Primary Site >> Colorectal Cancer
Gene >> PKM
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Ref: Expression of hypoxia-inducible genes in tumor cells. PMID: 9692838 |
Ref: Clostridium difficile and enterotoxigenic Bacteroides fragilis strains isolated from patients with antibiotic associated diarrhoea. PMID: 16887705 |
Ref: Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers. PMID: 18097579 Ref: The database dbEST correctly predicts gene expression in colon cancer patients. PMID: 19075689 |
Ref: HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma. PMID: 20433702 |
Ref: Impact of butyrate on PKM2 and HSP90beta expression in human colon tissues of different transformation stages: a comparison of gene and protein data. PMID: 22009386 Ref: Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis. PMID: 22261915 Ref: miR-124, miR-137 and miR-340 regulate colorectal cancer growth via inhibition of the Warburg effect. PMID: 22895557 Ref: Targeting cancer metabolism. PMID: 23071355 |
Ref: Identification of stromal differentially expressed proteins in the colon carcinoma by quantitative proteomics. PMID: 23737015 |
Ref: The pro-apoptotic role of the regulatory feedback loop between miR-124 and PKM1/HNF4alpha in colorectal cancer cells. PMID: 24619225 Ref: Pyruvate kinase M2 facilitates colon cancer cell migration via the modulation of STAT3 signalling. PMID: 24686087 Ref: Overexpression of microRNA-122 re-sensitizes 5-FU-resistant colon cancer cells to 5-FU through the inhibition of PKM2 in vitro and in vivo. PMID: 24898807 Ref: PKM2 depletion induces the compensation of glutaminolysis through beta-catenin/c-Myc pathway in tumor cells. PMID: 25041845 Ref: ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. PMID: 25184678 Ref: Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. PMID: 25313085 |
Ref: Pyruvate kinase M2 accelerates pro-inflammatory cytokine secretion and cell proliferation induced by lipopolysaccharide in colorectal cancer. PMID: 25778902 Ref: Blood-based protein biomarker panel for the detection of colorectal cancer. PMID: 25793510 Ref: MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. PMID: 25818238 Ref: Significance of Polypyrimidine Tract-Binding Protein 1 Expression in Colorectal Cancer. PMID: 25904505 Ref: PKM2 Subcellular Localization Is Involved in Oxaliplatin Resistance Acquisition in HT29 Human Colorectal Cancer Cell Lines. PMID: 25955657 Ref: [Metabolism enzyme controls cancer stemness]. PMID: 25985625 Ref: Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells. PMID: 26144048 Ref: Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells. PMID: 26252736 Ref: Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. PMID: 26317652 Ref: Clinical Implication of Serine Metabolism-Associated Enzymes in Colon Cancer. PMID: 26439504 Ref: The impact of RNA binding motif protein 4-regulated splicing cascade on the progression and metabolism of colorectal cancer cells. PMID: 26506517 Ref: 5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits. PMID: 26527315 Ref: Nuclear PKM2 contributes to gefitinib resistance via upregulation of STAT3 activation in colorectal cancer. PMID: 26542452 Ref: Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value. PMID: 26617865 |
Ref: PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis. PMID: 26784545 Ref: A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1. PMID: 26860615 Ref: Identification of Predictive Markers for Response to Neoadjuvant Chemoradiation in Rectal Carcinomas by Proteomic Isotope Coded Protein Label (ICPL) Analysis. PMID: 26861291 Ref: The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. PMID: 26948869 Ref: PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors. PMID: 26980745 Ref: Exosomes in colorectal carcinoma formation: ALIX under the magnifying glass. PMID: 27150162 Ref: Insights into the potential of picoplanktonic marine cyanobacteria strains for cancer therapies - Cytotoxic mechanisms against the RKO colon cancer cell line. PMID: 27242042 Ref: Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer. PMID: 27323830 Ref: Perturbation of the Warburg effect increases the sensitivity of cancer cells to TRAIL-induced cell death. PMID: 27453209 Ref: TSC22D2 interacts with PKM2 and inhibits cell growth in colorectal cancer. PMID: 27573352 Ref: FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc. PMID: 27825133 |
Ref: Glycolysis gene expression analysis and selective metabolic advantage in the clinical progression of colorectal cancer. PMID: 26927284 Ref: Cross-Talk between Alternatively Spliced UGT1A Isoforms and Colon Cancer Cell Metabolism. PMID: 28049773 Ref: Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. PMID: 28423551 Ref: [Identification of the interacting proteins with S100A8 or S100A9 by affinity purification and mass spectrometry]. PMID: 28490692 Ref: Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells. PMID: 28498807 Ref: Effects of PKM2 Gene Silencing on the Proliferation and Apoptosis of Colorectal Cancer LS-147T and SW620 Cells. PMID: 28746922 Ref: Discovery and validation of a colorectal cancer classifier in a new blood test with improved performance for high-risk subjects. PMID: 28769740 Ref: PRL-3 improves colorectal cancer cell proliferation and invasion through IL-8 mediated glycolysis metabolism. PMID: 28791350 Ref: Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis. PMID: 28829588 Ref: A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth. PMID: 28985503 Ref: PKM2 is not required for colon cancer initiated by APC loss. PMID: 29214019 Ref: Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer. PMID: 29344170 |
Ref: Effect of HK2, PKM2 and LDHA on Cetuximab efficacy in metastatic colorectal cancer. PMID: 29552193 Ref: Immunotherapy of Colon Cancer. PMID: 29705788 Ref: Butyrate Suppresses the Proliferation of Colorectal Cancer Cells via Targeting Pyruvate Kinase M2 and Metabolic Reprogramming. PMID: 29739823 Ref: LncRNA-FEZF1-AS1 Promotes Tumor Proliferation and Metastasis in Colorectal Cancer by Regulating PKM2 Signaling. PMID: 29914894 Ref: Enhancing 5-fluorouracil efficacy through suppression of PKM2 in colorectal cancer cells. PMID: 30155759 Ref: PES1 is transcriptionally regulated by BRD4 and promotes cell proliferation and glycolysis in hepatocellular carcinoma. PMID: 30172011 Ref: PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis. PMID: 30219676 Ref: Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation. PMID: 30259036 Ref: SRSF3, a Splicer of the PKM Gene, Regulates Cell Growth and Maintenance of Cancer-Specific Energy Metabolism in Colon Cancer Cells. PMID: 30279379 Ref: LncRNA MAFG-AS1 promotes the progression of colorectal cancer by sponging miR-147b and activation of NDUFA4. PMID: 30348529 |