Primary Site >> Biliary tract Cancer
Gene >> NR1H4
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Ref: beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. PMID: 18772362 |
Ref: Genetic factors in the pathogenesis of cholangiocarcinoma. PMID: 21691113 |
Ref: MicroRNA-421 functions as an oncogenic miRNA in biliary tract cancer through down-regulating farnesoid X receptor expression. PMID: 22146319 |
Ref: Inhibition of SCAMP1 suppresses cell migration and invasion in human pancreatic and gallbladder cancer cells. PMID: 23653380 |
Ref: Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development. PMID: 24255171 Ref: Expressions of farnesoid X receptor and myeloid cell leukemia sequence 1 protein are associated with poor prognosis in patients with gallbladder cancer. PMID: 25043081 Ref: Bile canalicular changes and defective bile secretion in Opisthorchis viverrini-infected hamsters. PMID: 25651692 |
Ref: Nuclear receptor variants in liver disease. PMID: 26045277 |
Ref: FXR agonists enhance the sensitivity of biliary tract cancer cells to cisplatin via SHP dependent inhibition of Bcl-xL expression. PMID: 27127878 Ref: RNA sequencing-based analysis of gallbladder cancer reveals the importance of the liver X receptor and lipid metabolism in gallbladder cancer. PMID: 27167107 |
Ref: Bile acid receptors in the biliary tree: TGR5 in physiology and disease. PMID: 28844960 Ref: Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression. PMID: 28916388 Ref: Reduced triglyceride accumulation due to overactivation of farnesoid X receptor signaling contributes to impaired liver regeneration following 50% hepatectomy in extracholestatic liver tissue. PMID: 29138817 Ref: FXR Acts as a Metastasis Suppressor in Intrahepatic Cholangiocarcinoma by Inhibiting IL-6-Induced Epithelial-Mesenchymal Transition. PMID: 30001540 |