Primary Site >> Colorectal Cancer
Gene >> PRKCA
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Ref: Dual role for protein kinase C alpha as a regulator of ion secretion in the HT29cl.19A human colonic cell line. PMID: 1637359 |
Ref: Decreased levels of protein kinase C enzyme activity and protein kinase C mRNA in primary colon tumors. PMID: 8404381 |
Ref: Expression of multiple isoforms of protein kinase C in normal human colon mucosa and colon tumors and decreased levels of protein kinase C beta and eta mRNAs in the tumors. PMID: 7999261 Ref: Evidence that protein kinase C-alpha activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells. PMID: 8053934 |
Ref: Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. PMID: 7705931 Ref: Role of protein kinase C alpha in the induction of carcinoembryonic antigen by transforming growth factor beta 1. PMID: 7790386 Ref: Dietary fat and fiber alter rat colonic protein kinase C isozyme expression. PMID: 7815176 Ref: Differential expression of protein kinase C isoforms in human colorectal cancers. PMID: 7861778 Ref: Noninvasive detection of putative biomarkers for colon cancer using fecal messenger RNA. PMID: 8547831 |
Ref: Increased expression of protein kinase C beta activates ERK3. PMID: 8626698 Ref: Inhibition of growth of human tumor cell lines in nude mice by an antisense of oligonucleotide inhibitor of protein kinase C-alpha expression. PMID: 8758918 Ref: Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression. PMID: 9414406 |
Ref: Protein kinase C-epsilon is the likely mediator of mucin exocytosis in human colonic cell lines. PMID: 9038873 Ref: Dietary fish oil blocks carcinogen-induced down-regulation of colonic protein kinase C isozymes. PMID: 9054628 Ref: TPA induces transglutaminase C and inhibits cell growth in the colon carcinoma cell line SW620. PMID: 9126346 Ref: Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-alpha (PKC-alpha) pseudosubstrate peptides through a P-glycoprotein-independent mechanism. PMID: 9547673 Ref: Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. PMID: 21533493 |
Ref: Decreased PKC-alpha expression increases cellular proliferation, decreases differentiation, and enhances the transformed phenotype of CaCo-2 cells. PMID: 9500474 Ref: Down-regulation of protein kinase C-alpha detected in human colorectal cancer. PMID: 9556213 Ref: Protein kinase Calpha controls the adhesion but not the antiproliferative response of human colon carcinoma cells to transforming growth factor beta1: identification of two distinct branches of post-protein kinase Calpha adhesion signal pathway. PMID: 9564886 Ref: Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes. PMID: 9649461 |
Ref: Increased transforming growth factor-alpha levels in human colon carcinoma cell lines over-expressing protein kinase C. PMID: 9935234 Ref: 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent Caco-2 cell differentiation. PMID: 10585423 |
Ref: Induction of cancer cell apoptosis by alpha-tocopheryl succinate: molecular pathways and structural requirements. PMID: 11156956 Ref: Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. PMID: 11245437 Ref: Dietary copper and dimethylhydrazine affect protein kinase C isozyme protein and mRNA expression and the formation of aberrant crypts in colon of rats. PMID: 11673641 |
Ref: Dietary copper affects azoxymethane-induced intestinal tumor formation and protein kinase C isozyme protein and mRNA expression in colon of rats. PMID: 11983831 |
Ref: Adherens junctions and tight junctions are regulated via different pathways by progastrin in epithelial cells. PMID: 12615962 |
Ref: Regulation of phorbol ester-mediated TRAF1 induction in human colon cancer cells through a PKC/RAF/ERK/NF-kappaB-dependent pathway. PMID: 14981539 Ref: [Cell membrane phospholipid variation and protein kinase C expression effects on hepatic metastasis of large intestinal carcinoma]. PMID: 15009987 Ref: Extracellular pressure stimulates colon cancer cell proliferation via a mechanism requiring PKC and tyrosine kinase signals. PMID: 15548175 |
Ref: Myricetin inhibits matrix metalloproteinase 2 protein expression and enzyme activity in colorectal carcinoma cells. PMID: 15713899 Ref: Bile acid induces hydrophobicity-dependent membrane alterations. PMID: 15951237 Ref: Ursodeoxycholic acid inhibits translocation of protein kinase C in human colonic cancer cell lines. PMID: 16122920 |
