Primary Site >> Colorectal Cancer
Gene >> PLD2
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Ref: Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer. PMID: 12601529 Ref: Increased activity and expression of phospholipase D2 in human colorectal cancer. PMID: 14552589 |
Ref: Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation. PMID: 16824927 |
Ref: Expression of phospholipase D2 in human colorectal carcinoma. PMID: 17914593 |
Ref: Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. PMID: 18084005 |
Ref: Identification of differential proteins in colon cancer SW480 cells with HIF1-alpha silence by proteome analysis. PMID: 20429620 Ref: Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340 |
Ref: The C-terminal domain of PLD2 participates in degradation of protein kinase CKII beta subunit in human colorectal carcinoma cells. PMID: 21944249 |
Ref: Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. PMID: 25064843 Ref: Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. PMID: 25475140 |
Ref: Hypoxia-inducible factor 1-alpha up-regulates the expression of phospholipase D2 in colon cancer cells under hypoxic conditions. PMID: 25432699 |
Ref: Inhibition of phospholipaseD2 increases hypoxia-induced human colon cancer cell apoptosis through inactivating of the PI3K/AKT signaling pathway. PMID: 26614430 Ref: Regulation of protein kinase CK2 catalytic activity by protein kinase C and phospholipase D2. PMID: 26703243 |
Ref: Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment. PMID: 30305726 |