Primary Site >> Colorectal Cancer
Gene >> NOTCH1
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Ref: The FBXW7 beta-form is suppressed in human glioma cells. PMID: 17274947 |
Ref: The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the Delta1/Notch1 pathway. PMID: 18320325 Ref: Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. PMID: 18950493 Ref: Activation of Notch signaling in human colon adenocarcinoma. PMID: 19020755 |
Ref: Notch1 expression in colorectal carcinoma determines tumor differentiation status. PMID: 18777195 Ref: KLF4 gene expression is inhibited by the notch signaling pathway that controls goblet cell differentiation in mouse gastrointestinal tract. PMID: 19109406 Ref: gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. PMID: 19147571 Ref: Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. PMID: 19325125 |
Ref: Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling. PMID: 19935714 Ref: Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis. PMID: 20053782 Ref: High level of Notch1 protein is associated with poor overall survival in colorectal cancer. PMID: 20058190 Ref: Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer. PMID: 20068187 Ref: Distinct expression profiles of Notch-1 protein in human solid tumors: Implications for development of targeted therapeutic monoclonal antibodies. PMID: 20631820 Ref: F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor. PMID: 20638938 Ref: Notch1 regulates the growth of human colon cancers. PMID: 20665495 |
Ref: Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo. PMID: 20839263 Ref: MicroRNA expression profile of colon cancer stem-like cells in HT29 adenocarcinoma cell line. PMID: 21130073 Ref: Hypoxia and lineage specification of cell line-derived colorectal cancer stem cells. PMID: 21368208 Ref: SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. PMID: 21368833 Ref: Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. PMID: 21378202 Ref: Notch3 signalling promotes tumour growth in colorectal cancer. PMID: 21598247 Ref: Notch1 and Notch2 have opposite prognostic effects on patients with colorectal cancer. PMID: 21709139 Ref: Notch1 regulates the effects of matrix metalloproteinase-9 on colitis-associated cancer in mice. PMID: 21723221 Ref: Notch1 expression, which is related to p65 Status, is an independent predictor of prognosis in colorectal cancer. PMID: 21771876 Ref: STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH(+)/CD133(+) stem cell-like human colon cancer cells. PMID: 22074823 |
Ref: Expression and clinical significance of Notch signaling genes in colorectal cancer. PMID: 22219033 Ref: A phase II study of RO4929097 in metastatic colorectal cancer. PMID: 22445247 Ref: ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a gamma-secretase inhibitor and irinotecan in colorectal cancer. PMID: 22521243 Ref: Notch1 counteracts WNT/beta-catenin signaling through chromatin modification in colorectal cancer. PMID: 22863622 Ref: Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF. PMID: 22992310 Ref: Epigenetic silencing of Notch signaling in gastrointestinal cancers. PMID: 23085543 |
Ref: Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. PMID: 23525843 Ref: Knockdown of TRB3 induces apoptosis in human lung adenocarcinoma cells through regulation of Notch 1 expression. PMID: 23632994 Ref: Colon cancer mesenchymal stem cells modulate the tumorigenicity of colon cancer through interleukin 6. PMID: 23751564 Ref: Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. PMID: 24141420 Ref: Disparity expression of Notch1 in benign and malignant colorectal diseases. PMID: 24312514 |
Ref: Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines. PMID: 23676439 Ref: NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells. PMID: 24525742 Ref: Nuclear Notch3 expression is associated with tumor recurrence in patients with stage II and III colorectal cancer. PMID: 24728738 Ref: Correlation of over-expressions of miR-21 and Notch-1 in human colorectal cancer with clinical stages. PMID: 24780321 Ref: Human colorectal CD24+ cancer stem cells are susceptible to epithelial-mesenchymal transition. PMID: 24858473 Ref: microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer. PMID: 24885920 Ref: The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer. PMID: 24960159 Ref: Colocalization of beta-catenin with Notch intracellular domain in colon cancer: a possible role of Notch1 signaling in activation of CyclinD1-mediated cell proliferation. PMID: 25073953 Ref: MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1. PMID: 25149074 Ref: [Effect of siRNA-mediated silencing of Notch2 on proliferation of the HepG2 human hepatocellular carcinoma cells]. PMID: 25180870 Ref: Synergistic association of Notch and NFkappaB signaling and role of Notch signaling in modulating epithelial to mesenchymal transition in colorectal adenocarcinoma. PMID: 25257945 Ref: Tripartite interactions between Wnt signaling, Notch and Myb for stem/progenitor cell functions during intestinal tumorigenesis. PMID: 25290188 Ref: Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut. PMID: 25295490 Ref: Expression of Notch-signaling pathway in familial adenomatous polyposis and its clinical significance. PMID: 25487926 |
