Primary Site >> Colorectal Cancer
Gene >> NTN1
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Ref: Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. PMID: 8861902 |
Ref: Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. PMID: 9126737 Ref: Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia. PMID: 9331350 Ref: Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. PMID: 9334332 |
Ref: The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. PMID: 9796814 |
Ref: Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. PMID: 9950216 Ref: Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons. PMID: 10341242 Ref: Divergent properties of mouse netrins. PMID: 10381568 Ref: Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice. PMID: 10559399 Ref: Extension of long leading processes and neuronal migration in the mammalian brain directed by the chemoattractant netrin-1. PMID: 10595513 |
Ref: Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. PMID: 11048721 |
Ref: A role of netrin-1 in the formation of the subcortical structure striatum: repulsive action on the migration of late-born striatal neurons. PMID: 11404412 |
Ref: The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. PMID: 11817894 Ref: Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells. PMID: 11844789 Ref: Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration. PMID: 11927147 Ref: Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation. PMID: 11986622 Ref: Directional guidance of oligodendroglial migration by class 3 semaphorins and netrin-1. PMID: 12122061 Ref: The adaptor protein Nck-1 couples the netrin-1 receptor DCC (deleted in colorectal cancer) to the activation of the small GTPase Rac1 through an atypical mechanism. PMID: 12149262 Ref: Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation. PMID: 12351186 Ref: Where the rubber meets the road: netrin expression and function in developing and adult nervous systems. PMID: 12440385 |
Ref: Quantification of expression of netrins, slits and their receptors in human prostate tumors. PMID: 12471613 Ref: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. PMID: 12655055 Ref: Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord. PMID: 12736344 Ref: Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas. PMID: 12798294 Ref: Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. PMID: 12819897 Ref: The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival. PMID: 14597260 |
Ref: Netrin 1-mediated chemoattraction regulates the migratory pathway of LHRH neurons. PMID: 14750959 Ref: Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: A novel mechanism regulating commissural axon extension. PMID: 15044543 Ref: Role of the dependence receptor DCC in colorectal cancer pathogenesis. PMID: 15310786 Ref: Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. PMID: 15343335 Ref: Focal adhesion kinase in netrin-1 signaling. PMID: 15494733 Ref: Netrin-1 and its receptors in tumorigenesis. PMID: 15573119 |
Ref: Localization of immunoreactivity for deleted in colorectal cancer (DCC), the receptor for the guidance factor netrin-1, in ventral tier dopamine projection pathways in adult rodents. PMID: 15730872 Ref: Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion. PMID: 15788770 Ref: DCC association with lipid rafts is required for netrin-1-mediated axon guidance. PMID: 15811950 Ref: Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers. PMID: 15956977 Ref: [Netrin-1 and its dependence receptors: role in colorectal cancers]. PMID: 16004944 Ref: Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis. PMID: 16158190 Ref: Netrin induces down-regulation of its receptor, Deleted in Colorectal Cancer, through the ubiquitin-proteasome pathway in the embryonic cortical neuron. PMID: 16181408 Ref: Molecular mechanisms of optic axon guidance. PMID: 16220285 Ref: Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth. PMID: 16244667 Ref: [Dependence receptors DCC and UNC5H: the role of apoptosis in the control of tumorigenesis]. PMID: 16471261 |
Ref: DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation. PMID: 16321979 Ref: Enhanced expression of netrin-1 protein in the sciatic nerves of Lewis rats with experimental autoimmune neuritis: possible role of the netrin-1/DCC binding pathway in an autoimmune PNS disorder. PMID: 16337279 Ref: The dependence receptor DCC requires lipid raft localization for cell death signaling. PMID: 16537496 Ref: Protein interacting with C-kinase 1/protein kinase Calpha-mediated endocytosis converts netrin-1-mediated repulsion to attraction. PMID: 16554470 Ref: DCC regulates cell adhesion in human colon cancer derived HT-29 cells and associates with ezrin. PMID: 16762451 Ref: Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut. PMID: 16917820 Ref: Deleted in colorectal cancer is a putative conditional tumor-suppressor gene inactivated by promoter hypermethylation in head and neck squamous cell carcinoma. PMID: 17018594 |
Ref: Myosin X regulates netrin receptors and functions in axonal path-finding. PMID: 17237772 Ref: Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis. PMID: 17334389 Ref: [Netrin-1 and axonal guidance: signaling and asymmetrical translation]. PMID: 17349294 Ref: Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate. PMID: 17442818 Ref: Dependence receptors: when apoptosis controls tumor progression. PMID: 17449433 Ref: Expression of netrin-1 and its receptors DCC and neogenin in rat brain after ischemia. PMID: 17574219 Ref: Pontine tegmental cap dysplasia: a novel brain malformation with a defect in axonal guidance. PMID: 17690130 Ref: Netrin-1 induces proliferation of Schwann cells through Unc5b receptor. PMID: 17825258 Ref: Netrins and their receptors. PMID: 18269208 |
