Primary Site >> Colorectal Cancer
Gene >> PDGFRB
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Ref: Expression of several growth factors and their receptor genes in human colon carcinomas. PMID: 1980764 |
Ref: Receptor tyrosine kinases expressed in metastatic colon cancer. PMID: 7896447 Ref: Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene. PMID: 7898930 |
Ref: Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. PMID: 9046331 |
Ref: Molecular changes during the genesis of human gliomas. PMID: 9407626 |
Ref: Biochemical and cellular effects of c-Src kinase-selective pyrido[2, 3-d]pyrimidine tyrosine kinase inhibitors. PMID: 10974196 |
Ref: Construction of tumor-specific cells expressing a membrane-anchored single-chain Fv of anti-ErbB-2 antibody. PMID: 11342269 Ref: Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. PMID: 11562278 |
Ref: Pleckstrin homology and phosphotyrosine-binding domain-dependent membrane association and tyrosine phosphorylation of Dok-4, an inhibitory adapter molecule expressed in epithelial cells. PMID: 14963042 Ref: Gene expression profiling of human colon xenograft tumors following treatment with SU11248, a multitargeted tyrosine kinase inhibitor. PMID: 14985702 |
Ref: Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume. PMID: 15466784 Ref: Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. PMID: 15705896 Ref: Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor. PMID: 15727903 Ref: In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. PMID: 15897558 |
Ref: Sunitinib: from rational design to clinical efficacy. PMID: 17327610 Ref: Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. PMID: 17641778 |
Ref: Targeting the EGFR, VEGFR, and PDGFR on colon cancer cells and stromal cells is required for therapy. PMID: 18324358 Ref: mRNA expression of platelet-derived growth factor receptor-beta and C-KIT: correlation with pathologic response to cetuximab-based chemoradiotherapy in patients with rectal cancer. PMID: 19028276 Ref: TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. PMID: 19047154 |
Ref: Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer. PMID: 19098285 |
Ref: Tyrosine kinase expression in pulmonary metastases and paired primary tumors. PMID: 19948538 Ref: Identification of key genes for carcinogenic pathways associated with colorectal adenoma-to-carcinoma progression. PMID: 20358421 Ref: Sunitinib deregulates tumor adaptation to hypoxia by inhibiting HIF-1alpha synthesis in HT-29 colon cancer cells. PMID: 20599738 Ref: Angiogenic cells, macroparticles and RNA transcripts in laparoscopic vs open surgery for colorectal cancer. PMID: 20676027 Ref: Novel potent orally active multitargeted receptor tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of 2-indolinone derivatives. PMID: 21028894 |
Ref: Dasatinib: an anti-tumour agent via Src inhibition. PMID: 21226671 Ref: Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors. PMID: 21670084 Ref: SKLB610: a novel potential inhibitor of vascular endothelial growth factor receptor tyrosine kinases inhibits angiogenesis and tumor growth in vivo. PMID: 21691074 Ref: Maintenance of adenomatous polyposis coli (APC)-mutant colorectal cancer is dependent on Wnt/beta-catenin signaling. PMID: 21949247 Ref: Antitumor activity of sorafenib in human cancer cell lines with acquired resistance to EGFR and VEGFR tyrosine kinase inhibitors. PMID: 22174910 Ref: Activation of PDGFr-beta Signaling Pathway after Imatinib and Radioimmunotherapy Treatment in Experimental Pancreatic Cancer. PMID: 24212821 |
Ref: Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13. PMID: 22076443 Ref: A phase I dose-escalation study of regorafenib (BAY 73-4506), an inhibitor of oncogenic, angiogenic, and stromal kinases, in patients with advanced solid tumors. PMID: 22421192 Ref: Regorafenib for cancer. PMID: 22577890 Ref: PDGFRalpha/beta and VEGFR2 polymorphisms in colorectal cancer: incidence and implications in clinical outcome. PMID: 23146028 |
Ref: Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer. PMID: 22821812 Ref: Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations. PMID: 23053743 Ref: A phase I trial of imatinib in combination with mFOLFOX6-bevacizumab in patients with advanced colorectal cancer. PMID: 23108698 Ref: Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis. PMID: 23188504 Ref: Regorafenib for gastrointestinal malignancies : from preclinical data to clinical results of a novel multi-target inhibitor. PMID: 23435872 Ref: PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells. PMID: 23441134 Ref: Blockade of the PDGFR family together with SRC leads to diminished proliferation of colorectal cancer cells. PMID: 23900414 |
Ref: Screening of hub genes and pathways in colorectal cancer with microarray technology. PMID: 24504536 Ref: Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis. PMID: 24687888 Ref: The prognostic value of the Na(+)/ H(+) exchanger regulatory factor 1 (NHERF1) protein in cancer. PMID: 24878819 Ref: Involvement of the CREB5 regulatory network in colorectal cancer metastasis. PMID: 25076032 Ref: Sunitinib mesylate inhibits proliferation of human colonic stromal fibroblasts in vitro and in vivo. PMID: 25091988 |
Ref: Genes involved in pericyte-driven tumor maturation predict treatment benefit of first-line FOLFIRI plus bevacizumab in patients with metastatic colorectal cancer. PMID: 25069475 Ref: A novel germline mutation of PDGFR-beta might be associated with clinical response of colorectal cancer to regorafenib. PMID: 25336117 Ref: Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia. PMID: 26206183 Ref: MicroRNA-219-5p functions as a tumor suppressor partially by targeting platelet-derived growth factor receptor alpha in colorectal cancer. PMID: 26458304 Ref: Molecular profiling of 6,892 colorectal cancer samples suggests different possible treatment options specific to metastatic sites. PMID: 26553611 Ref: Regorafenib: Antitumor Activity upon Mono and Combination Therapy in Preclinical Pediatric Malignancy Models. PMID: 26599335 |
Ref: EBI-907, a novel BRAF(V600E) inhibitor, has potent oral anti-tumor activity and a broad kinase selectivity profile. PMID: 26810733 Ref: Multikinase inhibitor regorafenib inhibits the growth and metastasis of colon cancer with abundant stroma. PMID: 26865419 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: Perivascular epithelioid cell tumor of the descending colon mimicking a gastrointestinal stromal tumor: a case report. PMID: 27842558 |
Ref: Potential actionable targets in appendiceal cancer detected by immunohistochemistry, fluorescent in situ hybridization, and mutational analysis. PMID: 28280620 Ref: A Novel Diagnostic Tool for Selecting Patients With Mesenchymal-Type Colon Cancer Reveals Intratumor Subtype Heterogeneity. PMID: 28376187 Ref: The potential role of nintedanib in treating colorectal cancer. PMID: 28649871 Ref: Targeted Delivery to Tumor-associated Pericytes via an Affibody with High Affinity for PDGFRbeta Enhances the in vivo Antitumor Effects of Human TRAIL. PMID: 28740549 Ref: Multi-parametric profiling of renal cell, colorectal, and ovarian cancer identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker. PMID: 28770105 Ref: Safety and efficacy of nintedanib for the treatment of metastatic colorectal cancer. PMID: 28965421 |
Ref: Anticancer evaluation and molecular modeling of multi-targeted kinase inhibitors based pyrido[2,3-d]pyrimidine scaffold. PMID: 29482389 Ref: Plateletderived growth factor receptorbeta gene expression relates to recurrence in colorectal cancer. PMID: 29498405 Ref: Expression of cancer-associated fibroblast markers in advanced colorectal cancer. PMID: 29616101 |