Ref: Target-enriched next-generation sequencing reveals differences between primary and secondary ovarian tumors in formalin-fixed, paraffin-embedded tissue. PMID: 25545608 Ref: Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. PMID: 25671302 Ref: Folates Induce Colorectal Carcinoma HT29 Cell Line Proliferation Through Notch1 Signaling. PMID: 25802929 Ref: Notch-1 promotes stemness and epithelial to mesenchymal transition in colorectal cancer. PMID: 25914224 Ref: Sasa quelpaertensis Leaf Extract Inhibits Colon Cancer by Regulating Cancer Cell Stemness in Vitro and in Vivo. PMID: 25941936 Ref: A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors. PMID: 26046801 Ref: Angiogenesis-related protein expression in bevacizumab-treated metastatic colorectal cancer: NOTCH1 detrimental to overall survival. PMID: 26394830 Ref: Immunohistochemical expression of Notch1, Jagged1, NF-kappaB and MMP-9 in colorectal cancer patients and the relationship to clinicopathological parameters. PMID: 26406415 Ref: Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway. PMID: 26650241 |
Ref: A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer. PMID: 26152787 Ref: Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells. PMID: 26419617 Ref: Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway. PMID: 26530025 Ref: A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. PMID: 26744411 Ref: Paradoxical E-cadherin increase in 5FU-resistant colon cancer is unaffected during mesenchymal-epithelial reversion induced by gamma-secretase inhibition. PMID: 26746659 Ref: Deciphering the anti-angiogenic effect of endostatin/cyclophosphamide to normalize tumor micrangium through notch signaling pathway in colon cancer. PMID: 26762567 Ref: Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases. PMID: 26797410 Ref: Inflammation increases NOTCH1 activity via MMP9 and is counteracted by Eicosapentaenoic Acid-free fatty acid in colon cancer cells. PMID: 26864323 Ref: Exome sequencing in one family with gastric- and rectal cancer. PMID: 26872740 Ref: Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer. PMID: 26930714 Ref: Reconstitution of TGFBR2 in HCT116 colorectal cancer cells causes increased LFNG expression and enhanced N-acetyl-d-glucosamine incorporation into Notch1. PMID: 27156840 Ref: miR-139-5p sensitizes colorectal cancer cells to 5-fluorouracil by targeting NOTCH-1. PMID: 27173050 Ref: Copy number changes of clinically actionable genes in melanoma, non-small cell lung cancer and colorectal cancer-A survey across 822 routine diagnostic cases. PMID: 27218826 Ref: Walnut Phenolic Extract and Its Bioactive Compounds Suppress Colon Cancer Cell Growth by Regulating Colon Cancer Stemness. PMID: 27455311 Ref: Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family. PMID: 27460529 Ref: Targeted molecular profiling of rare genetic alterations in colorectal cancer using next-generation sequencing. PMID: 27568332 Ref: DNA copy number alterations, gene expression changes and disease-free survival in patients with colorectal cancer: a 10 year follow-up. PMID: 27709558 Ref: MiR-139-5p reverses CD44+/CD133+-associated multidrug resistance by downregulating NOTCH1 in colorectal carcinoma cells. PMID: 27738333 Ref: Compositional analysis of walnut lipid extracts and properties as an anti-cancer stem cell regulator via suppression of the self-renewal capacity. PMID: 30263315 |
Ref: Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis. PMID: 27861153 Ref: Overexpression of PER3 Inhibits Self-Renewal Capability and Chemoresistance of Colorectal Cancer Stem-Like Cells via Inhibition of Notch and beta-Catenin Signaling. PMID: 27983919 Ref: PDGF-D promotes cell growth, aggressiveness, angiogenesis and EMT transformation of colorectal cancer by activation of Notch1/Twist1 pathway. PMID: 28035069 Ref: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. PMID: 28148261 Ref: Metformin depresses overactivated Notch1/Hes1 signaling in colorectal cancer patients with type 2 diabetes mellitus. PMID: 28177944 Ref: High-Throughput Genomic Profiling of Adult Solid Tumors Reveals Novel Insights into Cancer Pathogenesis. PMID: 28235761 Ref: FAM83D knockdown regulates proliferation, migration and invasion of colorectal cancer through inhibiting FBXW7/Notch-1 signalling pathway. PMID: 28407575 Ref: A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer). PMID: 28460341 Ref: Effects of RUNX3 mediated Notch signaling pathway on biological characteristics of colorectal cancer cells. PMID: 28498402 Ref: Chloroform fraction of Scutellaria barbata D. Don inhibits the growth of colorectal cancer cells by activating miR34a. PMID: 28498458 Ref: Killing