Primary Site >> Colorectal Cancer
Gene >> PLAU
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Ref: Proenzyme to urokinase-type plasminogen activator in human colon cancer: in vitro inhibition by monocyte minactivin after proteolytic activation. PMID: 2965017 Ref: Plasminogen activators and tumor development in the human colon: activity levels in normal mucosa, adenomatous polyps, and adenocarcinomas. PMID: 3621160 |
Ref: Plasminogen activators and plasminogen activator inhibitor in malignant and non-malignant ascitic fluid. PMID: 2852112 Ref: Urokinase-type plasminogen activator in colorectal carcinomas and adenomatous polyps: quantitative expression of active and proenzyme. PMID: 3139573 Ref: Plasminogen activators in the intestine of patients with inflammatory bowel disease. PMID: 3146142 Ref: Comparative study of plasminogen activator antigens in colonic carcinomas and adenomas. PMID: 3170033 Ref: Plasminogen activator profiles in neoplastic tissues of the human colon. PMID: 3260815 |
Ref: Urokinase-type plasminogen activator biosynthesis is induced by the EJ-Ha-ras oncogene in CL26 mouse colon carcinoma cells. PMID: 2497073 Ref: Indirect activation of blood coagulation in colon cancer. PMID: 2694422 |
Ref: Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation. PMID: 2114945 Ref: Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells. PMID: 2169614 |
Ref: Localization of urokinase-type plasminogen activator in stromal cells in adenocarcinomas of the colon in humans. PMID: 1702928 Ref: Correlation between urokinase-type plasminogen activator production and the metastatic ability of human rectal cancer cells. PMID: 1765431 Ref: Plasminogen activator inhibitor in stomach and colorectal carcinomas. PMID: 1796298 Ref: The plasminogen activation system in human colon cancer: messenger RNA for the inhibitor PAI-1 is located in endothelial cells in the tumor stroma. PMID: 1855221 Ref: Characterization of a family of high-molecular-weight plasminogen activators secreted by a lung tumor cell line. PMID: 1859826 Ref: Immunohistochemical analysis of plasminogen activator expression in human colorectal carcinomas: correlation with CEA distribution and tumor cell kinetics. PMID: 1901119 Ref: Plasminogen activator inhibitor 1 in human carcinoma tissues. PMID: 1904404 |
Ref: Pathways of coagulation/fibrinolysis activation in malignancy. PMID: 1574711 |
Ref: Sodium butyrate differentially modulates plasminogen activator inhibitor type-1, urokinase plasminogen activator, and its receptor in a human colon carcinoma cell. PMID: 8102211 Ref: Correlation between tumor proliferation and tumor tissue level of urokinase-type plasminogen activator. PMID: 8330641 Ref: The role of the urokinase receptor in extracellular matrix degradation by HT29 human colon carcinoma cells. PMID: 8381394 Ref: Plasminogen activators in normal tissue and carcinomas of the human oesophagus and stomach. PMID: 8432457 Ref: Clinical value of determination of urokinase-type plasminogen activator antigen in plasma for detection of colorectal cancer: comparison with circulating tumor-associated antigens CA 19-9 and carcinoembryonic antigen. PMID: 8467497 Ref: Plasminogen activators and plasminogen activator inhibitors in human colorectal carcinoma tissues are not expressed by the tumour cells. PMID: 8518031 |
Ref: Laminin degradation by human colon carcinoma cells: a role for urinary and tissue plasminogen activators. PMID: 7657515 Ref: Metastasis of human colon tumor cells in vivo: correlation with the overexpression of plasminogen activators and 72 kDa gelatinase. PMID: 7803712 Ref: Expression and release of plasminogen activators, their inhibitors and receptor by human tumor cell lines. PMID: 7872665 Ref: Inactive urokinase and increased levels of its inhibitor type 1 in colorectal cancer liver metastasis. PMID: 7926508 Ref: Chromosomal localization of the human urokinase plasminogen activator receptor and plasminogen activator inhibitor type-2 genes: implications in colorectal cancer. PMID: 7948815 Ref: Human Co115 colon carcinoma cells potentiate the degradation of laminin mediated by tissue-type plasminogen activator. PMID: 7962113 Ref: Prognostic relevance of plasminogen activators and their inhibitors in colorectal cancer. PMID: 8033138 Ref: Immunohistochemical detection of the receptor for urokinase plasminogen activator in human colon cancer. PMID: 8181805 |
