Primary Site >> Colorectal Cancer
Gene >> ODC1
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Ref: Ornithine decarboxylase activity in the rat and human colon. PMID: 6430547 Ref: Ornithine decarboxylase induction in rat colon: synergistic effects of intrarectal instillation of sodium deoxycholate and starvation-refeeding. PMID: 6693999 |
Ref: Prostaglandin E2 counteracts the inhibition by indomethacin of rat colon ornithine decarboxylase induction by deoxycholic acid. PMID: 3924707 Ref: Animal model for colorectal cancer. PMID: 4034597 |
Ref: Comparison of the effects of an ornithine decarboxylase inhibitor on the intestinal epithelium and on intestinal tumors. PMID: 3096554 Ref: Bile acids, ornithine decarboxylase, and cell proliferation in colon cancer: a review. PMID: 3545561 Ref: High ornithine decarboxylase activity and polyamine levels in human colorectal neoplasia. PMID: 3729588 Ref: Kinetic changes in mucosal ornithine decarboxylase activity during azoxymethane-induced colonic carcinogenesis in the rat. PMID: 3731101 |
Ref: The effects of a "low-risk" diet on cell proliferation and enzymatic parameters of preneoplastic rat colon. PMID: 2819830 Ref: Biochemical markers in patients with familial colonic neoplasia. PMID: 3035686 Ref: Effects of cyclosporine and alpha-difluoromethylornithine on the growth of mouse colon cancer in vitro. PMID: 3100897 Ref: Involvement of prostaglandin E2 in bile acid-caused promotion of colon carcinogenesis and anti-promotion by the cyclooxygenase inhibitor indomethacin. PMID: 3115924 Ref: Cyclosporine and alpha-difluoromethylornithine exhibit differential effects on colon and pancreatic cancer in vitro. PMID: 3117720 Ref: Systemic inhibition of tumor promoter-induced ornithine decarboxylase in 1 alpha-hydroxyvitamin D3-treated animals. PMID: 3621189 Ref: Expression of c-myb protooncogene and other cell cycle-related genes in normal and neoplastic human colonic mucosa. PMID: 3652034 |
Ref: Ornithine decarboxylase as a marker for colorectal polyps and cancer. PMID: 3054922 Ref: Biochemical markers in colorectal cancer: diagnostic and therapeutic implications. PMID: 3068151 Ref: Ornithine decarboxylase activity in hepatic and extrahepatic metastases from colorectal cancer. PMID: 3366033 Ref: Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia. PMID: 3411968 |
Ref: Ornithine decarboxylase activity as a biochemical marker in individuals predisposed to lung cancer. PMID: 2487240 Ref: Effects of timing of administration and dose of difluoromethylornithine on rat colonic carcinogenesis. PMID: 2493096 Ref: 2-Deoxy-D-glucose inhibits the antitumor effects of alpha-difluoromethylornithine on the growth of colon cancer in vivo. PMID: 2507471 Ref: [Antitumor effect of alpha-difluoromethylornithine (DFMO) changes in ornithine decarboxylase (ODC) activity and polyamine (PA) levels in human tumor transplanted into nude mice]. PMID: 2507897 Ref: Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells. PMID: 2511847 Ref: [The influence of theophylline on polyamine metabolism and colonic carcinogenesis induced by 1.2-dimethylhydrazine in mice]. PMID: 2593308 Ref: Attenuation of azoxymethane-induced colonic mucosal ornithine decarboxylase and tyrosine kinase activity by calcium in rats. PMID: 2790802 Ref: [A study of ornithine decarboxylase activity in tumor tissue and rectal mucosa in patients with colorectal cancer or adenoma]. PMID: 2795955 |
Ref: Increased levels of phorbin, c-myc, and ornithine decarboxylase RNAs in human colon cancer. PMID: 1693276 Ref: Colonic polyamine content and ornithine decarboxylase activity as markers for adenomas. PMID: 2208006 Ref: Polyamine uptake by human colon carcinoma cell line CaCo-2. PMID: 2262067 Ref: Absence of effect of supplemental oral calcium on ornithine decarboxylase (ODC) activity in colonic mucosae of healthy individuals with a family history of colorectal cancer. PMID: 2304344 Ref: Changes in intestinal function of rats initiated with DMH and fed varying levels of butterfat, calcium, and magnesium. PMID: 2308874 Ref: Properties of ornithine decarboxylase in human colorectal adenocarcinomas. PMID: 2317797 Ref: Effect of different levels of calorie restriction on azoxymethane-induced colon carcinogenesis in male F344 rats. PMID: 2393850 Ref: Flavone acetic acid suppresses human peripheral blood lymphocyte and human colonic lamina propria lymphocyte DNA synthesis. PMID: 2394038 |
