Primary Site >> Colorectal Cancer

Gene >> PRODH

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Ref: Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species.
PMID: 11280728
Ref: Technology evaluation: CEA-TRICOM, Therion Biologics Corp.
PMID: 11525565
 Ref: Technology evaluation: ALVAC-CEA/B7.1, Aventis Pasteur/Therion.
PMID: 12596363
 Ref: MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells.
PMID: 15817612
 Ref: Proline oxidase, a proapoptotic gene, is induced by troglitazone: evidence for both peroxisome proliferator-activated receptor gamma-dependent and -independent mechanisms.
PMID: 16303758
Ref: Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling.
PMID: 16619034
Ref: Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: initial identification of predictive biomarkers.
PMID: 16619291
 Ref: Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis.
PMID: 16874462
 Ref: Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.
PMID: 18794809
 Ref: Regulation and function of proline oxidase under nutrient stress.
PMID: 19415679
 Ref: Polymorphisms in inflammatory pathway genes and their association with colorectal cancer risk.
PMID: 21351261