Primary Site >> Stomach Cancer
Gene >> PLAU
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Ref: Plasminogen activators and plasminogen activator inhibitor in malignant and non-malignant ascitic fluid. PMID: 2852112 Ref: Secretion of plasminogen activators by human colorectal and gastric tumor explants. PMID: 3409559 |
Ref: Plasminogen activators in endoscopic biopsies as indicators of gastrointestinal cancer: comparison with resection specimens. PMID: 2506920 |
Ref: Relationship between plasminogen activators and stomach carcinoma stage. PMID: 1764272 Ref: Plasminogen activators in human gastric cancers: correlation with DNA ploidy and immunohistochemical staining. PMID: 1902201 |
Ref: Fibronectin degradation by human gastric carcinoma cell lines and its associated proteases in relation to stromal invasion in nude mice. PMID: 1298740 Ref: Possible role of plasminogen activator inhibitor 2 in the prevention of the metastasis of gastric cancer tissues. PMID: 1636163 |
Ref: Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach. PMID: 8432457 |
Ref: Tumour-associated proteolytic factors uPA and PAI-1 and survival in totally resected gastric cancer. PMID: 7903748 Ref: [Pathogenesis and progression of scirrhous carcinoma]. PMID: 7944478 Ref: Prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in completely resected gastric cancer. PMID: 8187075 Ref: Prognostic value of urokinase-type plasminogen activators in gastric-cancer. PMID: 21607438 |
Ref: [Correlation between the expression of urokinase-type plasminogen activator, E-cadherin and malignancy in gastric cancer]. PMID: 7611774 Ref: Tumor-associated proteolysis and prognosis: new functional risk factors in gastric cancer defined by the urokinase-type plasminogen activator system. PMID: 7636552 Ref: Cysteine and serine proteases in gastric cancer. PMID: 8625115 Ref: E-cadherin and urokinase-type plasminogen activator tissue status in gastric carcinoma. PMID: 8625219 Ref: The role of urokinase-type plasminogen activator and its inhibitor PAI-1 in gastric cancer. PMID: 8852646 |
Ref: Prognostic relevance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors PAI-1 and PAI-2 in gastric cancer. PMID: 8624578 Ref: Prognostic value of the plasminogen activation system in patients with gastric carcinoma. PMID: 8635120 Ref: Expression of urokinase-type plasminogen activator, its receptor, and its inhibitor in gastric adenocarcinoma tissues. PMID: 8703368 Ref: The prognostic impact of the urokinase-type plasminogen activator system is associated with tumour differentiation in gastric cancer. PMID: 8846873 Ref: Expression of oncoproteins and the amount of eosinophilic and lymphocytic infiltrates can be used as prognostic factors in gastric cancer. Dutch Gastric Cancer Group (DGCG). PMID: 8956793 Ref: Increased levels of cathepsin B and L, urokinase-type plasminogen activator and its inhibitor type-1 as an early event in gastric carcinogenesis. PMID: 9006092 Ref: [Prognostic role of cisteine and serin proteases in gastriC cancer]. PMID: 9019701 Ref: Relationship between expression of plasminogen activator system and metastatic ability in human cancers. PMID: 21544336 Ref: Combined evaluation of urokinase-type plasminogen activator and plasminogen activator inhibitor-2 expression in gastric carcinoma. PMID: 21544388 |
Ref: Immunocytochemical phenotyping of disseminated tumor cells in bone marrow by uPA receptor and CK18: investigation of sensitivity and specificity of an immunogold/alkaline phosphatase double staining protocol. PMID: 9016310 Ref: High level of urokinase-type plasminogen activator is a new prognostic marker in patients with gastric carcinoma. PMID: 9041148 Ref: Urokinase plasminogen activator receptor (uPA-R): one potential characteristic of metastatic phenotypes in minimal residual tumor disease. PMID: 9102229 Ref: Melanoma antigen-encoding gene-1 expression in invasive gastric carcinoma: correlation with stage of disease. PMID: 9121149 Ref: Co-expression of urokinase-type plasminogen activator and its receptor in human gastric-cancer cell lines correlates with their invasiveness and tumorigenicity. PMID: 9180158 Ref: An immunohistochemical assessment of cathepsin D in gastric carcinoma: its impact on clinical prognosis. PMID: 9217027 Ref: Urokinase-type plasminogen activator receptor in gastric cancer: tissue expression and prognostic role. PMID: 9219730 Ref: A new prognostic strategy for gastric carcinoma: mRNA expression of tumor growth-related factors in endoscopic biopsy specimens. PMID: 9242335 Ref: [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]. PMID: 9263524 Ref: Comparison of biological phenotypes according to midkine expression in gastric cancer cells and their autocrine activities could be modulated by pentosan polysulfate. PMID: 9310258 Ref: Clinical value of extended biologic staging by bone marrow micrometastases and tumor-associated proteases in gastric cancer. PMID: 9409572 Ref: Prognostic factors in gastric cancer. PMID: 9448610 |
