Primary Site >> Colorectal Cancer
Gene >> PMS1
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Ref: Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. PMID: 8371783 |
Ref: Mutagenesis of yeast MW104-1B strain has identified the uncharacterized PMS6 DNA mismatch repair gene locus and additional alleles of existing PMS1, PMS2 and MSH2 genes. PMID: 7521009 |
Ref: Contribution of molecular oncology in the detection of colorectal carcinomas. PMID: 7491839 Ref: Clinical implications of advances in the molecular genetics of colorectal cancer. PMID: 7571049 Ref: Update on the differential diagnosis, surveillance and management of hereditary non-polyposis colorectal cancer. PMID: 7576988 Ref: Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas. PMID: 7585634 Ref: Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome. PMID: 7616541 Ref: Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. PMID: 7674315 Ref: Genomic structure of human mismatch repair gene, hMLH1, and its mutation analysis in patients with hereditary non-polyposis colorectal cancer (HNPCC) PMID: 7757073 Ref: Mutation screening in the hMLH1 gene in Swedish hereditary nonpolyposis colon cancer families. PMID: 8521398 |
Ref: Overview of natural history, pathology, molecular genetics and management of HNPCC (Lynch Syndrome). PMID: 8600057 Ref: Genetic heterogeneity and unmapped genes for colorectal cancer. PMID: 8640829 Ref: Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype. PMID: 8649458 Ref: Frequent microsatellite instabilities and analyses of the related genes in familial gastric cancers. PMID: 8766523 Ref: Recent developments in hereditary nonpolyposis colorectal cancer. PMID: 8865457 Ref: Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. PMID: 8872463 Ref: Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome. PMID: 8880570 Ref: Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes. PMID: 8895729 Ref: Mismatch repair and cancer. PMID: 8977028 Ref: [Microsatellite instability--a new aspects in genetics and molecular biology of hereditary nonpolyposis and sporadic colorectal tumors]. PMID: 9082661 Ref: DNA mismatch repair deficient mice in cancer research. PMID: 9110401 |
Ref: Microsatellite instability in human solid tumors. PMID: 9060003 Ref: An update of HNPCC (Lynch syndrome). PMID: 9062584 Ref: DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. PMID: 9088350 Ref: Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees. PMID: 9288790 Ref: Hereditary nonpolyposis colorectal cancer families not complying with the Amsterdam criteria show extremely low frequency of mismatch-repair-gene mutations. PMID: 9311737 Ref: Germline hMSH2 and hMLH1 gene mutations in incomplete HNPCC families. PMID: 9399661 Ref: Etiology, natural history, management and molecular genetics of hereditary nonpolyposis colorectal cancer (Lynch syndromes): genetic counseling implications. PMID: 9419392 Ref: Molecular biology of colorectal cancer. PMID: 9438104 Ref: Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. PMID: 9491849 Ref: Cancer genetics in the new era of molecular biology. PMID: 9616736 Ref: Decreased expression of MLH1, MSH2, PMS1 and PMS2 in pigmented lesions indicates accumulation of failed DNA repair along with malignant transformation and tumour progression. PMID: 21590118 |
Ref: Molecular genetics and clinical-pathology features of hereditary nonpolyposis colorectal carcinoma (Lynch syndrome): historical journey from pedigree anecdote to molecular genetic confirmation. PMID: 9499183 Ref: Genetic identification and management of hereditary nonpolyposis colorectal cancer. PMID: 9499460 Ref: Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. PMID: 9500552 Ref: Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. PMID: 9592192 Ref: DGGE screening of mutations in mismatch repair genes (hMSH2 and hMLH1) in 34 Swedish families with colorectal cancer. PMID: 9611074 Ref: Functional genetic tests of DNA mismatch repair protein activity in Saccharomyces cerevisiae. PMID: 9630599 Ref: Genetics of colonic cancer. PMID: 9705533 Ref: Clinical findings with implications for genetic testing in families with clustering of colorectal cancer. PMID: 9709044 Ref: Expression of the mismatch repair gene hMSH2 in sporadic colorectal cancer. PMID: 9824623 Ref: Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer. PMID: 9855004 Ref: hMLH1 mutations in hereditary nonpolyposis colorectal cancer kindreds. Mutations in brief no. 182. Online. PMID: 10660333 |
Ref: [Familial cancer: recent advances]. PMID: 10410140 Ref: Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer. PMID: 10448273 Ref: Replication error in colorectal carcinoma: association with loss of heterozygosity at mismatch repair loci and clinicopathological variables. PMID: 10470121 Ref: Prevalence of germline mutations of hMLH1, hMSH2, hPMS1, hPMS2, and hMSH6 genes in 75 French kindreds with nonpolyposis colorectal cancer. PMID: 10480359 Ref: Various mutation screening techniques in the DNA mismatch repair genes hMSH2 and hMLH1. PMID: 10495924 Ref: Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination. PMID: 10523644 Ref: Identification of hMutLbeta, a heterodimer of hMLH1 and hPMS1. PMID: 10542278 Ref: Genetic susceptibility to non-polyposis colorectal cancer. PMID: 10544223 Ref: Strategies for screening for hereditary non-polyposis colorectal cancer. PMID: 10544224 Ref: Clinical and molecular diagnosis of hereditary non-polyposis colorectal cancer: problems and pitfalls in an extended pedigree. PMID: 10575566 Ref: Genetic testing and counseling for hereditary forms of colorectal cancer. PMID: 10630180 Ref: Germline mutation and genome instability. PMID: 10772416 |