Ref: The urokinase/urokinase-receptor system and cancer invasion. PMID: 7549068 Ref: Plasmin-catalyzed proteolysis in colorectal neoplasia. PMID: 7553650 Ref: Antigen levels of urokinase plasminogen activator and its receptor at the tumor-host interface of colorectal adenocarcinomas are related to tumor aggressiveness. PMID: 7557947 Ref: Increase of a urokinase receptor-related low-molecular-weight molecule in colorectal adenocarcinomas. PMID: 7586807 Ref: Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. PMID: 7664291 Ref: Butyrate regulates gene expression of the plasminogen activating system in colon cancer cells. PMID: 7665235 Ref: Localization of urokinase-type plasminogen activator, plasminogen activator inhibitor-1, 2 and plasminogen in colon cancer. PMID: 7737909 Ref: Amiloride modulates urokinase gene expression at both transcription and post-transcription levels in human colon cancer cells. PMID: 7750207 Ref: Association of immunohistochemical detection of urokinase-type plasminogen activator with metastasis and prognosis in colorectal cancer. PMID: 7777251 Ref: Regional variations of urokinase-type plasminogen activator in human colorectal cancer: a quantitative study by image analysis. PMID: 7829235 Ref: In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells. PMID: 7841040 Ref: Sodium butyrate inhibits expression of urokinase and its receptor mRNAs at both transcription and post-transcription levels in colon cancer cells. PMID: 7867787 Ref: Expression of urokinase-type plasminogen activator and plasminogen activator inhibitor in colon disease. PMID: 8587011 |
Ref: Fibrinolysis components as prognostic markers in breast cancer and colorectal carcinoma. PMID: 8694536 Ref: Modulation of the plasminogen activation system by inflammatory cytokines in human colon carcinoma cells. PMID: 8826848 |
Ref: High level of urokinase-type plasminogen activator is a new prognostic marker in patients with gastric carcinoma. PMID: 9041148 Ref: Contribution of plasminogen activators and their inhibitors to the survival prognosis of patients with Dukes' stage B and C colorectal cancer. PMID: 9192984 Ref: [Significance in gene expression of matrix metalloproteinase-9, urokinase-type plasminogen activator and tissue inhibitor of metalloproteinase for metastases of gastric and/or colo-rectal cancer]. PMID: 9263524 Ref: Surface-bound plasmin induces selective proteolysis of insulin-like-growth-factor (IGF)-binding protein-4 (IGFBP-4) and promotes autocrine IGF-II bio-availability in human colon-carcinoma cells. PMID: 9311602 Ref: Urokinase-type plasminogen activator in colorectal cancer: relationship with clinicopathological features and patient outcome. PMID: 9815571 Ref: Combined expression of urokinase-type plasminogen activator and proliferating cell nuclear antigen at the deepest invasive portion correlates with colorectal cancer prognosis. PMID: 21533355 |
Ref: Role of urokinase-type plasminogen activator in local immunotherapy. PMID: 9468551 Ref: The expression of urokinase type plasminogen activator is a novel prognostic factor in dukes B and C colorectal cancer. PMID: 9468574 Ref: Inhibition of establishment of primary and micrometastatic tumors by a urokinase plasminogen activator receptor antagonist. PMID: 9502073 Ref: Involvement of vascular endothelial growth factor and urokinase-type plasminogen activator receptor in microvessel invasion in human colorectal cancers. PMID: 9583734 Ref: Correlates of urokinase-type plasminogen activator in colorectal cancer: positive relationship with nm23 and c-erbB-2 protein expression. PMID: 9613457 Ref: Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. PMID: 9615749 Ref: Short chain fatty acids inhibit human (SW1116) colon cancer cell invasion by reducing urokinase plasminogen activator activity and stimulating TIMP-1 and TIMP-2 activities, rather than via MMP modulation. PMID: 9695737 Ref: Differential effect of radiation on endothelial cell function in rectal cancer and normal rectum. PMID: 9926806 Ref: Adenovirus-mediated delivery of a uPA/uPAR antagonist suppresses angiogenesis-dependent tumor growth and dissemination in mice. PMID: 10326034 Ref: Urokinase receptor antagonists: novel agents for the treatment of cancer. PMID: 15991980 |