Ref: Prognostic relevance of MMP-2 (72-kD collagenase IV) in gastric cancer. PMID: 9499190 Ref: Tumor-associated proteases and inhibitors in gastric cancer: analysis of prognostic impact and individual risk protease patterns. PMID: 9502078 Ref: Diagnostic and prognostic values of plasma levels of fibrinolytic markers in gastric cancer. PMID: 9700849 Ref: Augmented membrane type 1 matrix metalloproteinase (MT1-MMP):MMP-2 messenger RNA ratio in gastric carcinomas with poor prognosis. PMID: 9748137 Ref: Expression of urokinase-type plasminogen activator receptor and plasminogen activator inhibitor-1 in gastric cancer. PMID: 9794194 Ref: Expression of HLA-DR and urokinase-type plasminogen activator in stage IV gastric cancer. PMID: 11957046 Ref: Urokinase receptor antagonists: novel agents for the treatment of cancer. PMID: 15991980 |
Ref: Differing expression of MMPs-1 and -9 and urokinase receptor between diffuse- and intestinal-type gastric carcinoma. PMID: 9988236 Ref: Prognostic impact of stromal cell-derived urokinase-type plasminogen activator in gastric carcinoma. PMID: 10091785 Ref: Immunohistochemical analysis of PAI-2 (plasminogen activator inhibitor type 2) and p53 protein in early gastric cancer patients with recurrence: a preliminary report. PMID: 10340041 Ref: Modulation of biological phenotypes for tumor growth and metastasis by target-specific biological inhibitors in gastric cancer. PMID: 10402490 |
Ref: Prognostic significance of DNA ploidy, S-phase fraction, and tissue levels of aspartic, cysteine, and serine proteases in operable gastric carcinoma. PMID: 10656448 Ref: Proteases in gastrointestinal neoplastic diseases. PMID: 10675722 Ref: c-erbB-2 is of independent prognostic relevance in gastric cancer and is associated with the expression of tumor-associated protease systems. PMID: 10829039 Ref: Urokinase type plasminogen activator and its receptor regulate the invasive potential of gastric cancer cell lines. PMID: 11029504 Ref: Protein-bound polysaccharide PSK inhibits tumor invasiveness by down-regulation of TGF-beta1 and MMPs. PMID: 11448066 |
Ref: Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. PMID: 11280779 Ref: Gastric adenocarcinoma: pathomorphology and molecular pathology. PMID: 11315254 Ref: Her-2/neu and urokinase-type plasminogen activator and its inhibitor in breast cancer. PMID: 11489825 Ref: Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue. PMID: 11751513 |
Ref: Overexpression of urokinase-type plasminogen activator in human gastric cancer cell line (AGS) induces tumorigenicity in severe combined immunodeficient mice. PMID: 11856478 Ref: Prometastatic effect of N-acetylglucosaminyltransferase V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. PMID: 11864986 Ref: Clinical significance of plasma tissue factor pathway and urokinase-type plasminogen activator system in cancer patients. PMID: 12133538 Ref: Src/ERK but not phospholipase D is involved in keratinocyte growth factor-stimulated secretion of matrix metalloprotease-9 and urokinase-type plasminogen activator in SNU-16 human stomach cancer cell. PMID: 12458339 Ref: SB203580, a P38 MAPK Inhibitor, Blocks in vitro Invasion by Human Gastric SNU-638 Cells. PMID: 26680899 |
Ref: Urokinase-type plasminogen activator expression correlates with tumor angiogenesis and poor outcome in gastric cancer. PMID: 12708473 Ref: [Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer]. PMID: 12785198 Ref: Molecular mechanisms of carcinogenesis in gastric cancer. PMID: 12790321 Ref: P38 MAPK pathway is involved in the urokinase plasminogen activator expression in human gastric SNU-638 cells. PMID: 12883725 Ref: Tissue factor-dependent coagulation activation and impaired fibrinolysis in situ in gastric cancer. PMID: 12888933 Ref: Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. PMID: 12907645 Ref: Interferon-gamma suppresses transforming growth factor-beta-induced invasion of gastric carcinoma cells through cross-talk of Smad pathway in a three-dimensional culture model. PMID: 14586410 |