Ref: MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. PMID: 10615123 Ref: Identification of a second MutL DNA mismatch repair complex (hPMS1 and hMLH1) in human epithelial cells. PMID: 10748105 Ref: Identification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNA. PMID: 10748159 Ref: [Diagnosis by directed mutagenesis of a mutation at the hMSH2 gene associated with hereditary nonpolyposis colorectal cancer]. PMID: 10962807 Ref: Surveillance on mutation carriers of DNA mismatch repair genes. PMID: 11079789 |
Ref: Age-associated risk of cancer among individuals with N-acetyltransferase 2 (NAT2) mutations and mutations in DNA mismatch repair genes. PMID: 11245417 Ref: Germline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers. PMID: 11317354 Ref: [From gene to disease; from DNA 'mismatch' repair genes to hereditary non-polyposis colorectal carcinoma]. PMID: 11346916 Ref: The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. PMID: 11691795 Ref: Chemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation? PMID: 14574006 Ref: Immunostaining human paraffin-embedded sections for mismatch repair proteins. PMID: 21340794 |
Ref: Mismatch repair and the hereditary non-polyposis colorectal cancer syndrome (HNPCC). PMID: 11852992 Ref: Prevalence of germline mutations of MLH1 and MSH2 in hereditary nonpolyposis colorectal cancer families from Spain. PMID: 11920650 Ref: A hMLH1 genomic mutation and associated novel mRNA defects in a hereditary non-polyposis colorectal cancer family. PMID: 12052501 Ref: Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins. PMID: 12107548 Ref: Analysis of mismatch repair defects in the familial occurrence of lymphoma and colorectal cancer. PMID: 12400605 |
Ref: Molecular dimensions of gastrointestinal tumors: some thoughts for digestion. PMID: 14518068 |
Ref: Hereditary non-polyposis colorectal cancer and the role of hPMS2 and hEXO1 mutations. PMID: 14756672 Ref: Clinical features and mismatch repair gene mutation screening in Chinese patients with hereditary nonpolyposis colorectal carcinoma. PMID: 15309712 Ref: Characterization of mutator phenotype in familial colorectal cancer patients not fulfilling amsterdam criteria. PMID: 15448003 Ref: High-throughput gene sequencing assay development for hereditary nonpolyposis colon cancer. PMID: 15555211 |
Ref: Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. PMID: 16204034 |
Ref: Common variants in mismatch repair genes and risk of colorectal cancer. PMID: 18364438 Ref: Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression. PMID: 18551179 |
Ref: Common germline variation in mismatch repair genes and survival after a diagnosis of colorectal cancer. PMID: 19115210 Ref: Mismatch repair genes in Lynch syndrome: a review. PMID: 19466295 Ref: Impact of 226C>T MSH2 gene mutation on cancer phenotypes in two HNPCC-associated highly-consanguineous families from Kuwait: emphasis on premarital genetic testing. PMID: 19669601 |
Ref: Three novel germline mutations in MLH1 and MSH2 in families with Lynch syndrome living on Jeju island, Korea. PMID: 21034533 |
Ref: Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. PMID: 22321913 |
Ref: Evaluation of tumor suppressor gene expressions and aberrant methylation in the colon of cancer-induced rats: a pilot study. PMID: 24065530 Ref: Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway. PMID: 24204293 |
Ref: Mismatch repair deficiency in ovarian cancer -- molecular characteristics and clinical implications. PMID: 24333356 Ref: Relationship of mismatch repair proteins and survivin in colon polyps and carcinomas. PMID: 24852932 Ref: Synchronous gastric and sebaceous cancers, a rare manifestation of MLH1-related Muir-Torre syndrome. PMID: 25197397 |
Ref: Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers. PMID: 25777966 Ref: Segregation of a novel MLH1 mutation in an Iranian Lynch syndrome family. PMID: 26149658 Ref: Clinical and Molecular Characterization of Brazilian Patients Suspected to Have Lynch Syndrome. PMID: 26437257 |
Ref: [Founder mutation in Lynch syndrome]. PMID: 27295708 Ref: Prediction of biological behavior and prognosis of colorectal cancer patients by tumor MSI/MMR in the Chinese population. PMID: 27994472 |
Ref: Mismatch Repair Deficiency, Microsatellite Instability, and Survival: An Exploratory Analysis of the Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) Trial. PMID: 28241187 Ref: Schizosaccharomyces pombe MutSalpha and MutLalpha Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats. PMID: 28341698 Ref: DNA mismatch repair deficiency and hereditary syndromes in Latino patients with colorectal cancer. PMID: 28640387 Ref: Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer. PMID: 28672935 Ref: DNA mismatch repair deficiency in lung and oral cavity carcinomas: the role of histogenetic origin. PMID: 28730763 Ref: The prognostic role of microsatellite instability in colorectal cancer patients. PMID: 28874631 |
Ref: Novel MSH2 splice-site mutation in a young patient with Lynch syndrome. PMID: 29568967 Ref: Mismatch repair-deficient status associates with favorable prognosis of Eastern Chinese population with sporadic colorectal cancer. PMID: 29725427 Ref: Mismatch repair protein expression in patients with stage II and III sporadic colorectal cancer. PMID: 29849807 Ref: Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma. PMID: 30056163 |