Primary Site >> Colorectal Cancer
Gene >> NOX1
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Ref: NADPH oxidase subunit, gp91(phox) homologue, preferentially expressed in human colon epithelial cells. PMID: 10974555 |
Ref: Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. PMID: 14978110 |
Ref: Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon. PMID: 15797632 Ref: Expression of NOX1, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease. PMID: 16086438 |
Ref: Nox1 downstream of 12-lipoxygenase controls cell proliferation but not cell spreading of colon cancer cells. PMID: 18076063 Ref: Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras. PMID: 18398843 Ref: Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. PMID: 18454176 Ref: NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. PMID: 18454179 Ref: The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1. PMID: 18463161 Ref: Activation of NADPH oxidase 1 in tumour colon epithelial cells. PMID: 18518859 Ref: Tumor necrosis factor alpha activates transcription of the NADPH oxidase organizer 1 (NOXO1) gene and upregulates superoxide production in colon epithelial cells. PMID: 18929641 |
Ref: Modulation of cellular redox state underlies antagonism between oxaliplatin and cetuximab in human colorectal cancer cell lines. PMID: 19732064 Ref: Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. PMID: 19755710 |
Ref: A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. PMID: 20715845 Ref: c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. PMID: 20943948 Ref: Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1) PMID: 22834042 |
Ref: NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). PMID: 20715105 Ref: Endogenous production of reactive oxygen species by the NADPH oxidase complexes is a determinant of gamma-glutamyltransferase expression. PMID: 21381898 |
Ref: A crucial role for Nox 1 in redox-dependent regulation of Wnt-beta-catenin signaling. PMID: 22278940 Ref: Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel. PMID: 22305747 Ref: Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/beta-catenin signaling pathway. PMID: 22552367 Ref: TLR-4 signalling accelerates colon cancer cell adhesion via NF-kappaB mediated transcriptional up-regulation of Nox-1. PMID: 23071493 |
Ref: Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line. PMID: 23092829 Ref: Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts. PMID: 23314043 Ref: Association of Nox1 and vinculin with colon cancer progression. PMID: 23627409 Ref: Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. PMID: 24187133 |
Ref: Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice. PMID: 25014110 Ref: Predictive gene signatures: molecular markers distinguishing colon adenomatous polyp and carcinoma. PMID: 25423035 |
Ref: Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines. PMID: 25483731 Ref: Involvement of NADPH oxidases in suppression of cyclooxygenase-2 promoter-dependent transcriptional activities by sesamol. PMID: 25759517 Ref: NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. PMID: 26116564 |
Ref: NADPH Oxidase 1 Activity and ROS Generation Are Regulated by Grb2/Cbl-Mediated Proteasomal Degradation of NoxO1 in Colon Cancer Cells. PMID: 26781991 Ref: c-Myb regulates NOX1/p38 to control survival of colorectal carcinoma cells. PMID: 27107996 Ref: beta-eudesmol, a sesquiterpene from Teucrium ramosissimum, inhibits superoxide production, proliferation, adhesion and migration of human tumor cell. PMID: 27497729 Ref: Effect of appendicectomy on colonic inflammation and neoplasia in experimental ulcerative colitis. PMID: 27500367 Ref: Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway. PMID: 27874952 |
Ref: Peptide screen identifies a new NADPH oxidase inhibitor: impact on cell migration and invasion. PMID: 27743884 Ref: Redox signaling in the gastrointestinal tract. PMID: 28062361 Ref: Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells. PMID: 28498822 Ref: Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway. PMID: 29262595 |
Ref: Identification and Characterization of a Novel NADPH Oxidase 1 (Nox1) Inhibitor That Suppresses Proliferation of Colon and Stomach Cancer Cells. PMID: 29269607 Ref: Expression of NOX Family Genes and Their Clinical Significance in Colorectal Cancer. PMID: 29781053 Ref: NoxO1 Controls Proliferation of Colon Epithelial Cells. PMID: 29867954 Ref: Correction: Reversion of resistance to oxaliplatin by inhibition of p38 MAPK in colorectal cancer cell lines: involvement of the calpain / Nox1 pathway. PMID: 29928496 |