Ref: Relationship between urokinase-type plasminogen receptor, interleukin-8 gene expression and clinicopathological features in gastric cancer. PMID: 15218312 |
Ref: [uPA expression of gastric cancer cell lines and its correlation with peritoneal seeding]. PMID: 15771790 Ref: Relationship between matrix metalloproteinase-2 mRNA expression and clinicopathological and urokinase-type plasminogen activator system parameters and prognosis in human gastric cancer. PMID: 15929171 Ref: [Relationship between urokinase-type plasminogen activator expression and peritoneal metastatic potency in different gastric cancer cell lines]. PMID: 16167240 |
Ref: Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. PMID: 16367923 Ref: Urokinase system expression in gastric carcinoma: prognostic impact in an independent patient series and first evidence of predictive value in preoperative biopsy and intestinal metaplasia specimens. PMID: 16435385 Ref: Regulation of hepatocyte growth factor-mediated urokinase plasminogen activator secretion by MEK/ERK activation in human stomach cancer cell lines. PMID: 16520550 Ref: Hepatocyte growth factor/c-met signaling in regulating urokinase plasminogen activator in human stomach cancer: A potential therapeutic target for human stomach cancer. PMID: 16646560 Ref: Correlative studies on uPA mRNA and uPAR mRNA expression with vascular endothelial growth factor, microvessel density, progression and survival time of patients with gastric cancer. PMID: 16810742 Ref: Is the urokinase-type plasminogen activator system a reliable prognostic factor in gastric cancer? PMID: 17013798 |
Ref: p75 neurotrophin receptor inhibits invasion and metastasis of gastric cancer. PMID: 17510309 Ref: Plaunotol induces apoptosis of gastric cancer cells. PMID: 17691055 |
Ref: Positive VEGF immunostaining independently predicts poor prognosis in curatively resected gastric cancer patients: results of a study assessing a panel of angiogenic markers. PMID: 17972143 Ref: Inhibition of tumor growth and metastasis by ATF-Fc, an engineered antibody targeting urokinase receptor. PMID: 18245952 Ref: Increased expression of the urokinase plasminogen activator system by Helicobacter pylori in gastric epithelial cells. PMID: 18599586 Ref: A small interfering RNA targeting osteopontin as gastric cancer therapeutics. PMID: 18694621 Ref: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. PMID: 18701480 Ref: Clinicopathological significance of urokinase-type plasminogen activator genotypes in gastric cancer. PMID: 19102416 Ref: [Expression of cyclooxygenase-2 and urokinase plasminogen activator in gastric carcinoma and the clinical significance thereof]. PMID: 19159555 Ref: Analysis of NM23 protein and components of plasminogen activation system in tumors of patients with stomach cancer with consideration for disease clinical picture and morphology. PMID: 19513384 |
Ref: Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. PMID: 18805546 Ref: Signaling components involved in Bcl-w-induced migration of gastric cancer cells. PMID: 19097687 Ref: Prognostic value of tumor-related molecular expression in gastric carcinoma. PMID: 19294533 Ref: Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells. PMID: 19497102 Ref: Effects of angiopoietin-1 on attachment and metastasis of human gastric cancer cell line BGC-823. PMID: 19916173 Ref: High preoperative serum vascular endothelial growth factor levels predict poor clinical outcome after curative resection of gastric cancer. PMID: 19918848 |
Ref: Gene expression profile towards the prediction of patient survival of gastric cancer. PMID: 20005068 Ref: Activation of 5-lipoxygenase is required for nicotine mediated epithelial-mesenchymal transition and tumor cell growth. PMID: 20061081 Ref: Hypoxia promotes metastasis in human gastric cancer by up-regulating the 67-kDa laminin receptor. PMID: 20491781 Ref: Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer. PMID: 20559690 Ref: Phenethyl isothiocyanate inhibits migration and invasion of human gastric cancer AGS cells through suppressing MAPK and NF-kappaB signal pathways. PMID: 20651362 Ref: Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro. PMID: 20663323 Ref: [Effects of S-adenosylmethionine on gastric cancer cell lines SGC-7901 and BGC-823]. PMID: 20973239 |
