Primary Site >> Colorectal Cancer

Gene >> POLE3

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Ref: Active human immunodeficiency virus protease is required for viral infectivity.
PMID: 3290901
Ref: [A case of solitary splenic metastasis from colon cancer].
PMID: 9032789
Ref: Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside.
PMID: 15454695
Ref: Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of Smac/DIABLO from the mitochondria.
PMID: 16998592
Ref: Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells.
PMID: 17597109
Ref: A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma.
PMID: 18560353
Ref: Antibody-mediated FOXP3 protein therapy induces apoptosis in cancer cells in vitro and inhibits metastasis in vivo.
PMID: 19513564
Ref: PEG-liposomal oxaliplatin potentialization of antitumor efficiency in a nude mouse tumor-xenograft model of colorectal carcinoma.
PMID: 21455585
Ref: PEG-liposomal oxaliplatin induces apoptosis in human colorectal cancer cells via Fas/FasL and caspase-8.
PMID: 21888623
Ref: Epithelial to mesenchymal transition and cancer stem cell phenotypes leading to liver metastasis are abrogated by the novel TGFbeta1-targeting peptides P17 and P144.
PMID: 23153552
Ref: PEG-liposomal oxaliplatin combined with nuclear factor-kappaB inhibitor (PDTC) induces apoptosis in human colorectal cancer cells.
PMID: 25174808
Ref: Frequency and phenotypic spectrum of germline mutations in POLE and seven other polymerase genes in 266 patients with colorectal adenomas and carcinomas.
PMID: 25529843
Ref: Co-migration of colon cancer cells and CAFs induced by TGFbeta(1) enhances liver metastasis.
PMID: 25557989
Ref: Therapeutic strategies against cancer stem cells in human colorectal cancer.
PMID: 29250169