Primary Site >> Biliary tract Cancer

Gene >> NOTCH1

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Ref: Inducible nitric oxide synthase up-regulates Notch-1 in mouse cholangiocytes: implications for carcinogenesis.
PMID: 15887117
 Ref: Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma.
PMID: 20149523
Ref: Opposing actions of endocannabinoids on cholangiocarcinoma growth is via the differential activation of Notch signaling.
PMID: 20347808
 Ref: Expression and clinicopathological significance of notch signaling and cell-fate genes in biliary tract cancer.
PMID: 21931375
 Ref: On the role of notch1 and adult hepatocytes in murine intrahepatic cholangiocarcinoma development.
PMID: 23526421
Ref: The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma.
PMID: 23688168
 Ref: Notch1 is overexpressed in human intrahepatic cholangiocarcinoma and is associated with its proliferation, invasiveness and sensitivity to 5-fluorouracil in vitro.
PMID: 24700253
Ref: Clinicopathological significance of aberrant Notch receptors in intrahepatic cholangiocarcinoma.
PMID: 25031748
 Ref: LTbetaR signalling preferentially accelerates oncogenic AKT-initiated liver tumours.
PMID: 26206664
Ref: The Expression of Notch 1 and Notch 3 in Gallbladder Cancer and Their Clinicopathological Significance.
PMID: 26634853
Ref: Oncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice.
PMID: 26877611
Ref: Anti-Tumor Effects of Second Generation beta-Hydroxylase Inhibitors on Cholangiocarcinoma Development and Progression.
PMID: 26954680
Ref: Notch3 drives development and progression of cholangiocarcinoma.
PMID: 27791012
Ref: Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties.
PMID: 27821106
 Ref: Epigenetic Silencing of miRNA-34a in Human Cholangiocarcinoma via EZH2 and DNA Methylation: Impact on Regulation of Notch Pathway.
PMID: 28923203
 Ref: Effect of midkine on gemcitabine resistance in biliary tract cancer.
PMID: 29344648
Ref: Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model.
PMID: 29348467
Ref: Notch2 controls hepatocyte-derived cholangiocarcinoma formation in mice.
PMID: 29545603
Ref: Regulation of periostin expression by Notch signaling in hepatocytes and liver cancer cell lines.
PMID: 30384995