Ref: DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. PMID: 10340387 Ref: [Assay and detection methods for urokinase-type plasminogen activator and its related-factors]. PMID: 10396332 Ref: Protein markers in colorectal cancer: predictors of liver metastasis. PMID: 10450731 Ref: [The role of cathepsins and the plasminogen activator/inhibitor system in colorectal cancer]. PMID: 10489782 Ref: Proteolysis in human breast and colorectal cancer. PMID: 10496354 Ref: The role of cysteine and serine proteases in colorectal carcinoma. PMID: 10506696 Ref: Demonstration of urokinase expression in cancer cells of colon adenocarcinomas by immunohistochemistry and in situ hybridization. PMID: 10514394 Ref: Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 as a prognostic factor in human colorectal carcinomas. PMID: 10521987 Ref: Larger and more invasive colorectal carcinoma contains larger amounts of plasminogen activator inhibitor type 1 and its relative ratio over urokinase receptor correlates well with tumor size. PMID: 10594855 Ref: Systemic delivery of antiangiogenic adenovirus AdmATF induces liver resistance to metastasis and prolongs survival of mice. PMID: 10609663 Ref: Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress. PMID: 10850887 |
Ref: Proteases in gastrointestinal neoplastic diseases. PMID: 10675722 Ref: Angiostatin generation by human tumor cell lines: involvement of plasminogen activators. PMID: 10842188 Ref: Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro. PMID: 10861271 Ref: Urokinase-type plasminogen activator and its receptor in colorectal cancer: independent prognostic factors of metastasis and cancer-specific survival and potential therapeutic targets. PMID: 11008205 Ref: Significance of coexpression of urokinase-type plasminogen activator, and matrix metalloproteinase 3 (stromelysin) and 9 (gelatinase B) in colorectal carcinoma. PMID: 11027463 Ref: Antimetastatic and antitumor effects of 2,4-diamino-6-(pyridine-4-yl)-1,3,5-triazine (4PyDAT) on the high lung metastatic colon 26 tumor in mice. PMID: 11049089 Ref: Plasminogen activator system, vascular endothelial growth factor, and colorectal cancer progression. PMID: 11193049 Ref: [The inhibitory effect of asODNs on the invasion of colorectal cancer cell line CCL229]. PMID: 12548848 Ref: Emergency admission with colorectal cancer: its relationship to primary health care organization. PMID: 23578078 |
Ref: A three-dimensional and temporo-spatial model to study invasiveness of cancer cells by heregulin and prostaglandin E2. PMID: 11196203 Ref: Prognostic importance of the soluble plasminogen activator receptor, suPAR, in plasma from rectal cancer patients. PMID: 11267858 Ref: Inhibition of colon cancer metastasis by a 3'- end antisense urokinase receptor mRNA in a nude mouse model. PMID: 11291054 Ref: Urokinase receptor and vascular endothelial growth factor are synergistically associated with the liver metastasis of colorectal cancer. PMID: 11376560 Ref: Short-chain fatty acids inhibit invasive human colon cancer by modulating uPA, TIMP-1, TIMP-2, mutant p53, Bcl-2, Bax, p21 and PCNA protein expression in an in vitro cell culture model. PMID: 11694645 Ref: Hemostatic alterations in patients with benign and malignant colorectal disease during major abdominal surgery. PMID: 11738072 Ref: A C/T polymorphism in the urokinase-type plasminogen activator gene in colorectal cancer. PMID: 11876553 Ref: [The Rudolf Virchow Prize 2001. The role of the oncoprotein beta-catenin ni the progression of colorectal cancers]. PMID: 11894405 |
Ref: High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer. PMID: 11774293 Ref: Plasmin/plasminogen system in colorectal cancer. PMID: 11965442 Ref: Significance of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 (PAI-1) expression in human colorectal carcinomas. PMID: 12218297 Ref: Cyclooxygenase-2 expression correlates with uPAR levels and is responsible for poor prognosis of colorectal cancer. PMID: 12405290 Ref: Antigen levels of the urokinase-type plasminogen activator and its gene polymorphisms in colorectal cancer. PMID: 12430175 Ref: [Comparative analysis of metastatic variants from the colorectal tumor cell line HT-29] PMID: 12601885 |