effects of Huaier Granule combined with DC-CIK on nude mice transplanted with colon carcinoma cell line. PMID: 28537906 Ref: KLF2 inhibits cell growth via regulating HIF-1alpha/Notch-1 signal pathway in human colorectal cancer HCT116 cells. PMID: 28628187 Ref: Kaiso differentially regulates components of the Notch signaling pathway in intestinal cells. PMID: 28637464 Ref: Spica Prunellae extract suppresses the growth of human colon carcinoma cells by targeting multiple oncogenes via activating miR-34a. PMID: 28713966 Ref: Portulaca oleracea extract can inhibit nodule formation of colon cancer stem cells by regulating gene expression of the Notch signal transduction pathway. PMID: 28714363 Ref: MicroRNA-34a suppresses colorectal cancer metastasis by regulating Notch signaling. PMID: 28781671 Ref: STRAP Promotes Stemness of Human Colorectal Cancer via Epigenetic Regulation of the NOTCH Pathway. PMID: 28827371 Ref: Tumor Heterogeneity Predicts Metastatic Potential in Colorectal Cancer. PMID: 28939741 Ref: NOTCH1 activates the Wnt/beta-catenin signaling pathway in colon cancer. PMID: 28947978 Ref: The expression profile and clinicopathological significance of Notch1 in patients with colorectal cancer: a meta-analysis. PMID: 28984154 Ref: Long non-coding RNA LINC00152 promotes cell proliferation, metastasis, and confers 5-FU resistance in colorectal cancer by inhibiting miR-139-5p. PMID: 29180678 Ref: Genistein induces apoptosis of colon cancer cells by reversal of epithelial-to-mesenchymal via a Notch1/NF-kappaB/slug/E-cadherin pathway. PMID: 29202800 |
Ref: Notch signaling pathway dampens tumor-infiltrating CD8(+) T cells activity in patients with colorectal carcinoma. PMID: 29096354 Ref: Inhibition of Notch1/Hes1 signaling pathway improves radiosensitivity of colorectal cancer cells. PMID: 29126793 Ref: Antitumor activity of Notch1 inhibition in human colorectal carcinoma cells. PMID: 29286145 Ref: Appendiceal goblet cell carcinoids and adenocarcinomas ex-goblet cell carcinoid are genetically distinct from primary colorectal-type adenocarcinoma of the appendix. PMID: 29327707 Ref: Platelet-derived growth factor-D promotes colorectal cancer cell migration, invasion and proliferation by regulating Notch1 and matrix metalloproteinase-9. PMID: 29434852 Ref: lncRNA FAM83H-AS1 is associated with the prognosis of colorectal carcinoma and promotes cell proliferation by targeting the Notch signaling pathway. PMID: 29434883 Ref: Kynurenine promotes the goblet cell differentiation of HT-29 colon carcinoma cells by modulating Wnt, Notch and AhR signals. PMID: 29436668 Ref: Long non-coding RNA CCAL promotes papillary thyroid cancer progression by activation of NOTCH1 pathway. PMID: 29471887 Ref: MicroRNA-744 inhibits cellular proliferation and invasion of colorectal cancer by directly targeting oncogene Notch1. PMID: 29471890 Ref: miR-34a increases the sensitivity of colorectal cancer cells to 5-fluorouracil in vitro and in vivo. PMID: 29511598 Ref: [Killing effect of Huaier combined with DC-CIK on nude mice bearing colon cancer HT29 stem cells in vivo]. PMID: 29552828 Ref: Significance of Notch and Wnt signaling for chemoresistance of colorectal cancer cells HCT116. PMID: 29637602 Ref: Population-based statistical inference for temporal sequence of somatic mutations in cancer genomes. PMID: 29697365 Ref: Integrated molecular subtyping defines a curable oligometastatic state in colorectal liver metastasis. PMID: 29728604 Ref: Hypoxia-induced upregulation of Orai1 drives colon cancer invasiveness and angiogenesis. PMID: 29753044 Ref: Interrogation of transcriptomic changes associated with drug-induced hepatic sinusoidal dilatation in colorectal cancer. PMID: 29879147 Ref: Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. PMID: 29899427 Ref: Modification of alpha2,6-sialylation mediates the invasiveness and tumorigenicity of non-small cell lung cancer cells in vitro and in vivo via Notch1/Hes1/MMPs pathway. PMID: 29981167 Ref: MicroRNA449a is a potential predictor of colitisassociated colorectal cancer progression. PMID: 30015944 Ref: Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer. PMID: 30038258 Ref: A systematic analysis of the association between Notch1 expression and the patients with digestive tract cancers. PMID: 30043645 Ref: Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells. PMID: 30065304 Ref: The Prognostic Value of Cancer Stem Cell Markers (Notch1, ALDH1, and CD44) in Primary Colorectal Carcinoma. PMID: 30136202 Ref: Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells. PMID: 30154153 Ref: POFUT1 promotes colorectal cancer development through the activation of Notch1 signaling. PMID: 30250219 Ref: Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma. PMID: 30323897 Ref: Quantitative analysis of somatically-acquired and constitutive uniparental disomy in gastrointestinal cancers. PMID: 30350313 Ref: POFUT1 as a Promising Novel Biomarker of Colorectal Cancer. PMID: 30380753 |