Ref: Involvement of ornithine decarboxylase in the control of proliferation of the HT29 human colon cancer cell line. Effect of vasoactive intestinal peptide on enzyme activity. PMID: 1847359 Ref: Differential sensitivity of various human tumors to inhibition of polyamine biosynthesis in vivo. PMID: 1985877 Ref: Influence of gastrin, gastrin receptor blockers, epidermal growth factor, and difluoromethylornithine on the growth and the activity of ornithine decarboxylase of colonic carcinoma cells. PMID: 1997467 Ref: Heterogenicity of ornithine decarboxylase during mouse colon carcinogenesis and in human colon tumors. PMID: 2009526 Ref: Effect of oltipraz [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] on azoxymethane-induced biochemical changes related to early colon carcinogenesis in male F344 rats. PMID: 2020672 Ref: Colorectal ornithine decarboxylase activity in human mucosa and tumors: elevation of enzymatic activity in distal mucosa. PMID: 2062082 |
Ref: Induction of ornithine decarboxylase in normal and protein kinase C--depleted human colon carcinoma cells. PMID: 1294268 Ref: Effect of chemopreventive agents on intermediate biomarkers during different stages of azoxymethane-induced colon carcinogenesis. PMID: 1305473 Ref: Levels of colorectal ornithine decarboxylase activity in patients with colon cancer, a family history of nonpolyposis hereditary colorectal cancer, and adenomas. PMID: 1306105 Ref: Effects of vasoactive intestinal peptide on adenosine 3',5'-monophosphate, ornithine decarboxylase, and cell growth in a human colon cell line. PMID: 1324153 Ref: A protective role of 1,25-dihydroxyvitamin D3 in chemically induced rat colon carcinogenesis. PMID: 1335376 Ref: Sodium butyrate stimulates polyamine biosynthesis in colon cancer cells. PMID: 1341266 Ref: Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA. PMID: 1451976 Ref: Effects of short-chain fatty acids on growth and differentiation of the human colon-cancer cell line HT29. PMID: 1521915 Ref: Polyamine levels, ornithine decarboxylase (ODC) activity, and ODC-mRNA expression in normal and cancerous human colonocytes. PMID: 1573975 Ref: Multiple promoter elements govern expression of the human ornithine decarboxylase gene in colon carcinoma cells. PMID: 1598217 Ref: Effect of the chemopreventive agents piroxicam and D,L-alpha-difluoromethylornithine on intermediate biomarkers of colon carcinogenesis. PMID: 1600622 |
Ref: Selenium and difluoromethylornithine additively inhibit DMH-induced distal colon tumor formation in rats fed a fiber-free diet. PMID: 8242864 Ref: Persistence of the circadian variation and altered response to hepatectomy of hepatic ornithine decarboxylase activity with malignant tumor burden. PMID: 8324645 Ref: beta-Carotene inhibits rectal mucosal ornithine decarboxylase activity in colon cancer patients. PMID: 8339282 Ref: Ornithine decarboxylase and polyamines in colorectal neoplasia and mucosa. PMID: 8348060 Ref: Polyamines, diamine oxidase, and ornithine decarboxylase activity in colorectal cancer and in normal surrounding mucosa. PMID: 8348850 Ref: Inhibitory effect of caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci formation in rat colon. PMID: 8364913 Ref: Effects of gastrin and difluoromethylornithine on growth of human colon cancer. PMID: 8444085 Ref: Randomized phase I chemoprevention dose-seeking study of alpha-difluoromethylornithine. PMID: 8478959 |
Ref: Relationship of ornithine decarboxylase activity and human colon tumorigenesis. PMID: 8007423 Ref: Ornithine decarboxylase (ODC) levels in children with reflux esophagitis. PMID: 8149836 |
Ref: Chlorpheniramine inhibits the synthesis of ornithine decarboxylase and the proliferation of human breast cancer cell lines. PMID: 7647340 Ref: Hypergastrinemia in rats with azoxymethane-induced colon cancers. PMID: 7705952 Ref: Chemopreventive effects of calcium but not aspirin supplementation in cholic acid-promoted colon carcinogenesis: correlation with intermediate endpoints. PMID: 7728952 Ref: Immunohistochemical staining and activity of ornithine decarboxylase in colorectal cancer. PMID: 7750083 Ref: Development of difluoromethylornithine as a chemoprevention agent for the management of colon cancer. PMID: 8538189 Ref: Polyphenols as cancer chemopreventive agents. PMID: 8538195 Ref: Ornithine decarboxylase and tyrosine kinase activity in juvenile polyps of childhood. PMID: 8559612 Ref: Association between high levels of ornithine decarboxylase activity and favorable prognosis in human colorectal carcinoma. PMID: 9816030 |
Ref: Androgen induces ornithine decarboxylase gene expression in colonic cell line HT-29. PMID: 8878500 Ref: Dissimilar activation patterns of the carcinogen dimethylhydrazine (DMH) on intracellular polyamine metabolism in various organs. PMID: 9017896 |
Ref: Ornithine decarboxylase and polyamines in familial adenomatous polyposis. PMID: 9000553 Ref: Analysis of ornithine decarboxylase messenger ribonucleic acid expression in colorectal carcinoma. PMID: 9293942 |
