Primary Site >> Esophagus Cancer

Gene >> PLK1

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Ref: Prognostic significance of polo-like kinase expression in esophageal carcinoma.
PMID: 10493949
 Ref: Downregulation of human polo-like kinase activity by antisense oligonucleotides induces growth inhibition in cancer cells.
PMID: 12082631
 Ref: Polo-like kinases (Plks) and cancer.
PMID: 15640844
 Ref: Polo-like kinase and survivin are esophageal tumor-specific promoters.
PMID: 16487489
 Ref: Cytogenetic characterization and gene expression profiling in the rat reflux-induced esophageal tumor model.
PMID: 17320581
 Ref: Silencing of polo-like kinase (Plk) 1 via siRNA causes inhibition of growth and induction of apoptosis in human esophageal cancer cells.
PMID: 18714168
 Ref: Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer.
PMID: 21170987
Ref: Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies.
PMID: 21459796
Ref: PLK1 Is transcriptionally activated by NF-kappaB during cell detachment and enhances anoikis resistance through inhibiting beta-catenin degradation in esophageal squamous cell carcinoma.
PMID: 21610149
 Ref: Reciprocal activation between PLK1 and Stat3 contributes to survival and proliferation of esophageal cancer cells.
PMID: 22108192
 Ref: Moscatilin induces apoptosis and mitotic catastrophe in human esophageal cancer cells.
PMID: 24074296
 Ref: Plk1-targeted therapies in TP53- or RAS-mutated cancer.
PMID: 24630986
Ref: miR210 regulates esophageal cancer cell proliferation by inducing G2/M phase cell cycle arrest through targeting PLK1.
PMID: 25069478
 Ref: Association of ECRG4 with PLK1, CDK4, PLOD1 and PLOD2 in esophageal squamous cell carcinoma.
PMID: 28861165
 Ref: Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling.
PMID: 29339720
Ref: The vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde induces aberrant mitotic progression and enhances radio-sensitivity accompanying suppression the expression of PLK1 in esophageal squamous cell carcinoma.
PMID: 29679654