PMID: 19455278 Ref: Sulindac prevents carcinogen-induced intrahepatic cholangiocarcinoma formation in vivo. PMID: 19564027 Ref: Expression of cyclooxygenase-2, glucose transporter-1 and angiogenesis in gallbladder carcinomas and their impact on prognosis. PMID: 19606394 Ref: Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. PMID: 19621664 Ref: Metachronous Carcinomas of the Biliary Tract in a Patient Treated Three Times with Curative Surgery. PMID: 20651971 |
Ref: Accumulation of neoplastic traits prior to spontaneous in vitro transformation of rat cholangiocytes determines susceptibility to activated ErbB-2/Neu. PMID: 20655306 Ref: Cyclooxygenase-2, p53 and glucose transporter-1 as predictors of malignancy in the development of gallbladder carcinomas. PMID: 20846124 Ref: Strong cytoplasmic expression of COX2 at the invasive fronts of gallbladder cancer is associated with a poor prognosis. PMID: 20924037 |
Ref: Protease-activated receptor-2 regulates cyclooxygenase-2 expression in human bile duct cancer via the pathways of mitogen-activated protein kinases and nuclear factor kappa B. PMID: 20740367 Ref: Carcinogenic effects of "whole-life" exposure to inorganic arsenic in CD1 mice. PMID: 20937726 Ref: Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes. PMID: 21283657 |
Ref: Anti-inflammatory effect of prednisolone on the growth of human liver fluke in experimental opisthorchiasis. PMID: 22186974 Ref: Molecular biology of gallbladder cancer: potential clinical implications. PMID: 23112962 |
Ref: Immunosuppressive prednisolone enhances early cholangiocarcinoma in Syrian hamsters with liver fluke infection and administration of N-nitrosodimethylamine. PMID: 22851165 Ref: Different roles of inducible nitric oxide synthase and cyclooxygenase-2 in carcinogenesis and metastasis of intrahepatic cholangiocarcinoma. PMID: 23260331 Ref: Elevated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in primary sclerosing cholangitis: iotamplications for cholangiocarcinogenesis. PMID: 23900502 Ref: Reappraisal of the therapeutic role of celecoxib in cholangiocarcinoma. PMID: 23922859 |
Ref: Aspirin may prevent cholangiocarcinoma: a case-control study from the United kingdom. PMID: 24535250 Ref: miR-21 targets 15-PGDH and promotes cholangiocarcinoma growth. PMID: 24699315 Ref: COX-2 overexpression in resected pancreatic head adenocarcinomas correlates with favourable prognosis. PMID: 24950702 Ref: Interaction of Muc4 and ErbB2 in a transgenic mouse model of gallbladder carcinoma: potential pathobiological implications. PMID: 25174601 Ref: Expression of epidermal growth factor receptor, p53, Bcl2, vascular endothelial growth factor, cyclooxygenase-2, cyclin D1, human epidermal receptor-2 and Ki-67: Association with clinicopathological profiles and outcomes in gallbladder carcinoma. PMID: 25225463 Ref: Gallbladder cancer: Clinical and pathological approach. PMID: 25325061 |
Ref: Association between variants in inflammation and cancer-associated genes and risk and survival of cholangiocarcinoma. PMID: 26276523 Ref: Expression and Significance of COX-2 and Ki-67 in Hepatolithiasis with Bile Duct Carcinoma. PMID: 26423666 Ref: Influence of Photodynamic Therapy on Apoptosis and Invasion of Human Cholangiocarcinoma QBC939 Cell Line. PMID: 26960307 |
Ref: Epigenetic profiling of gallbladder cancer and gall stone diseases: Evaluation of role of tumour associated genes. PMID: 26456195 Ref: Integrin beta3 and LKB1 are independently involved in the inhibition of proliferation by lovastatin in human intrahepatic cholangiocarcinoma. PMID: 26517522 Ref: EGFR, COX2, p-AKT expression and PIK3CA mutation in distal extrahepatic bile duct carcinoma. PMID: 27020207 |
Ref: Combination of celecoxib and PD184161 exerts synergistic inhibitory effects on gallbladder cancer cell proliferation. PMID: 28521485 |
Ref: Intrahepatic cholangiocarcinoma after Fontan procedure in an adult with visceral heterotaxy. PMID: 29559246 Ref: PF-2341066 combined with celecoxib promotes apoptosis and inhibits proliferation in human cholangiocarcinoma QBC939 cells. PMID: 29725387 |