Ref: Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis. PMID: 12490312 Ref: Quantitative expression of protein markers of plasminogen activation system in prognosis of colorectal cancer. PMID: 12619063 Ref: Proteomic profiling of proteins associated with urokinase plasminogen activator receptor in a colon cancer cell line using an antisense approach. PMID: 12627382 Ref: The plasminogen activator and matrix metalloproteinase systems in colorectal cancer: relationship to tumour pathology. PMID: 12706368 Ref: Defective processing of the transforming growth factor-beta1 in azoxymethane-induced mouse colon tumors. PMID: 12720300 Ref: Increased surgical stress promotes tumor metastasis. PMID: 12773983 Ref: Downregulation of urokinase plasminogen activator receptor expression inhibits Erk signalling with concomitant suppression of invasiveness due to loss of uPAR-beta1 integrin complex in colon cancer cells. PMID: 12865932 Ref: Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer. PMID: 14581368 Ref: Correlation between metastatic potential and variants from colorectal tumor cell line HT-29. PMID: 14606113 |
Ref: Beta-catenin up-regulates the expression of the urokinase plasminogen activator in human colorectal tumors. PMID: 14973118 Ref: NF-kappaB, macrophage migration inhibitory factor and cyclooxygenase-inhibitions as likely mechanisms behind the acetaminophen- and NSAID-prevention of the ovarian cancer. PMID: 15254653 Ref: NS-398 inhibits tumor growth and liver metastasis of colon cancer through induction of apoptosis and suppression of the plasminogen activation system in a mouse model. PMID: 15325613 |
Ref: The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15. PMID: 15767558 Ref: Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells. PMID: 15769846 Ref: Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. PMID: 15849510 Ref: Association of interleukin-8 and plasminogen activator system in the progression of colorectal cancer. PMID: 16088182 |
Ref: Molecular detection of circulating cancer cells in the peripheral blood of patients with colorectal cancer by using membrane array with a multiple mRNA marker panel. PMID: 16391796 Ref: Tumor cell dissemination in colon cancer does not predict extrahepatic recurrence in patients undergoing surgery for hepatic metastases. PMID: 16391868 Ref: Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells. PMID: 16631161 Ref: Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. PMID: 16916471 |
Ref: The expression of low density lipoprotein receptor-related protein in colorectal carcinoma. PMID: 17203175 Ref: Inhibition of urokinase plasminogen activator with a novel enzyme inhibitor, WXC-340, ameliorates endotoxin and surgery-accelerated growth of murine metastases. PMID: 17242699 Ref: Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. PMID: 17275810 Ref: Profiling of selenomethionine responsive genes in colon cancer by microarray analysis. PMID: 17374985 Ref: [The role of p38 MAPK in gastrin-induced u-PA expression in human colon cancer cells]. PMID: 17575684 Ref: Polymorphisms in the genes of the urokinase plasminogen activation system in relation to colorectal cancer. PMID: 17804466 Ref: A urokinase-type plasminogen activator deficiency diminishes the frequency of intestinal adenomas in ApcMin/+ mice. PMID: 17893885 |
Ref: Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer. PMID: 18076013 Ref: Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis. PMID: 18176934 Ref: The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients. PMID: 18193223 Ref: Suppression of integrin alphaupsilonbeta6 by RNA interference in colon cancer cells inhibits extracellular matrix degradation through the MAPK pathway. PMID: 18566996 Ref: Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. PMID: 18616803 Ref: Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. PMID: 18701480 Ref: Differential proteome expression associated with urokinase plasminogen activator receptor (uPAR) suppression in malignant epithelial cancer. PMID: 18808175 Ref: The tumorigenic, invasive and metastatic potential of epithelial and round subpopulations of the SW480 human colon cancer cell line. PMID: 21479483 |