Ref: Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. PMID: 16554470 Ref: Protein kinase C alpha but not PKCzeta suppresses intestinal tumor formation in ApcMin/+ mice. PMID: 16849539 Ref: Alpha2beta1 integrin signalling enhances cyclooxygenase-2 expression in intestinal epithelial cells. PMID: 16972245 Ref: Neurotensin phosphorylates GSK-3alpha/beta through the activation of PKC in human colon cancer cells. PMID: 16984735 |
Ref: Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. PMID: 17542601 |
Ref: The phosphatase PHLPP controls the cellular levels of protein kinase C. PMID: 18162466 Ref: Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells. PMID: 18413805 Ref: Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. PMID: 18694510 Ref: Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells. PMID: 19034280 |
Ref: PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1. PMID: 19232344 Ref: Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. PMID: 19417139 Ref: Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin. PMID: 20141613 |
Ref: Polar 3-alkylidene-5-pivaloyloxymethyl-5'-hydroxymethyl-gamma-lactones as protein kinase C ligands and antitumor agents. PMID: 20045644 Ref: RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. PMID: 20122401 |
Ref: Protein kinase Calpha signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium. PMID: 21454537 Ref: Berberine Reduces cAMP-Induced Chloride Secretion in T84 Human Colonic Carcinoma Cells through Inhibition of Basolateral KCNQ1 Channels. PMID: 21747769 |
Ref: Protein kinase Calpha protects against multidrug resistance in human colon cancer cells. PMID: 22639047 Ref: The NF-kappaB target genes ICAM-1 and VCAM-1 are differentially regulated during spontaneous differentiation of Caco-2 cells. PMID: 22742445 Ref: C1B domain peptide of protein kinase Cgamma significantly suppresses growth of human colon cancer cells in vitro and in an in vivo mouse xenograft model through induction of cell cycle arrest and apoptosis. PMID: 22785210 Ref: Targeting of Noncanonical Wnt5a Signaling by AP-1 Blocker Dominant-Negative Jun When It Inhibits Skin Carcinogenesis. PMID: 22893789 Ref: A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation. PMID: 23059825 Ref: Resveratrol affects protein kinase C activity and promotes apoptosis in human colon carcinoma cells. PMID: 23464396 |
Ref: Nuclear factor-E2 (Nrf2) is regulated through the differential activation of ERK1/2 and PKC alpha/betaII by Gymnasterkoreayne B. PMID: 23219897 Ref: Involvement of PKCalpha activation in TF/VIIa/PAR2-induced proliferation, migration, and survival of colon cancer cell SW620. PMID: 23233043 Ref: TF/FVIIa/PAR2 promotes cell proliferation and migration via PKCalpha and ERK-dependent c-Jun/AP-1 pathway in colon cancer cell line SW620. PMID: 23616010 Ref: Brucine suppresses colon cancer cells growth via mediating KDR signalling pathway. PMID: 23905676 |
Ref: Netrin-1 induces MMP-12-dependent E-cadherin degradation via the distinct activation of PKCalpha and FAK/Fyn in promoting mesenchymal stem cell motility. PMID: 24738865 Ref: The hidden switches underlying RORalpha-mediated circuits that critically regulate uncontrolled cell proliferation. PMID: 24831657 Ref: Differential regulation of cyclin D1 expression by protein kinase C alpha and signaling in intestinal epithelial cells. PMID: 24914206 |
Ref: Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2. PMID: 26703243 Ref: Low expression of PKCalpha and high expression of KRAS predict poor prognosis in patients with colorectal cancer. PMID: 27602102 |
Ref: N-myc downstream-regulated gene 1 promotes oxaliplatin-triggered apoptosis in colorectal cancer cells via enhancing the ubiquitination of Bcl-2. PMID: 28537875 Ref: Stabilization of Sur8 via PKCalpha/delta degradation promotes transformation and migration of colorectal cancer cells. PMID: 29383184 |
Ref: PKCalpha in colon cancer cells promotes M1 macrophage polarization via MKK3/6-P38 MAPK pathway. PMID: 29637628 Ref: Efficacy of the MEK Inhibitor Cobimetinib and its Potential Application to Colorectal Cancer Cells. PMID: 29794421 Ref: AKR1B10 activates diacylglycerol (DAG) second messenger in breast cancer cells. PMID: 29846015 Ref: Copy number variation analysis and targeted NGS in 77 families with suspected Lynch syndrome reveals novel potential causative genes. PMID: 29987844 |