Ref: Inhibition of cell growth in CaCO2 cells by the polyamine analogue N1,N12-bis(ethyl)spermine is preceded by a reduction in MYC oncoprotein levels. PMID: 9462700 Ref: Differential inhibitory effects of three nitric oxide donors on ornithine decarboxylase activity in human colon carcinoma cells. PMID: 9719478 Ref: Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells. PMID: 9719479 Ref: Point mutations of ornithine decarboxylase gene are an infrequent event in colorectal cancer but a missense mutation was found in a replication error positive patient with hMSH2 germline mutation. PMID: 9730154 Ref: NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms. PMID: 9756558 Ref: Phase I chemoprevention study of piroxicam and alpha-difluoromethylornithine. PMID: 9796636 Ref: A randomized, placebo-controlled trial of low-dose alpha-difluoromethylornithine in individuals at risk for colorectal cancer. PMID: 9829706 Ref: S-adenosylmethionine decarboxylase activity and utilization of exogenous putrescine are enhanced in colon cancer cells stimulated to grow by EGF. PMID: 9880821 Ref: Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies. PMID: 9924288 |
Ref: Increased colonic ornithine decarboxylase activity in inflammatory bowel disease in children. PMID: 10492133 |
Ref: Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment of Apc mutant Min mouse adenomas, and selective toxicity against Apc mutant embryos. PMID: 10766173 Ref: Low-dose deoxycholic acid stimulates putrescine uptake in colon cancer cells (Caco-2). PMID: 10806308 Ref: EGF-stimulated polyamine accumulation in the colon carcinoma cell line, Caco-2. PMID: 10878449 Ref: Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells. PMID: 10940513 |
Ref: A retro-inverso peptide homologous to helix 1 of c-Myc is a potent and specific inhibitor of proliferation in different cellular systems. PMID: 11099487 Ref: Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth. PMID: 11163334 Ref: Use of a modified ornithine decarboxylase promoter to achieve efficient c-MYC- or N-MYC-regulated protein expression. PMID: 11306486 Ref: Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats. PMID: 11346461 Ref: PPAR-gamma ligands inhibit growth of human esophageal adenocarcinoma cells through induction of apoptosis, cell cycle arrest and reduction of ornithine decarboxylase activity. PMID: 11494023 Ref: Expression of putative anticancer targets in familial adenomatous polyposis and its association with the APC mutation status. PMID: 11713587 Ref: Nonsteroidal anti-inflammatory drugs stimulate spermidine/spermine acetyltransferase and deplete polyamine content in colon cancer cells. PMID: 11737227 Ref: Role of putrescine in cell proliferation in a colon carcinoma cell line. PMID: 11744344 |
Ref: APC-dependent regulation of ornithine decarboxylase in human colon tumor cells. PMID: 12112318 Ref: Genetic alterations of the ornithine decarboxylase gene in human colorectal cancers. PMID: 12148577 Ref: DNA microarray technology reveals similar gene expression patterns in rats with vitamin a deficiency and chemically induced colitis. PMID: 12163651 Ref: Gut-enriched Kruppel-like factor represses ornithine decarboxylase gene expression and functions as checkpoint regulator in colonic cancer cells. PMID: 12297499 |
Ref: Polyamine metabolism in primary human colon adenocarcinoma cells (SW480) and their lymph node metastatic derivatives (SW620). PMID: 12624736 Ref: Polyamines as modifiers of genetic risk factors in human intestinal cancers. PMID: 12653645 Ref: Cloning and expression of ornithine decarboxylase gene from human colorectal carcinoma. PMID: 12679917 Ref: Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene. PMID: 12810952 Ref: Genetic and biochemical changes in colorectal carcinoma in relation to morphologic characteristics. PMID: 14534731 Ref: Apoptotic response to 5-fluorouracil treatment is mediated by reduced polyamines, non-autocrine Fas ligand and induced tumor necrosis factor receptor 2. PMID: 14614330 Ref: Inhibition of human colon carcinoma cell growth by ammonia: a non-cytotoxic process associated with polyamine synthesis reduction. PMID: 14642818 |
Ref: The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells. PMID: 15057874 Ref: Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma. PMID: 15180186 Ref: Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in colorectal cancer: key role of polyamines? PMID: 15570015 |
Ref: Ornithine decarboxylase gene is overexpressed in colorectal carcinoma. PMID: 15818733 Ref: Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors. PMID: 15918191 Ref: Effects of agmatine accumulation in human colon carcinoma cells on polyamine metabolism, DNA synthesis and the cell cycle. PMID: 16085059 Ref: Effects of genistein on the polyamine metabolism and cell growth in DLD-1 human colon cancer cells. PMID: 16091008 Ref: A comprehensive strategy to combat colon cancer targeting the adenomatous polyposis coli tumor suppressor gene. PMID: 16382048 |
