Primary Site >> Colorectal Cancer
Gene >> PRKN
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Ref: Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. PMID: 16287063 Ref: Rac1, but not Rac1B, stimulates RelB-mediated gene transcription in colorectal cancer cells. PMID: 16551621 |
Ref: Synphilin-1A inhibits seven in absentia homolog (SIAH) and modulates alpha-synuclein monoubiquitylation and inclusion formation. PMID: 19224863 Ref: Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers. PMID: 19585504 |
Ref: PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. PMID: 20696900 |
Ref: Enhancement of TGF-beta signaling responses by the E3 ubiquitin ligase Arkadia provides tumor suppression in colorectal cancer. PMID: 21998011 |
Ref: The tumor suppressor CDC73 interacts with the ring finger proteins RNF20 and RNF40 and is required for the maintenance of histone 2B monoubiquitination. PMID: 22021426 |
Ref: Somatic mutation of PARK2 tumor suppressor gene is not common in common solid cancers. PMID: 23225159 |
Ref: Association of PARK2 promoter polymorphisms and methylation with colorectal cancer in North Indian population. PMID: 30296568 |