Ref: uPA and PAI-1 in rectal cancer--relationship to radiotherapy and clinical outcome. PMID: 18533186 Ref: Plaunotol and geranylgeraniol induce caspase-mediated apoptosis in colon cancer. PMID: 18805546 Ref: Studies of TGF-beta(1-3) in serosal fluid during abdominal surgery and their effect on in vitro human mesothelial cell proliferation. PMID: 19062040 Ref: Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. PMID: 19123477 Ref: Bacterial endotoxin enhances colorectal cancer cell adhesion and invasion through TLR-4 and NF-kappaB-dependent activation of the urokinase plasminogen activator system. PMID: 19436306 Ref: Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. PMID: 19540205 Ref: Differential prognostic impact of uPA and PAI-1 in colon and rectal cancer. PMID: 19776673 Ref: Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells. PMID: 19820721 Ref: PDEF is a negative regulator of colon cancer cell growth and migration. PMID: 19830706 |
Ref: Urokinase-type plasminogen activator is a marker of aggressive phenotype and an independent prognostic factor in mismatch repair-proficient colorectal cancer. PMID: 19740518 Ref: Benzyl isothiocyanate (BITC) inhibits migration and invasion of human colon cancer HT29 cells by inhibiting matrix metalloproteinase-2/-9 and urokinase plasminogen (uPA) through PKC and MAPK signaling pathway. PMID: 20136087 Ref: Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. PMID: 20360625 Ref: Inhibition of metastasis, angiogenesis, and tumor growth by Chinese herbal cocktail Tien-Hsien Liquid. PMID: 20429953 Ref: Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro. PMID: 20663323 Ref: A pharmacological analysis of the cholinergic regulation of urokinase-type plasminogen activator secretion in the human colon cancer cell line, HT-29. PMID: 20727878 Ref: Tumour budding, uPA and PAI-1 are associated with aggressive behaviour in colon cancer. PMID: 20740581 Ref: GATA6 promotes colon cancer cell invasion by regulating urokinase plasminogen activator gene expression. PMID: 21076612 |
Ref: Expression and activation of proteases in co-cultures. PMID: 19836935 Ref: beta-Catenin and NF-kappaB cooperate to regulate the uPA/uPAR system in cancer cells. PMID: 20473943 Ref: The plasminogen activator inhibitor system in colon cancer cell lines is influenced by the CO2 pneumoperitoneum. PMID: 20931209 Ref: p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. PMID: 21353507 Ref: [Identification of protein markers for serum diagnosis of cancer based on microRNA expression profiling]. PMID: 21634125 Ref: Inhibition of miR-193a expression by Max and RXRalpha activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. PMID: 21670079 Ref: VEGFA gene locus (6p12) amplification identifies a small but highly aggressive subgroup of colorectal cancer [corrected] patients. PMID: 21743435 Ref: Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients. PMID: 21744990 Ref: JNK suppression is essential for 17beta-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. PMID: 21859479 Ref: [Transcriptomic regulation and molecular mechanism of polygenic tumor at different stages]. PMID: 21873780 Ref: Clinical relevance of uPA, uPAR, PAI 1 and PAI 2 tissue expression and plasma PAI 1 level in colorectal carcinoma patients. PMID: 22234062 |
Ref: Stromal cell-derived factor-1/CXC receptor 4 and beta1 integrin interaction regulates urokinase-type plasminogen activator expression in human colorectal cancer cells. PMID: 21567400 Ref: p38alpha MAPK mediates 17beta-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells. PMID: 22377968 Ref: Wnt/beta-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. PMID: 22550094 Ref: UCHL1 acts as a colorectal cancer oncogene via activation of the beta-catenin/TCF pathway through its deubiquitinating activity. PMID: 22641175 Ref: Sphingosine kinase 1 enhances colon cancer cell proliferation and invasion by upregulating the production of MMP-2/9 and uPA via MAPK pathways. PMID: 22684547 Ref: Role of plasminogen activator inhibitor-1 in urokinase's paradoxical in vivo tumor suppressing or promoting effects. PMID: 22912336 Ref: Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PMID: 22927998 |