Ref: Chemopreventive effect of protein extract of Asterina pectinifera in HT-29 human colon adenocarcinoma cells. PMID: 16596993 Ref: Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. PMID: 16783835 Ref: Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer. PMID: 16854216 Ref: Lentiviral vector-mediated downregulation of ornithine decarboxylase inhibits tumor cell growth in vitro and in vivo. PMID: 16888408 Ref: Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. PMID: 16898869 Ref: Adenovirus-mediated expression of both antisense ornithine decarboxylase and s-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells. PMID: 17129409 |
Ref: Exercise associated genes in rat colon mucosa: upregulation of ornithin decarboxylase-1. PMID: 17111318 Ref: Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventive agent. PMID: 17371277 Ref: De novo ceramide biosynthesis is associated with resveratrol-induced inhibition of ornithine decarboxylase activity. PMID: 17521618 Ref: Ornithine decarboxylase activity as a prognostic marker for colorectal cancer. PMID: 17957960 Ref: Chemopreventive effect of chitosan oligosaccharide against colon carcinogenesis. PMID: 18062235 Ref: L-arginine reduces cell proliferation and ornithine decarboxylase activity in patients with colorectal adenoma and adenocarcinoma. PMID: 18094424 |
Ref: Antitumor activity of new substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and 3-(5-imidazo[2,1-b]thiadiazolylmethylene)-2-indolinones: selectivity against colon tumor cells and effect on cell cycle-related events. PMID: 19006285 |
Ref: Methylation status of CpG islands in the promoter region of genes differentially expressed in colonic mucosa from adenoma patients and controls in response to altered vegetable intake. PMID: 19434801 Ref: Chemopreventive effects of polysaccharides extract from Asterina pectinifera on HT-29 human colon adenocarcinoma cells. PMID: 19470241 Ref: Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival. PMID: 19789310 Ref: Polyamines as mediators of APC-dependent intestinal carcinogenesis and cancer chemoprevention. PMID: 20095973 |
Ref: Targeted antitumor effect induced by hTERT promoter mediated ODC antisense adenovirus. PMID: 19876766 Ref: Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-beta/Smad signaling pathway. PMID: 20603835 |
Ref: Ornithine decarboxylase G316A genotype and colorectal cancer risk. PMID: 20456464 Ref: Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice. PMID: 21464038 Ref: The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells. PMID: 21500097 |
Ref: Polyamine depletion enhances the roscovitine-induced apoptosis through the activation of mitochondria in HCT116 colon carcinoma cells. PMID: 21809075 Ref: The influence of 5-aminosalicylic acid on the progression of colorectal adenomas via the beta-catenin signaling pathway. PMID: 22198215 Ref: Ellagic acid modulates antioxidant status, ornithine decarboxylase expression, and aberrant crypt foci progression in 1,2-dimethylhydrazine-instigated colon preneoplastic lesions in rats. PMID: 22439659 Ref: Meat consumption, ornithine decarboxylase gene polymorphism, and outcomes after colorectal cancer diagnosis. PMID: 23233821 |
Ref: Polyamine and methionine adenosyltransferase 2A crosstalk in human colon and liver cancer. PMID: 23588207 |
Ref: Immunohistochemical expression of ornithine decarboxylase, diamine oxidase, putrescine, and spermine in normal canine enterocolic mucosa, in chronic colitis, and in colorectal cancer. PMID: 26550563 |
Ref: Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. PMID: 26676750 Ref: The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPbeta rather than Enterotoxigenic Bacteroides fragilis Infection. PMID: 27433286 Ref: Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial. PMID: 27480131 Ref: Macrophages induce resistance to 5-fluorouracil chemotherapy in colorectal cancer through the release of putrescine. PMID: 27514455 |
Ref: Apigenin Inhibits Human SW620 Cell Growth by Targeting Polyamine Catabolism. PMID: 28572828 |
Ref: Alpha-Difluoromethylornithine, an Irreversible Inhibitor of Polyamine Biosynthesis, as a Therapeutic Strategy against Hyperproliferative and Infectious Diseases. PMID: 29419804 Ref: Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. PMID: 29853605 Ref: Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies. PMID: 30138353 Ref: Effects of berberine on tumor growth and intestinal permeability in HCT116 tumor-bearing mice using polyamines as targets. PMID: 30257361 |