Ref: Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance. PMID: 18212043 Ref: Tyrosine phosphorylation of netrin receptors in netrin-1 signaling. PMID: 18253061 Ref: Laminin terminates the Netrin/DCC mediated attraction of vagal sensory axons. PMID: 18418846 Ref: Netrin-1 inhibits sprouting angiogenesis in developing avian embryos. PMID: 18439993 Ref: Netrin-1 and its receptors in tumour growth promotion. PMID: 18620521 Ref: Depolarization recruits DCC to the plasma membrane of embryonic cortical neurons and enhances axon extension in response to netrin-1. PMID: 18691385 Ref: NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors. PMID: 18692059 Ref: LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin. PMID: 18702663 Ref: Netrin-1 is a survival factor during commissural neuron navigation. PMID: 18796601 Ref: Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor. PMID: 18922894 Ref: Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1. PMID: 18945908 Ref: Netrin-1 specifically enhances cell spreading on fibronectin in human glioblastoma cells. PMID: 19967060 |
Ref: Compartmentalized DCC signalling is distinct from DCC localized to lipid rafts. PMID: 18616430 Ref: Interference with netrin-1 and tumor cell death in non-small cell lung cancer. PMID: 19211441 Ref: Netrin-1 increases proliferation and migration of renal proximal tubular epithelial cells via the UNC5B receptor. PMID: 19211685 Ref: Segment-specific expression of netrin-1 receptors in normal and ischemic mouse kidney. PMID: 19372643 Ref: Interfering with multimerization of netrin-1 receptors triggers tumor cell death. PMID: 19543238 Ref: Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression. PMID: 19721007 Ref: Role of deleted in colon carcinoma in osteoarthritis and in chondrocyte migration. PMID: 19745029 |
Ref: The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality. PMID: 19858080 Ref: Netrin-1 and its dependence receptors as original targets for cancer therapy. PMID: 19934758 Ref: Netrin-1 elevates the level and induces cluster formation of its receptor DCC at the surface of cortical axon shafts in an exocytosis-dependent manner. PMID: 20170691 Ref: Netrin-1, a missing link between chronic inflammation and tumor progression. PMID: 20305387 Ref: Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. PMID: 20345916 Ref: A central role for RhoA during oligodendroglial maturation in the switch from netrin-1-mediated chemorepulsion to process elaboration. PMID: 20367748 Ref: Critical roles for the netrin receptor deleted in colorectal cancer in dopaminergic neuronal precursor migration, axon guidance, and axon arborization. PMID: 20493932 Ref: Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development. PMID: 20609112 Ref: Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents. PMID: 20628609 Ref: Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. PMID: 20693423 |
Ref: Plasma netrin-1 is a diagnostic biomarker of human cancers. PMID: 21303223 Ref: Novel roles for Slits and netrins: axon guidance cues as anticancer targets? PMID: 21326323 Ref: Abolition of the behavioral phenotype of adult netrin-1 receptor deficient mice by exposure to amphetamine during the juvenile period. PMID: 21523346 Ref: Spatial and temporal second messenger codes for growth cone turning. PMID: 21795610 Ref: Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia. PMID: 21820492 Ref: The activation of ezrin-radixin-moesin proteins is regulated by netrin-1 through Src kinase and RhoA/Rho kinase activities and mediates netrin-1-induced axon outgrowth. PMID: 21849478 Ref: Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation. PMID: 21980448 Ref: A signaling mechanism coupling netrin-1/deleted in colorectal cancer chemoattraction to SNARE-mediated exocytosis in axonal growth cones. PMID: 21994363 |
Ref: Netrin-1 simultaneously suppresses corneal inflammation and neovascularization. PMID: 22323486 Ref: Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours. PMID: 22358843 Ref: Association between schizophrenia and genetic variation in DCC: a case-control study. PMID: 22418395 Ref: Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1. PMID: 22512716 Ref: Increased expression of netrin-1 and its deleted in colorectal cancer receptor in human diseased lumbar intervertebral disc compared with autopsy control. PMID: 22588384 Ref: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. PMID: 22685302 Ref: TNF-alpha mediates macrophage-induced bystander effects through Netrin-1. PMID: 22915753 Ref: Netrin-1 in the developing enteric nervous system and colorectal cancer. PMID: 22920895 Ref: Syntaxin 1 is required for DCC/Netrin-1-dependent chemoattraction of migrating neurons from the lower rhombic lip. PMID: 22946563 |