Ref: Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab. PMID: 22956286 Ref: Evaluation of alpha 1-antitrypsin and the levels of mRNA expression of matrix metalloproteinase 7, urokinase type plasminogen activator receptor and COX-2 for the diagnosis of colorectal cancer. PMID: 23300952 Ref: ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304 Ref: Prognostic role of tumor-associated proteases in colorectal cancer. PMID: 23484202 Ref: Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion. PMID: 23485528 Ref: Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. PMID: 23668749 Ref: [Clinical prospects of tumor-associated proteases and their tissue inhibitors investigation in oncologic patient]. PMID: 24000664 Ref: Tumor associated proteases -- prognostic markers of colorectal cancer. PMID: 24640092 Ref: Human sprouty1 suppresses urokinase receptor-stimulated cell migration and invasion. PMID: 25937961 |
Ref: Impact of Phytolacca americana extracts on gene expression of colon cancer cells. PMID: 23553997 Ref: Glucose regulated protein 78 promotes cell invasion via regulation of uPA production and secretion in colon cancer cells. PMID: 24314144 Ref: Expression profiles of 507 proteins from a biotin label-based antibody array in human colorectal cancer. PMID: 24366523 Ref: TMPRSS4 induces cancer cell invasion through pro-uPA processing. PMID: 24434139 Ref: EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules. PMID: 24792576 Ref: Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells. PMID: 25132760 Ref: Characterization of the interaction between heterodimeric alphavbeta6 integrin and urokinase plasminogen activator receptor (uPAR) using functional proteomics. PMID: 25318615 Ref: A8, an anti-uPA agonistic antibody, promotes metastasis of cancer cells via ERK pathway. PMID: 25357998 Ref: Estradiol agonists inhibit human LoVo colorectal-cancer cell proliferation and migration through p53. PMID: 25469035 Ref: Effect of Bcl-xL gene expression silenced by RNA interference on invasion of human colorectal cancer cells. PMID: 25536597 |
Ref: Crude extract of Rheum palmatum L inhibits migration and invasion of LS1034 human colon cancer cells acts through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling. PMID: 24497447 Ref: Effect of Smad3/4 on chemotherapeutic drug sensitivity in colorectal cancer cells. PMID: 25370208 Ref: Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma. PMID: 25421538 Ref: Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency. PMID: 25679409 Ref: FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. PMID: 25962429 Ref: [Changes in markers of proliferation, neoangiogenesis and plasminogen activation system in rectal cancer tissue]. PMID: 25993872 Ref: Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor uPAR. PMID: 26040548 Ref: Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy. PMID: 26268716 Ref: ZEB1 and TCF4 reciprocally modulate their transcriptional activities to regulate Wnt target gene expression. PMID: 26387539 |
Ref: BMP pathway suppression is an early event in inflammation-driven colon neoplasmatogenesis of uPA-deficient mice. PMID: 26358253 Ref: Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. PMID: 26746659 Ref: Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion. PMID: 27391159 Ref: Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-kappaB, uPA activator and MMP9. PMID: 27895783 |
Ref: Tumor Budding, uPA, and PAI-1 in Colorectal Cancer: Update of a Prospective Study. PMID: 28286517 Ref: Targeted CDX2 expression inhibits aggressive phenotypes of colon cancer cells in vitro and in vivo. PMID: 28627695 Ref: Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors. PMID: 28839232 |
Ref: Up-regulation of miR-324-5p inhibits proliferation and invasion of colorectal cancer cells by targeting ELAVL1. PMID: 29386086 Ref: Molecular characterization of colorectal adenomas with and without malignancy reveals distinguishing genome, transcriptome and methylome alterations. PMID: 29453410 Ref: Anti-cancer effect of Aquaporin 5 silencing in colorectal cancer cells in association with inhibition of Wnt/beta-catenin pathway. PMID: 29455395 Ref: Novel Inhibitors of Urokinase-type Plasminogen Activators: 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-Substituted Benzamide and Benzamidine Compounds. PMID: 30112993 Ref: Bioinformatics Analysis Reveals Most Prominent Gene Candidates to Distinguish Colorectal Adenoma from Adenocarcinoma. PMID: 30175151 |