Ref: Effects of shRNA targeting maspin on invasion of gastric carcinoma SGC7901 cell line. PMID: 21109985 Ref: Down-regulation of survivin suppresses uro-plasminogen activator through transcription factor JunB. PMID: 21734448 |
Ref: Global gene expression and functional network analysis of gastric cancer identify extended pathway maps and GPRC5A as a potential biomarker. PMID: 22867946 Ref: A novel animal model for in vivo study of liver cancer metastasis. PMID: 22876040 Ref: u-PA inhibitor amiloride suppresses peritoneal metastasis in gastric cancer. PMID: 23234499 |
Ref: Osteopontin splice variants differentially exert clinicopathological features and biological functions in gastric cancer. PMID: 23289017 Ref: TGF-beta1 alters microRNA profile in human gastric cancer cells. PMID: 23372348 Ref: Semaphorin 5A promotes gastric cancer invasion/metastasis via urokinase-type plasminogen activator/phosphoinositide 3-kinase/protein kinase B. PMID: 23661031 Ref: The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration. PMID: 23993393 Ref: Tumor suppressor ING4 overexpression contributes to proliferation and invasion inhibition in gastric carcinoma by suppressing the NF-kappaB signaling pathway. PMID: 24057236 Ref: IGFBP3, a transcriptional target of homeobox D10, is correlated with the prognosis of gastric cancer. PMID: 24386080 |
Ref: IL-1beta-stimulated urokinase plasminogen activator expression through NF-kappaB in gastric cancer after HGF treatment. PMID: 24626561 Ref: Osteopontin promotes the progression of gastric cancer through the NF-kappaB pathway regulated by the MAPK and PI3K. PMID: 24756245 |
Ref: The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis. PMID: 25263443 Ref: Identification of potential targets for diallyl disulfide in human gastric cancer MGC-803 cells using proteomics approaches. PMID: 25812569 Ref: Effect and prognostic significance of the KAI1 gene in human gastric carcinoma. PMID: 26622792 Ref: Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer. PMID: 26807223 Ref: The Clinical Study of Urokinase-Type Plasminogen Activator and Vascular Endothelial Growth Factor in Gastric Cancer. PMID: 27352182 |
Ref: Suppression of IL-8-Src signalling axis by 17beta-estradiol inhibits human mesenchymal stem cells-mediated gastric cancer invasion. PMID: 26945908 Ref: PAI-1 deficiency increases the trophic effects of hypergastrinemia in the gastric corpus mucosa. PMID: 27038741 Ref: Tspan9 inhibits the proliferation, migration and invasion of human gastric cancer SGC7901 cells via the ERK1/2 pathway. PMID: 27177197 Ref: Suppressive effects on cell proliferation and motility in gastric cancer SGC-7901 cells by introducing ulinastatin in vitro. PMID: 27187019 Ref: Effect of urokinase-type plasminogen activator system in gastric cancer with peritoneal metastasis. PMID: 27313768 Ref: Matrine Suppresses Proliferation and Invasion of SGC7901 Cells through Inactivation of PI3K/Akt/uPA Pathway. PMID: 27650610 Ref: Dapper homolog 1 alpha suppresses metastasis ability of gastric cancer through inhibiting planar cell polarity pathway. PMID: 27833078 |
Ref: Integrated expression analysis identifies transcription networks in mouse and human gastric neoplasia. PMID: 28281307 Ref: In vitro activity of probiotic Lactobacillus reuteri against gastric cancer progression by downregulation of urokinase plasminogen activator/urokinase plasminogen activator receptor gene expression. PMID: 28643742 Ref: Overexpression of forkhead box M1 and urokinase-type plasminogen activator in gastric cancer is associated with cancer progression and poor prognosis. PMID: 29344165 |
Ref: Quercetin Has Antimetastatic Effects on Gastric Cancer Cells via the Interruption of uPA/uPAR Function by Modulating NF-kappab, PKC-delta, ERK1/2, and AMPKalpha. PMID: 28627240 Ref: Global gene expression analysis of knockdown Triosephosphate isomerase (TPI) gene in human gastric cancer cell line MGC-803. PMID: 29307852 Ref: Prognostic value of gastric cancer-associated gene signatures: Evidence based on a meta-analysis using integrated bioinformatics methods. PMID: 30133128 |