Ref: c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance. PMID: 23223444 Ref: Tyrosine phosphorylation of the Rho guanine nucleotide exchange factor Trio regulates netrin-1/DCC-mediated cortical axon outgrowth. PMID: 23230270 Ref: Netrin-1 rescues neuron loss by attenuating secondary apoptosis in ipsilateral thalamic nucleus following focal cerebral infarction in hypertensive rats. PMID: 23232257 Ref: DCC expression by neurons regulates synaptic plasticity in the adult brain. PMID: 23291093 Ref: Netrin-1 protects hypoxia-induced mitochondrial apoptosis through HSP27 expression via DCC- and integrin alpha6beta4-dependent Akt, GSK-3beta, and HSF-1 in mesenchymal stem cells. PMID: 23538444 Ref: Netrin-1 receptor-deficient mice show age-specific impairment in drug-induced locomotor hyperactivity but still self-administer methamphetamine. PMID: 23820928 Ref: Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury. PMID: 25206373 |
Ref: Piezoelectric ceramic (PZT) modulates axonal guidance growth of rat cortical neurons via RhoA, Rac1, and Cdc42 pathways. PMID: 24203571 Ref: Netrin-1 as a potential target for metastatic cancer: focus on colorectal cancer. PMID: 24338005 Ref: Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor. PMID: 24400119 Ref: Netrin-1 induces epithelial-mesenchymal transition and promotes hepatocellular carcinoma invasiveness. PMID: 24442237 Ref: Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. PMID: 24876346 Ref: Netrin-1 controls sympathetic arterial innervation. PMID: 24937433 Ref: Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes. PMID: 25031414 Ref: The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue. PMID: 25123307 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 |
Ref: Netrin-1 improves post-injury cardiac function in vivo via DCC/NO-dependent preservation of mitochondrial integrity, while attenuating autophagy. PMID: 24928309 Ref: Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. PMID: 25561546 Ref: Coordinated interaction of Down syndrome cell adhesion molecule and deleted in colorectal cancer with dynamic TUBB3 mediates Netrin-1-induced axon branching. PMID: 25754961 Ref: Signaling mechanism of the netrin-1 receptor DCC in axon guidance. PMID: 25881791 Ref: Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PMID: 25950802 Ref: Netrin-1 exerts oncogenic activities through enhancing Yes-associated protein stability. PMID: 26039999 Ref: Resilience to amphetamine in mouse models of netrin-1 haploinsufficiency: role of mesocortical dopamine. PMID: 26264903 Ref: Netrin-1 overexpression in bone marrow mesenchymal stem cells promotes functional recovery in a rat model of peripheral nerve injury. PMID: 26445571 Ref: Operational redundancy in axon guidance through the multifunctional receptor Robo3 and its ligand NELL2. PMID: 26586761 |
Ref: Netrin-1 is highly expressed and required in inflammatory infiltrates in wear particle-induced osteolysis. PMID: 26452536 Ref: Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain. PMID: 26482371 Ref: Netrin-1 induces local translation of down syndrome cell adhesion molecule in axonal growth cones. PMID: 26518186 Ref: p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance. PMID: 26710849 Ref: Direct measurement of oscillatory RhoA activity in embryonic cortical neurons stimulated with the axon guidance cue netrin-1 using fluorescence resonance energy transfer. PMID: 26787017 Ref: Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas. PMID: 26882243 Ref: Neuronal Cell Bodies Remotely Regulate Axonal Growth Response to Localized Netrin-1 Treatment via Second Messenger and DCC Dynamics. PMID: 28105005 |
Ref: Lentiviral-Mediated Netrin-1 Overexpression Improves Motor and Sensory Functions in SCT Rats Associated with SYP and GAP-43 Expressions. PMID: 26873853 Ref: Role of Netrin-1 Signaling in Nerve Regeneration. PMID: 28245592 Ref: Netrin-1 in cancer: Potential biomarker and therapeutic target? PMID: 28443497 Ref: Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats. PMID: 28526701 Ref: Spatially Selective Dissection of Signal Transduction in Neurons Grown on Netrin-1 Printed Nanoarrays via Segmented Fluorescence Fluctuation Analysis. PMID: 28679208 Ref: TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching. PMID: 28701345 Ref: Effects of intra-arterial transplantation of adipose-derived stem cells on the expression of netrin-1 and its receptor DCC in the peri-infarct cortex after experimental stroke. PMID: 29017609 Ref: Making Dopamine Connections in Adolescence. PMID: 29032842 Ref: Shift in the function of netrin-1 from axon outgrowth to axon branching in developing cerebral cortical neurons. PMID: 29041904 Ref: Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats. PMID: 29375318 |
Ref: DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome. PMID: 29068161 Ref: DCC/NTN1 complex mutations in patients with congenital hypogonadotropic hypogonadism impair GnRH neuron development. PMID: 29202173 Ref: Carboxylated graphene oxide promoted axonal guidance growth by activating Netrin-1/deleted in colorectal cancer signaling in rat primary cultured cortical neurons. PMID: 29377591 Ref: Human TUBB3 Mutations Disrupt Netrin Attractive Signaling. PMID: 29382549 Ref: The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction. PMID: 29479476 Ref: Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. PMID: 29503192 Ref: Protective Effect of Moderate Exogenous Electric Field Stimulation on Activating Netrin-1/DCC Expression Against Mechanical Stretch-Induced Injury in Spinal Cord Neurons. PMID: 29627918 Ref: Revisiting Netrin-1: One Who Guides (Axons). PMID: 30108487 Ref: Netrin-1/DCC-mediated PLCgamma1 activation is required for axon guidance and brain structure development. PMID: 30224412 |