Primary Site >> Pancreatic Cancer
Gene >> NOTCH1
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Ref: The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. PMID: 16327489 |
Ref: Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells. PMID: 16284950 Ref: Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells. PMID: 16510599 Ref: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. PMID: 16546962 Ref: Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. PMID: 16628653 Ref: Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer. PMID: 16885366 |
Ref: Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice. PMID: 17297654 Ref: Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. PMID: 17361329 |
Ref: Synergistic effects of multiple natural products in pancreatic cancer cells. PMID: 18640131 |
Ref: Ligand-dependent Notch signaling is involved in tumor initiation and tumor maintenance in pancreatic cancer. PMID: 19258443 Ref: TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway. PMID: 19318573 Ref: Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles. PMID: 19405120 Ref: A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics. PMID: 19580337 Ref: MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells. PMID: 19714243 |
Ref: Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. PMID: 19901970 Ref: Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. PMID: 20484026 Ref: Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. PMID: 20624967 |
Ref: DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism. PMID: 21285251 Ref: Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. PMID: 21304978 Ref: Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells. PMID: 21463919 Ref: Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation. PMID: 22074495 |
Ref: Metformin inhibits cell proliferation, migration and invasion by attenuating CSC function mediated by deregulating miRNAs in pancreatic cancer cells. PMID: 22086681 Ref: Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. PMID: 22108826 Ref: The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells. PMID: 22479394 Ref: Adamantyl Retinoid-Related Molecules Induce Apoptosis in Pancreatic Cancer Cells by Inhibiting IGF-1R and Wnt/beta-Catenin Pathways. PMID: 22570653 Ref: The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models. PMID: 22752426 Ref: The matricellular protein CCN1/Cyr61 is a critical regulator of Sonic Hedgehog in pancreatic carcinogenesis. PMID: 23027863 Ref: Genistein inhibits cell growth and induces apoptosis through up-regulation of miR-34a in pancreatic cancer cells. PMID: 23140286 Ref: Notch3 and HEY-1 as prognostic biomarkers in pancreatic adenocarcinoma. PMID: 23226563 |
Ref: Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway. PMID: 22918166 Ref: Notch 1 tumor expression is lacking in highly proliferative pancreatic neuroendocrine tumors. PMID: 23225326 Ref: Sonic advance: CCN1 regulates sonic hedgehog in pancreatic cancer. PMID: 23255052 Ref: Notch1 contributes to chemoresistance to gemcitabine and serves as an unfavorable prognostic indicator in pancreatic cancer. PMID: 23568245 Ref: Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. PMID: 23684930 Ref: DCLK1 regulates pluripotency and angiogenic factors via microRNA-dependent mechanisms in pancreatic cancer. PMID: 24040120 Ref: Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells. PMID: 24040121 Ref: [Effect of Notch1 signaling pathway activation on pancreatic cancer cell proliferation in vitro]. PMID: 24144754 Ref: Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. PMID: 24216479 Ref: NOTCH1 expression predicts patient prognosis in esophageal squamous cell cancer. PMID: 24217574 Ref: The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells. PMID: 24392017 |
Ref: Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal model. PMID: 24195616 Ref: Notch pathway activation is associated with pancreatic cancer treatment failure. PMID: 24555978 Ref: Effect of Wasabi Component 6-(Methylsulfinyl)hexyl Isothiocyanate and Derivatives on Human Pancreatic Cancer Cells. PMID: 24575144 Ref: XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism. PMID: 24880079 Ref: Berberine diminishes side population and down-regulates stem cell-associated genes in the pancreatic cancer cell lines PANC-1 and MIA PaCa-2. PMID: 24894821 Ref: Nuclear retention of Fbw7 by specific inhibitors of nuclear export leads to Notch1 degradation in pancreatic cancer. PMID: 24899509 Ref: [Down-regulation of Notch1 by small interfering RNA enhances chemosensitivity to gemcitabine in pancreatic cancer cells through activating apoptosis activity]. PMID: 24998655 |
Ref: Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer. PMID: 25344906 Ref: Anti-tumor effect of the extract from qingyihuaji formula on pancreatic cancer by down-regulating Notch-4 and Jagged-1. PMID: 25842732 Ref: Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells. PMID: 25887885 Ref: Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines. PMID: 26087898 Ref: Glycogen synthase kinase-3 inhibitor AR-A014418 suppresses pancreatic cancer cell growth via inhibition of GSK-3-mediated Notch1 expression. PMID: 26147011 Ref: Alternative splicing of NUMB, APP and VEGFA as the features of pancreatic ductal carcinoma. PMID: 26261495 |
Ref: Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. PMID: 26279302 Ref: A bright future for protein kinase D1 as a drug target to prevent or treat pancreatic cancer. PMID: 27308552 Ref: Retraction. PMID: 27534919 Ref: Cellular Prion Protein Mediates Pancreatic Cancer Cell Survival and Invasion through Association with and Enhanced Signaling of Notch1. PMID: 27639164 Ref: Numb/Notch signaling pathway modulation enhances human pancreatic cancer cell radiosensitivity. PMID: 27677287 Ref: Retraction. PMID: 27696400 Ref: Retraction. PMID: 27696401 Ref: DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer. PMID: 27755532 |
Ref: Garcinol downregulates Notch1 signaling via modulating miR-200c and suppresses oncogenic properties of PANC-1 cancer stem-like cells. PMID: 26400206 Ref: Effect of NR5A2 inhibition on pancreatic cancer stem cell (CSC) properties and epithelial-mesenchymal transition (EMT) markers. PMID: 27996162 Ref: Leptin-Notch signaling axis is involved in pancreatic cancer progression. PMID: 27999190 Ref: Comparative analysis of Notch1 and Notch2 binding sites in the genome of BxPC3 pancreatic cancer cells. PMID: 28123599 Ref: miR-34a inhibits pancreatic cancer progression through Snail1-mediated epithelial-mesenchymal transition and the Notch signaling pathway. PMID: 28145431 Ref: Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFbeta and JNK/AP-1. PMID: 28981109 |
Ref: Peptide-targeted, stimuli-responsive polymersomes for delivering a cancer stemness inhibitor to cancer stem cell microtumors. PMID: 29304437 Ref: Notch signaling molecule is involved in the invasion of MiaPaCa2 cells induced by CoCl2 via regulating epithelialmesenchymal transition. PMID: 29393429 Ref: The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling. PMID: 29414775 Ref: Retraction notice to "Notch-1 induces Epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells". PMID: 29606293 Ref: Expression of Notch receptors and their ligands in pancreatic ductal adenocarcinoma. PMID: 29896227 Ref: A systematic analysis of the association between Notch1 expression and the patients with digestive tract cancers. PMID: 30043645 Ref: Retraction: Down-regulation of Notch-1 Inhibits Invasion by Inactivation of Nuclear Factor-kappaB, Vascular Endothelial Growth Factor, and Matrix Metalloproteinase-9 in Pancreatic Cancer Cells. PMID: 30217886 Ref: Norepinephrine enhances cell viability and invasion, and inhibits apoptosis of pancreatic cancer cells in a Notch1dependent manner. PMID: 30226612 Ref: Retraction: Downregulation of Notch-1 Contributes to Cell Growth Inhibition and Apoptosis in Pancreatic Cancer Cells. PMID: 30275273 |