Primary Site >> Colorectal Cancer
Gene >> PLD1
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Ref: Phorbol ester up-regulates phospholipase D1 but not phospholipase D2 expression through a PKC/Ras/ERK/NFkappaB-dependent pathway and enhances matrix metalloproteinase-9 secretion in colon cancer cells. PMID: 18084005 |
Ref: Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor. PMID: 19994725 |
Ref: Positive feedback regulation between phospholipase D and Wnt signaling promotes Wnt-driven anchorage-independent growth of colorectal cancer cells. PMID: 20711340 |
Ref: Phospholipase D2 downregulation induces cellular senescence through a reactive oxygen species-p53-p21Cip1/WAF1 pathway. PMID: 25064843 Ref: Inhibition of phospholipase D2 induces autophagy in colorectal cancer cells. PMID: 25475140 |
Ref: Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling beta-catenin signaling in cancer-initiating cells. PMID: 26122663 |
Ref: Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. PMID: 27793841 Ref: Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/beta-Catenin and PI3K/Akt Signaling. PMID: 28939743 |
Ref: LCMS/MS metabolome analysis detects the changes in the lipid metabolic profiles of dMMR and pMMR cells. PMID: 29989648 Ref: Screening key long non-coding RNAs in early-stage colon adenocarcinoma by RNA-sequencing. PMID: 30182733 |